ABIN786758

antibody from antibodies-online

Targeting: CD207 CLEC4K, Langerin

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

ABIN786758

Provider

antibodies-online

Product name

anti-CD207 Molecule, Langerin (CD207) antibody

Antibody type

Monoclonal

Antigen

Other

Description

Purified

Reactivity

Human, Mouse, Rat

Host

Rat

Isotype

IgG

Antibody clone number

929F3-01

Vial size

50 μg

References

Submitted references

The late endosomal adaptor molecule p14 (LAMTOR2) regulates TGFβ1-mediated homeostasis of Langerhans cells.

Sparber F, Tripp CH, Komenda K, Scheffler JM, Clausen BE, Huber LA, Romani N, Stoitzner P
The Journal of investigative dermatology 2015 Jan;135(1):119-29

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Anatomical distribution analysis reveals lack of Langerin+ dermal dendritic cells in footpads and tail of C57BL/6 mice.

Voisin B, Mairhofer DG, Chen S, Stoitzner P, Mueller CG, Flacher V
Experimental dermatology 2014 May;23(5):354-6

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Second-generation Langerhans cells originating from epidermal precursors are essential for CD8+ T cell priming.

Elnekave M, Furmanov K, Shaul Y, Capucha T, Eli-Berchoer L, Zelentsova K, Clausen BE, Hovav AH
Journal of immunology (Baltimore, Md. : 1950) 2014 Feb 15;192(4):1395-403

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Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-tolerance.

Flacher V, Tripp CH, Mairhofer DG, Steinman RM, Stoitzner P, Idoyaga J, Romani N
EMBO molecular medicine 2014 Aug 1;6(9):1191-204

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Quiescent innate response to infective filariae by human Langerhans cells suggests a strategy of immune evasion.

Boyd A, Bennuru S, Wang Y, Sanprasert V, Law M, Chaussabel D, Nutman TB, Semnani RT
Infection and immunity 2013 May;81(5):1420-9

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Comparative histology and immunohistochemistry of porcine versus human skin.

Debeer S, Le Luduec JB, Kaiserlian D, Laurent P, Nicolas JF, Dubois B, Kanitakis J
European journal of dermatology : EJD 2013 Jul-Aug;23(4):456-66

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Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function.

Kellersch B, Brocker T
Blood 2013 Jan 10;121(2):298-307

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Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo.

Luckashenak N, Wähe A, Breit K, Brakebusch C, Brocker T
Journal of immunology (Baltimore, Md. : 1950) 2013 Jan 1;190(1):27-35

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Langerin negative dendritic cells promote potent CD8+ T-cell priming by skin delivery of live adenovirus vaccine microneedle arrays.

Bachy V, Hervouet C, Becker PD, Chorro L, Carlin LM, Herath S, Papagatsias T, Barbaroux JB, Oh SJ, Benlahrech A, Athanasopoulos T, Dickson G, Patterson S, Kwon SY, Geissmann F, Klavinskis LS
Proceedings of the National Academy of Sciences of the United States of America 2013 Feb 19;110(8):3041-6

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Human papillomavirus type 8 interferes with a novel C/EBPβ-mediated mechanism of keratinocyte CCL20 chemokine expression and Langerhans cell migration.

Sperling T, Ołdak M, Walch-Rückheim B, Wickenhauser C, Doorbar J, Pfister H, Malejczyk M, Majewski S, Keates AC, Smola S
PLoS pathogens 2012;8(7):e1002833

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Human Langerhans cells control Th cells via programmed death-ligand 1 in response to bacterial stimuli and nickel-induced contact allergy.

Hitzler M, Majdic O, Heine G, Worm M, Ebert G, Luch A, Peiser M
PloS one 2012;7(10):e46776

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Aging affects epidermal Langerhans cell development and function and alters their miRNA gene expression profile.

Xu YP, Qi RQ, Chen W, Shi Y, Cui ZZ, Gao XH, Chen HD, Zhou L, Mi QS
Aging 2012 Nov;4(11):742-54

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Age-related changes in expression and function of Toll-like receptors in human skin.

Iram N, Mildner M, Prior M, Petzelbauer P, Fiala C, Hacker S, Schöppl A, Tschachler E, Elbe-Bürger A
Development (Cambridge, England) 2012 Nov;139(22):4210-9

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Langerhans cells require MyD88-dependent signals for Candida albicans response but not for contact hypersensitivity or migration.

Haley K, Igyártó BZ, Ortner D, Bobr A, Kashem S, Schenten D, Kaplan DH
Journal of immunology (Baltimore, Md. : 1950) 2012 May 1;188(9):4334-9

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Langerhans cells down-regulate inflammation-driven alveolar bone loss.

Arizon M, Nudel I, Segev H, Mizraji G, Elnekave M, Furmanov K, Eli-Berchoer L, Clausen BE, Shapira L, Wilensky A, Hovav AH
Proceedings of the National Academy of Sciences of the United States of America 2012 May 1;109(18):7043-8

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Skin langerin+ dendritic cells transport intradermally injected anti-DEC-205 antibodies but are not essential for subsequent cytotoxic CD8+ T cell responses.

Flacher V, Tripp CH, Haid B, Kissenpfennig A, Malissen B, Stoitzner P, Idoyaga J, Romani N
Journal of immunology (Baltimore, Md. : 1950) 2012 Mar 1;188(5):2146-55

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CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization.

Langlet C, Tamoutounour S, Henri S, Luche H, Ardouin L, Grégoire C, Malissen B, Guilliams M
Journal of immunology (Baltimore, Md. : 1950) 2012 Feb 15;188(4):1751-60

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Characterization of resident and migratory dendritic cells in human lymph nodes.

