BS8054

antibody from Bioworld Technology, Inc

Targeting: IL1RL1 DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS8054

Provider

Bioworld Technology, Inc

Product name

IL1RL1 polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human IL1RL1.

Description

The orphan receptor ST2/T1 is a member of the IL-1R family, although it does not bind IL-1Ï«, IL-1ÉÇ or IL-1R antagonist, and it is preferentially expressed on the surface of T helper cell type 2 (Th2) cells, but not Th1 cells. The gene encoding human ST2 maps to chromosome 2q12.1 and its transcription is controlled by two distinct promoters, an upstream promoter, which directs transcription in hematopoietic cells, and a downstream promoter, which directs transcription in fibroblasts. ST2 is also alternatively spliced to produce three variants: the secreted soluble form (ST2), which is expressed in fibroblasts; the membrane-bound form (ST2L), which is expressed in hematopoietic cells; and ST2V, which is localized on the plasma membrane and is expressed in the stomach, small intestine and colon. ST2 has immunoregulatory properties and, therefore, may have therapeutic potential as an anti-inflammatory agent.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.