Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- MAB2088 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal Langerin/CD207 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human Langerin/CD207 in direct ELISAs and Western blots.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells.
HIV-1 replication in Langerhans and interstitial dendritic cells is inhibited by neutralizing and Fc-mediated inhibitory antibodies.
Generation of mature human myelomonocytic cells through expansion and differentiation of pluripotent stem cell-derived lin-CD34+CD43+CD45+ progenitors.
Hutter C, Kauer M, Simonitsch-Klupp I, Jug G, Schwentner R, Leitner J, Bock P, Steinberger P, Bauer W, Carlesso N, Minkov M, Gadner H, Stingl G, Kovar H, Kriehuber E
Blood 2012 Dec 20;120(26):5199-208
Blood 2012 Dec 20;120(26):5199-208
HIV-1 replication in Langerhans and interstitial dendritic cells is inhibited by neutralizing and Fc-mediated inhibitory antibodies.
Peressin M, Holl V, Schmidt S, Decoville T, Mirisky D, Lederle A, Delaporte M, Xu K, Aubertin AM, Moog C
Journal of virology 2011 Jan;85(2):1077-85
Journal of virology 2011 Jan;85(2):1077-85
Generation of mature human myelomonocytic cells through expansion and differentiation of pluripotent stem cell-derived lin-CD34+CD43+CD45+ progenitors.
Choi KD, Vodyanik MA, Slukvin II
The Journal of clinical investigation 2009 Sep;119(9):2818-29
The Journal of clinical investigation 2009 Sep;119(9):2818-29
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Supportive validation
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Langerin/CD207 in Human Immature Dentritic Cells by Flow Cytometry. Human immature dentritic cells differentated from human peripheral blood mononuclear cell derived CD14+ cells were treated with 20 ng/mL Recombinant Human IL-4 (Catalog # 204-IL) and 50 ng/mL Recombinant Human GM-CSF (Catalog # 215-GM) for 6-7 days and then stained with Mouse Anti-Human Langerin/CD207 Monoclonal Antibody (Catalog # MAB2088, filled histogram) or isotype control (Catalog # MAB002, open histogram), followed by Goat F(ab)2 Anti-Mouse IgG (H+L) Allophycocyanin (Catalog # F0101B). View our protocol for Staining Membrane-associated Proteins.