Segura E, Valladeau-Guilemond J, Donnadieu MH, Sastre-Garau X, Soumelis V, Amigorena S
The Journal of experimental medicine 2012 Apr 9;209(4):653-60

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Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization.

Edelson BT, Bradstreet TR, KC W, Hildner K, Herzog JW, Sim J, Russell JH, Murphy TL, Unanue ER, Murphy KM
PloS one 2011;6(10):e25660

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Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets.

Kastenmüller K, Wille-Reece U, Lindsay RW, Trager LR, Darrah PA, Flynn BJ, Becker MR, Udey MC, Clausen BE, Igyarto BZ, Kaplan DH, Kastenmüller W, Germain RN, Seder RA
The Journal of clinical investigation 2011 May;121(5):1782-96

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Phenotypic localization of distinct DC subsets in mouse Peyer Patch.

Rochereau N, Verrier B, Pin JJ, Genin C, Paul S
Vaccine 2011 May 9;29(20):3655-61

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Calcitonin gene-related peptide is an important regulator of cutaneous immunity: effect on dendritic cell and T cell functions.

Mikami N, Matsushita H, Kato T, Kawasaki R, Sawazaki T, Kishimoto T, Ogitani Y, Watanabe K, Miyagi Y, Sueda K, Fukada S, Yamamoto H, Tsujikawa K
Journal of immunology (Baltimore, Md. : 1950) 2011 Jun 15;186(12):6886-93

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Characterization of dendritic cells subpopulations in skin and afferent lymph in the swine model.

Marquet F, Bonneau M, Pascale F, Urien C, Kang C, Schwartz-Cornil I, Bertho N
PloS one 2011 Jan 27;6(1):e16320

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Langerin+ dermal dendritic cells are critical for CD8+ T cell activation and IgH γ-1 class switching in response to gene gun vaccines.

Stoecklinger A, Eticha TD, Mesdaghi M, Kissenpfennig A, Malissen B, Thalhamer J, Hammerl P
Journal of immunology (Baltimore, Md. : 1950) 2011 Feb 1;186(3):1377-83

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The earliest intrathymic precursors of CD8α(+) thymic dendritic cells correspond to myeloid-type double-negative 1c cells.

Luche H, Ardouin L, Teo P, See P, Henri S, Merad M, Ginhoux F, Malissen B
European journal of immunology 2011 Aug;41(8):2165-75

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Acute ablation of Langerhans cells enhances skin immune responses.

Bobr A, Olvera-Gomez I, Igyarto BZ, Haley KM, Hogquist KA, Kaplan DH
Journal of immunology (Baltimore, Md. : 1950) 2010 Oct 15;185(8):4724-8

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Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells.

Poulin LF, Salio M, Griessinger E, Anjos-Afonso F, Craciun L, Chen JL, Keller AM, Joffre O, Zelenay S, Nye E, Le Moine A, Faure F, Donckier V, Sancho D, Cerundolo V, Bonnet D, Reis e Sousa C
The Journal of experimental medicine 2010 Jun 7;207(6):1261-71

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CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells.

Henri S, Poulin LF, Tamoutounour S, Ardouin L, Guilliams M, de Bovis B, Devilard E, Viret C, Azukizawa H, Kissenpfennig A, Malissen B
The Journal of experimental medicine 2010 Jan 18;207(1):189-206

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Functional redundancy of Langerhans cells and Langerin+ dermal dendritic cells in contact hypersensitivity.

Noordegraaf M, Flacher V, Stoitzner P, Clausen BE
The Journal of investigative dermatology 2010 Dec;130(12):2752-9

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Herpes simplex virus type 2 enhances HIV-1 susceptibility by affecting Langerhans cell function.

de Jong MA, de Witte L, Taylor ME, Geijtenbeek TB
Journal of immunology (Baltimore, Md. : 1950) 2010 Aug 1;185(3):1633-41

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Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network.

Chorro L, Sarde A, Li M, Woollard KJ, Chambon P, Malissen B, Kissenpfennig A, Barbaroux JB, Groves R, Geissmann F
The Journal of experimental medicine 2009 Dec 21;206(13):3089-100

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Langerhans cells in porcine skin.

Nfon CK, Dawson H, Toka FN, Golde WT
Veterinary immunology and immunopathology 2008 Dec 15;126(3-4):236-47

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Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes.

Abadie V, Badell E, Douillard P, Ensergueix D, Leenen PJ, Tanguy M, Fiette L, Saeland S, Gicquel B, Winter N
Blood 2005 Sep 1;106(5):1843-50

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Mouse lymphoid tissue contains distinct subsets of langerin/CD207 dendritic cells, only one of which represents epidermal-derived Langerhans cells.

Douillard P, Stoitzner P, Tripp CH, Clair-Moninot V, Aït-Yahia S, McLellan AD, Eggert A, Romani N, Saeland S
The Journal of investigative dermatology 2005 Nov;125(5):983-94

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Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function.

Kissenpfennig A, Aït-Yahia S, Clair-Moninot V, Stössel H, Badell E, Bordat Y, Pooley JL, Lang T, Prina E, Coste I, Gresser O, Renno T, Winter N, Milon G, Shortman K, Romani N, Lebecque S, Malissen B, Saeland S, Douillard P
Molecular and cellular biology 2005 Jan;25(1):88-99

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Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity.

Kaplan DH, Jenison MC, Saeland S, Shlomchik WD, Shlomchik MJ
Immunity 2005 Dec;23(6):611-20

Immunocytochemistry

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

Image(s): Immunofluorescence

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

Image(s): Immunofluorescence

Immunohistochemistry

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

Image(s): Immunohistochemistry

Flow cytometry

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

Image(s): Flow cytometry