26951-1-AP

antibody from Proteintech Group

Targeting: PLIN5 LSDA5, LSDP5, MLDP, OXPAT

Provider product page for 26951-1-AP

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [38]
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Product number: 26951-1-AP - Provider product page
Provider: Proteintech Group
Product name: Perilipin 5 antibody
Antibody type: Polyclonal
Description: KD/KO validated Perilipin 5 antibody (Cat. #26951-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, pig, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Porcine
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PLIN5 protein structure - 26951-1-AP shown in red.

Submitted references Chronic intermittent hypoxia increases Parkinson's disease susceptibility via PPARα-mediated lipid droplet-mitochondrial dysfunction.

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Unraveling the potential mechanisms of Xiaochaihu decoction alleviates metabolic associated fatty liver disease (MAFLD) by integrated transcriptomics, metabolomics, and network pharmacology.

Zhong Y, Zhu XM, Li JC, Sheng LS, Qi JY, Shen XH, Du H, Huang NN, Sun R
Chinese medicine 2026 Jan 20;21(1):41

Hydroxytyrosol Prevents Metabolic-Associated Steatohepatitis by Inhibiting SOCS2-Mediated Ferroptosis in High-Fat Diet Mice.

Yi D, Wu Z, Li X, Shao B, Xiao Y, Li T, Zhang X, Zhu J, Yang T, Deng Y, Huang T, Qiu T, Bai J, Shi X, Wu C, Wu Z, Sun X, Wang N
Journal of agricultural and food chemistry 2026 Feb 25;74(7):6265-6277

Gut microbiota dysbiosis contributes to diabetic nephropathy via affecting renal lipid deposition and inflammatory responses.

Liu P, Hu P, Jin M, Wan Y, Wu J, Sun W, Tang Y, Huang L, Zhang D, Shi D, Xie T, Tong Y, Zheng H, Wang L, He H, Xu X
Journal of translational medicine 2026 Feb 23;24(1)

Novel assessment of postprandial metabolism reveals sex-specific metabolic flexibility and lipid remodeling following volumetric muscle loss.

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American journal of physiology. Regulatory, integrative and comparative physiology 2026 Feb 1;330(2):R243-R260

Jiangtang Tiaozhi formula ameliorates MASLD by regulating liver ABCD2/PEX2/ATGL axis-mediated fatty acid metabolic reprogramming.

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Metformin promotes lipid droplet-mitochondria coupling and improves insulin secretion in pancreatic β-cells exposed to lipotoxicity.

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Berberine partially ameliorates cardiolipotoxicity in diabetic cardiomyopathy by modulating SIRT3-mediated lipophagy to remodel lipid droplets homeostasis.

Chen W, Jin T, Xie Y, Zhong C, Gao H, Zhang L, Ju J, Cheng T, Li M, Wang H, Yang Z, Deng Q, Du Z, Liang H
British journal of pharmacology 2025 Oct;182(20):5038-5056

Accumulation of lipids after acute direct and indirect traumatic injuries in male and female mice.

Bruzina AS, Crum BA, Raymond-Pope CJ, Call JA, Greising SM
BMC musculoskeletal disorders 2025 Oct 8;26(1):932

Cardiac lipid droplets differ under pathological and physiological conditions.

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Journal of lipid research 2025 Nov;66(11):100920

Exercise attenuates hepatic ectopic lipid deposition in high fat-diet rats via PKA-mediated phosphorylation of Perilipin5.

Dong S, Yang Y, Li W, Wang L, Li T
Scientific reports 2025 Nov 27;15(1):42466

RNF180 suppressed aggressiveness by degrading NOTCH1, TRIM24 and FOXC1, and chemoresistance by degrading ACC1 and ACLY in colorectal cancer.

Li N, Zhang R, Zhao XX, Zhou L, Li YL, Cui ZG, Zheng HC
International immunopharmacology 2025 Nov 14;165:115445

Dietary combination of sucrose and linoleic acid increases intramyocellular lipid and impairs muscle strength in female Zucker diabetic fatty rats.

