313806

antibody from BioLegend

Targeting: IL18R1 CD218a, IL-1Rrp, IL1RRP

Immunohistochemistry (Recommended by provider)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

313806

Provider

BioLegend

Proper citation

BioLegend Cat#313806, RRID:AB_2123649

Product name

Biotin anti-human CD218a (IL-18R‡)

Antibody type

Monoclonal

Antigen

Human NK cell line NK0 constitutively expressing IL-18 receptors

Description

IL-18 receptor is composed of an α and a β subunit that combine to form a high affinity receptor for IL-18. IL-18 receptor α chain, also known as CDw218a, is a 75-80 kD type I transmembrane protein. It is expressed on NK cells, neutrophils, endothelial cells, and subsets of T and B cells. The expression of CDw218a on lymphocytes is upregulated after activation. The interaction of IL-18 and IL-18 receptor has been reported to be implicated in promotion of Th1 cytokine production and atherogenesis. The H44 antibody is specific for IL-18 receptor α chain and has been reported to block IL-18 binding to the receptor and to be useful for the identification of IL-18 receptor by flow cytometry and IHC.

Reactivity

Human

Host

Mouse

Conjugate

Biotin

Isotype

IgG

Vial size

100 µg

Concentration

0.5 mg/ml