Antibody data
- Antibody Data
- Antigen structure
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- Product number
- AGTO-G042E - Provider product page
- Provider
- Creative Biolabs
- Product name
- IL-18-PE immunotoxin
- Antibody type
- Monoclonal
- Description
- This immunotoxin was achieved by conjugating/fusing the IL-18 to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to IL-18R¨Cbearing antigen-presenting cells (APCs). Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating Experimental autoimmune encephalomyelitis (EAE).
- Reactivity
- Mouse
- Host
- Mouse
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