Antibody data

Product number
BS3069 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GnTÏ«4 (H65) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 32-82 of Human GnTÏ«4.
Description
Alpha 1,4-N-acetylflucosaminyltransferase (Ï«4Gn-T) mediates the biosynthesis of mucin type glycoprotein (O-glycan). Ï«4Gn-T acts as the key enzyme for the formation of the unique glycan GlcNAcÏ«1-4GalÉÇ1-R, and most efficiently transfers N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. Ï«4Gn-T is a single-pass type II membrane protein associated with the Golgi apparatus and contains the conserved DXD motif involved in catalytic activity. It is expressed in stomach and pancreas, as well as in gastric cancer cells. Ï«4Gn-T is not expressed in peripheral blood cells, making it a useful biomarker for pancreatic cancer. Ï«4Gn-T and Mucin 6 expression is upregulated in the gastric mucosa of H. pylori infected patients, which suggest the involvement of Ï«4Gn-T in defense against H. pylori infection.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
A4GNT protein structure - BS3069 shown in red.