Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [1]
- Flow cytometry [1]
- Blocking/Neutralizing [1]
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Validation data
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- Product number
- AF523 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal ST2/IL-33R Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human ST2/IL-33 R in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with recombinant mouse ST2/IL-33 R is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis.
Interleukin 1 Receptor-Like 1 (IL1RL1) Promotes Airway Bacterial and Viral Infection and Inflammation.
IL-33 down-regulates CLDN1 expression through the ERK/STAT3 pathway in keratinocytes.
IL-33 stimulates CXCL8/IL-8 secretion in goblet cells but not normally differentiated airway cells.
Detection of soluble ST2 in human follicular fluid and luteinized granulosa cells.
ST2 and IL-33 in pregnancy and pre-eclampsia.
Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis.
Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts.
A novel IL-1 family cytokine, IL-33, potently activates human eosinophils.
Gene induction during differentiation of human pulmonary type II cells in vitro.
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines.
Zhou Q, Wu X, Wang X, Yu Z, Pan T, Li Z, Chang X, Jin Z, Li J, Zhu Z, Liu B, Su L
Oncogene 2020 Feb;39(7):1414-1428
Oncogene 2020 Feb;39(7):1414-1428
Interleukin 1 Receptor-Like 1 (IL1RL1) Promotes Airway Bacterial and Viral Infection and Inflammation.
Schaunaman N, Sanchez A, Dimasuay KG, Pavelka N, Numata M, Alam R, Martin RJ, Chu HW
Infection and immunity 2019 Jul;87(7)
Infection and immunity 2019 Jul;87(7)
IL-33 down-regulates CLDN1 expression through the ERK/STAT3 pathway in keratinocytes.
Ryu WI, Lee H, Bae HC, Jeon J, Ryu HJ, Kim J, Kim JH, Son JW, Kim J, Imai Y, Yamanishi K, Jeong SH, Son SW
Journal of dermatological science 2018 Jun;90(3):313-322
Journal of dermatological science 2018 Jun;90(3):313-322
IL-33 stimulates CXCL8/IL-8 secretion in goblet cells but not normally differentiated airway cells.
Tanabe T, Shimokawaji T, Kanoh S, Rubin BK
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2014 Apr;44(4):540-52
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2014 Apr;44(4):540-52
Detection of soluble ST2 in human follicular fluid and luteinized granulosa cells.
Southcombe JH, Lédée N, Perrier d'Hauterive S, Turner K, Child T, Snider JV, Redman CW, Sargent IL, Granne I
PloS one 2013;8(9):e74385
PloS one 2013;8(9):e74385
ST2 and IL-33 in pregnancy and pre-eclampsia.
Granne I, Southcombe JH, Snider JV, Tannetta DS, Child T, Redman CW, Sargent IL
PloS one 2011;6(9):e24463
PloS one 2011;6(9):e24463
Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis.
Hong YS, Moon SJ, Joo YB, Jeon CH, Cho ML, Ju JH, Oh HJ, Heo YJ, Park SH, Kim HY, Min JK
Journal of Korean medical science 2011 Sep;26(9):1132-9
Journal of Korean medical science 2011 Sep;26(9):1132-9
Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts.
Nishida A, Andoh A, Imaeda H, Inatomi O, Shiomi H, Fujiyama Y
Gut 2010 Apr;59(4):531-41
Gut 2010 Apr;59(4):531-41
A novel IL-1 family cytokine, IL-33, potently activates human eosinophils.
Cherry WB, Yoon J, Bartemes KR, Iijima K, Kita H
The Journal of allergy and clinical immunology 2008 Jun;121(6):1484-90
The Journal of allergy and clinical immunology 2008 Jun;121(6):1484-90
Gene induction during differentiation of human pulmonary type II cells in vitro.
Wade KC, Guttentag SH, Gonzales LW, Maschhoff KL, Gonzales J, Kolla V, Singhal S, Ballard PL
American journal of respiratory cell and molecular biology 2006 Jun;34(6):727-37
American journal of respiratory cell and molecular biology 2006 Jun;34(6):727-37
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines.
Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA
Immunity 2005 Nov;23(5):479-90
Immunity 2005 Nov;23(5):479-90
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Human ST2/IL-33 R by Western Blot. Detection of Human ST2/IL-33 R by Western Blot.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Human ST2/IL-33 R by Simple WesternTM. Detection of Human ST2/IL-33 R by Simple WesternTM.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- ST2/IL-33 R in Human Liver. ST2/IL-33 R in Human Liver.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of ST2/IL-33 R in KG-1a Human Cell Line by Flow Cytometry. Detection of ST2/IL-33 R in KG-1a Human Cell Line by Flow Cytometry.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- IFN-? Secretion Induced by IL-33 and Neutralization by Human ST2/IL-33 R Antibody. IFN-? Secretion Induced by IL-33 and Neutralization by Human ST2/IL-33 R Antibody.