Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 352203 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#352203, RRID:AB_10900993
- Product name
- PE anti-human CD207 (Langerin)
- Antibody type
- Monoclonal
- Antigen
- Primary human Langerhans cells
- Description
- CD207, also known as Langerin, is a 40 kD type II transmemberane cell glycoprotein which belongs to C-type lectin with mannose binding specificity. It is predominantly expressed on Langerhans cells and induces the formation of Birbeck granules, the Langerhans cell hallmark organelle. It is also found on several other subtypes of dendritic cells, such as dermal CD103-positive dendritic cells and splenic CD8-positive dendritic cells. Langerin is generally thought to be involved in antigen processing. Recently, it has been found that HIV captured by Langerin was internalized into Birbeck granule and degraded, which results in inhibition of HIV-1 infection and subsequent transmission.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Yellow dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Monocyte-derived Langerhans cells were stimulated with recombinant human GM-CSF, TGF-β and IL-4 for 3 days, followed by an additional 3-day culture with rhGM-CSF and TGF-β. They were then stained with CD1a APC and CD207 (clone 10E2) PE (top) or mouse IgG1, κ PE isotype control (bottom).
- Conjugate
- Yellow dye