MAB840

antibody from R&D Systems

Targeting: IL18R1 CD218a, IL-1Rrp, IL1RRP

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Blocking/Neutralizing (Recommended by provider)

Antibody Data

Product number

MAB840

Provider

R&D Systems

Product name

Anti-Human IL-18 R alpha/IL-1 R5 Monoclonal Antibody (Clone 70625)

Antibody type

Monoclonal

Antigen

Mouse myeloma cell line NS0-derived recombinant human IL‑18 Rα/IL-1 R5, Glu20-Arg329

Description

Protein A or G purified from hybridoma culture supernatant

Reactivity

Human

Host

Mouse

Antigen sequence

Q13478


Isotype

IgG

Vial size

500 µg

References

Submitted references

Interleukin-37 expression and its potential role in oral leukoplakia and oral squamous cell carcinoma.

Lin L, Wang J, Liu D, Liu S, Xu H, Ji N, Zhou M, Zeng X, Zhang D, Li J, Chen Q
Scientific reports 2016 May 26;6:26757

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Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter.

Wang J, Sun C, Gerdes N, Liu C, Liao M, Liu J, Shi MA, He A, Zhou Y, Sukhova GK, Chen H, Cheng XW, Kuzuya M, Murohara T, Zhang J, Cheng X, Jiang M, Shull GE, Rogers S, Yang CL, Ke Q, Jelen S, Bindels R, Ellison DH, Jarolim P, Libby P, Shi GP
Nature medicine 2015 Jul;21(7):820-6

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Regulation of development of CD56 bright CD11c + NK-like cells with helper function by IL-18.

Li W, Okuda A, Yamamoto H, Yamanishi K, Terada N, Yamanishi H, Tanaka Y, Okamura H
PloS one 2013;8(12):e82586

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IL-1 family members IL-18 and IL-33 upregulate the inflammatory potential of differentiated human Th1 and Th2 cultures.

Blom L, Poulsen LK
Journal of immunology (Baltimore, Md. : 1950) 2012 Nov 1;189(9):4331-7

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Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis.

Takei S, Hoshino T, Matsunaga K, Sakazaki Y, Sawada M, Oda H, Takenaka S, Imaoka H, Kinoshita T, Honda S, Ida H, Fukuda TA, Aizawa H
Arthritis research & therapy 2011 Mar 24;13(2):R52

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Glomerular accumulation of plasmacytoid dendritic cells in active lupus nephritis: role of interleukin-18.

Tucci M, Quatraro C, Lombardi L, Pellegrino C, Dammacco F, Silvestris F
Arthritis and rheumatism 2008 Jan;58(1):251-62

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IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response.

Rao DA, Tracey KJ, Pober JS
Journal of immunology (Baltimore, Md. : 1950) 2007 Nov 15;179(10):6536-46

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IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response.

Rao DA, Tracey KJ, Pober JS
Journal of immunology (Baltimore, Md. : 1950) 2007 Nov 15;179(10):6536-46

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CD molecules 2006--human cell differentiation molecules.

Zola H, Swart B, Banham A, Barry S, Beare A, Bensussan A, Boumsell L, D Buckley C, Bühring HJ, Clark G, Engel P, Fox D, Jin BQ, Macardle PJ, Malavasi F, Mason D, Stockinger H, Yang X
Journal of immunological methods 2007 Jan 30;319(1-2):1-5

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Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription.

Ebert EC, Mehta V
Cellular immunology 2006 May;241(1):7-13