AGTO-G042E

antibody from Creative Biolabs
Targeting: IL18R1 CD218a, IL-1Rrp, IL1RRP
Provider product page for AGTO-G042E
No application information provided.

Antibody data

Product number
AGTO-G042E - Provider product page
Provider
Creative Biolabs
Product name
IL-18-PE immunotoxin
Antibody type
Monoclonal
Description
This immunotoxin was achieved by conjugating/fusing the IL-18 to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to IL-18R¨Cbearing antigen-presenting cells (APCs). Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating Experimental autoimmune encephalomyelitis (EAE).
Reactivity
Mouse
Host
Mouse
IL18R1 protein structure - AGTO-G042E shown in red.