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Copper-Induced DRP1 Activation Disrupts Mitochondrial-Lipid Droplet Contact to Promote Hepatic Steatosis.

Li Q, Su L, Guo P, Liao J, Tang Z
Journal of agricultural and food chemistry 2025 May 28;73(21):13006-13020

Sesamol Ameliorates Lipid Deposition by Maintaining the Integrity of the Lipid Droplet-Mitochondria Connection in Diabetic Nephropathy.

Yang M, Liu C, Jiang N, Liu Y, Luo S, Li C, Zhao H, Han Y, Li L, Xiao L, Chen W, Sun L
Journal of agricultural and food chemistry 2025 Jan 22;73(3):2124-2137

O-GlcNAc transferase plays dual antiviral roles by integrating innate immunity and lipid metabolism.

Dong H, Liang C, Zhang J, Wu W, Kumar N, Liu Z, Sun Y, Liao Z, Cheng X, Yu Y, Zhang Y, Holtzman MJ, Li J, Gowdy KM, Thomas PG, Badjic JD, Ma A, Ma Q, Yount JS, Liu SL, Wen H
Nature communications 2025 Aug 19;16(1):7721

Lipid Droplets Metabolism Mediated by ANXA7-PPARγ Signaling Axis Regulates Spinal Cord Injury Repair in Mice.

Chen L, Liu H, Jiang L, Wang Z, Chang Y, Li N, Feng S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2417326

NR4A1-mediated regulation of lipid droplets in progesterone synthesis in goat luteal cells†.

Yu H, Li X, Zhao J, Wang W, Wei Q, Mao D
Biology of reproduction 2024 Sep 14;111(3):640-654

Activation of NOD1 on tumor-associated macrophages augments CD8(+) T cell-mediated antitumor immunity in hepatocellular carcinoma.

Zhang F, Jiang Q, Cai J, Meng F, Tang W, Liu Z, Lin X, Liu W, Zhou Y, Shen X, Xue R, Dong L, Zhang S
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Spatial Transcriptomic Study Reveals Heterogeneous Metabolic Adaptation and a Role of Pericentral PPARα/CAR/Ces2a Axis During Fasting in Mouse Liver.

Wang S, Xu B, Liang J, Feng Y, Han P, Shen J, Li X, Zheng M, Zhang T, Zhang C, Mi P, Zhang Y, Liu Z, Li S, Yuan D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2405240

Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease.

Du J, Ji X, Xu B, Du Q, Li Y, Zhou B, Liu X, Xu Z, Jiang Y, Kou B, Li Z, Cui C, Lin J
Metabolism: clinical and experimental 2024 Mar;152:155769

Mitofusin-2 induced by exercise modifies lipid droplet-mitochondria communication, promoting fatty acid oxidation in male mice with NAFLD.

Bórquez JC, Díaz-Castro F, La Fuente FP, Espinoza K, Figueroa AM, Martínez-Ruíz I, Hernández V, López-Soldado I, Ventura R, Domingo JC, Bosch M, Fajardo A, Sebastián D, Espinosa A, Pol A, Zorzano A, Cortés V, Hernández-Alvarez MI, Troncoso R
Metabolism: clinical and experimental 2024 Mar;152:155765

Spatially resolved rewiring of mitochondria-lipid droplet interactions in hepatic lipid homeostasis.

Kang SWS, Brown LA, Miller CB, Barrows KM, Golino JL, Cultraro CM, Feliciano D, Cornelius-Muwanuzi MB, Tran AD, Kruhlak M, Lobanov A, Cam M, Porat-Shliom N
bioRxiv : the preprint server for biology 2024 Dec 12;

Increased FGF-21 Improves Ectopic Lipid Deposition in the Liver and Skeletal Muscle.

Jia Y, Yu H, Liang J, Zhang Q, Sun J, Yang H, Yan H, Zhang S, Li Y, Jin Y, Yang M
Nutrients 2024 Apr 23;16(9)

Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.

