Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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Validation data
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- Product number
- AF2088 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Langerin/CD207 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects human Langerin/CD207 in direct ELISAs and Western blots.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
Q9UJ71
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Chemokine Levels in the Penile Coronal Sulcus Correlate with HIV-1 Acquisition and Are Reduced by Male Circumcision in Rakai, Uganda.
Plasmacytoid dendritic cells infiltrate the skin in positive tuberculin skin test indurations.
In situ distribution of HIV-binding CCR5 and C-type lectin receptors in the human endocervical mucosa.
HIV-1 replication in Langerhans and interstitial dendritic cells is inhibited by neutralizing and Fc-mediated inhibitory antibodies.
Prodger JL, Gray RH, Shannon B, Shahabi K, Kong X, Grabowski K, Kigozi G, Nalugoda F, Serwadda D, Wawer MJ, Reynolds SJ, Liu CM, Tobian AA, Kaul R
PLoS pathogens 2016 Nov;12(11):e1006025
PLoS pathogens 2016 Nov;12(11):e1006025
Plasmacytoid dendritic cells infiltrate the skin in positive tuberculin skin test indurations.
Bond E, Liang F, Sandgren KJ, Smed-Sörensen A, Bergman P, Brighenti S, Adams WC, Betemariam SA, Rangaka MX, Lange C, Wilkinson RJ, Andersson J, Loré K
The Journal of investigative dermatology 2012 Jan;132(1):114-23
The Journal of investigative dermatology 2012 Jan;132(1):114-23
In situ distribution of HIV-binding CCR5 and C-type lectin receptors in the human endocervical mucosa.
Hirbod T, Kaldensjö T, Broliden K
PloS one 2011;6(9):e25551
PloS one 2011;6(9):e25551
HIV-1 replication in Langerhans and interstitial dendritic cells is inhibited by neutralizing and Fc-mediated inhibitory antibodies.
Peressin M, Holl V, Schmidt S, Decoville T, Mirisky D, Lederle A, Delaporte M, Xu K, Aubertin AM, Moog C
Journal of virology 2011 Jan;85(2):1077-85
Journal of virology 2011 Jan;85(2):1077-85
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Langerin/CD207 in Human Skin. Langerin/CD207 was detected in immersion fixed paraffin-embedded sections of human skin using 15 µg/mL Goat Anti-Human Langerin/CD207 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2088) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of Langerhans cells in the skin epidermis. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.