CABT-B8412

antibody from Creative Diagnostics

Targeting: CENPB

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

CABT-B8412

Provider

Creative Diagnostics

Product name

Anti-CENPB monoclonal antibody, clone 3E-8

Antibody type

Monoclonal

Description

This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3.00E-08

Vial size

200 _g

Concentration

200 Ã×g/ml

Storage

Store at 4°C, DO NOT FREEZE. Stable for one year from the date of shipment.