Wang Z, Yang T, Zeng M, Wang Z, Chen Q, Chen J, Christian M, He Z
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Perilipin5 protects against non-alcoholic steatohepatitis by increasing 11-Dodecenoic acid and inhibiting the occurrence of ferroptosis.

Xu X, Qiu J, Li X, Chen J, Li Y, Huang X, Zang S, Ma X, Liu J
Nutrition & metabolism 2023 Jun 22;20(1):29

Daytime-restricted feeding enhances running endurance without prior exercise in mice.

Xin H, Huang R, Zhou M, Chen J, Zhang J, Zhou T, Ji S, Liu X, Tian H, Lam SM, Bao X, Li L, Tong S, Deng F, Shui G, Zhang Z, Wong CCL, Li MD
Nature metabolism 2023 Jul;5(7):1236-1251

Rab8a as a mitochondrial receptor for lipid droplets in skeletal muscle.

Ouyang Q, Chen Q, Ke S, Ding L, Yang X, Rong P, Feng W, Cao Y, Wang Q, Li M, Su S, Wei W, Liu M, Liu J, Zhang X, Li JZ, Wang HY, Chen S
Developmental cell 2023 Feb 27;58(4):289-305.e6

Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility.

Cinato M, Mardani I, Miljanovic A, Drevinge C, Laudette M, Bollano E, Henricsson M, Tolö J, Bauza Thorbrügge M, Levin M, Lindbom M, Arif M, Pacher P, Andersson L, Olofsson CS, Borén J, Levin MC
Life science alliance 2023 Apr;6(4)

Canagliflozin Attenuates Hepatic Steatosis and Atherosclerosis Progression in Western Diet-Fed ApoE-Knockout Mice.

Zuo Q, Zhang G, He L, Ma S, Ma H, Zhai J, Wang Z, Zhang T, Wang Y, Guo Y
Drug design, development and therapy 2022;16:4161-4177

Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3β-Nrf2 pathway.

Huo K, Ma KG, Guo QY, Duan P, Xu J
International immunopharmacology 2022 Jul;108:108718

Knockdown of hepatocyte Perilipin-3 mitigates hepatic steatosis and steatohepatitis caused by hepatocyte CGI-58 deletion in mice.

Bao X, Ma X, Huang R, Chen J, Xin H, Zhou M, Li L, Tong S, Zhang Q, Shui G, Deng F, Yu L, Li MD, Zhang Z
Journal of molecular cell biology 2022 Dec 26;14(8)

miR-183 and miR-96 orchestrate both glucose and fat utilization in skeletal muscle.

Wang H, Ma M, Li Y, Liu J, Sun C, Liu S, Ma Y, Yan Y, Tang Z, Shen S, Yu J, Wu Y, Jiang J, Wang L, Jin ZB, Ying H, Li Y
EMBO reports 2021 Sep 6;22(9):e52247

Aryl hydrocarbon receptor promotes lipid droplet biogenesis and metabolic shift in respiratory Club cells.

Wang HC, Liu KY, Wang LT, Hsu SH, Wang SC, Huang SK
Human cell 2021 May;34(3):785-799

Effects of Simvastatin on Lipid Metabolism in Wild-Type Mice and Mice with Muscle PGC-1α Overexpression.

Panajatovic MV, Singh F, Krähenbühl S, Bouitbir J
International journal of molecular sciences 2021 May 7;22(9)

Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation.

Feng J, Xie L, Yu X, Liu C, Dong H, Lu W, Kong R
Biochemical and biophysical research communications 2021 Mar 12;544:22-30

Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells.

Tan Y, Jin Y, Wang Q, Huang J, Wu X, Ren Z
Cells 2019 Oct 11;8(10)

ER stress mediated degradation of diacylglycerol acyltransferase impairs mitochondrial functions in TMCO1 deficient cells.

Wang X, Wang QC, Sun Z, Li T, Yang K, An C, Guo C, Tang TS
Biochemical and biophysical research communications 2019 May 14;512(4):914-920

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