Antibody data
- Antibody Data
- Antigen structure
- References [43]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 13578-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13578-1-AP, RRID:AB_2220174
- Product name
- ABCG1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ABCG1 antibody (Cat. #13578-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Neutrophil-like pH-responsive pro-efferocytic nanoparticles improve neurological recovery by promoting erythrophagocytosis after intracerebral hemorrhage.
Decreased expression of ATP-binding cassette protein G1 promotes abnormal adipogenesis of condylar chondrocytes in temporomandibular joint osteoarthritis.
Flagellar hook protein FlgE promotes macrophage activation and atherosclerosis by targeting ATP5B.
MaiJiTong granule attenuates atherosclerosis by reducing ferroptosis via activating STAT6-mediated inhibition of DMT1 and SOCS1/p53 pathways in LDLR(-/-) mice.
Inhibition of Toll-like Receptors Alters Macrophage Cholesterol Efflux and Foam Cell Formation.
Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring.
PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer.
Up-regulation of ABCG1 is associated with methotrexate resistance in acute lymphoblastic leukemia cells.
Diterpenoids inhibit ox-LDL-induced foam cell formation in RAW264.7 cells by promoting ABCA1 mediated cholesterol efflux.
Cyclic fasting bolsters cholesterol biosynthesis inhibitors' anticancer activity.
Astaxanthin Alleviates Foam Cell Formation and Promotes Cholesterol Efflux in Ox-LDL-Induced RAW264.7 Cells via CircTPP2/miR-3073b-5p/ABCA1 Pathway.
Shenlian extract protected ox-LDL-loaded macrophages against ER stress by promoting LAL-LXRα mediated cholesterol flux.
SIAH1 ubiquitination-modified HMGCR inhibits lung cancer progression and promotes drug sensitivity through cholesterol synthesis.
Qihuang Zhuyu Formula Attenuates Atherosclerosis via Targeting PPARγ to Regulate Cholesterol Efflux and Endothelial Cell Inflammation.
Cyclodextrin boostered-high density lipoprotein for antiatherosclerosis by regulating cholesterol efflux and efferocytosis.
Exercise Ameliorates Atherosclerosis via Up-Regulating Serum β-Hydroxybutyrate Levels.
Artemisinin and Procyanidins loaded multifunctional nanocomplexes alleviate atherosclerosis via simultaneously modulating lipid influx and cholesterol efflux.
Opuntia dillenii Haw. Polysaccharide Promotes Cholesterol Efflux in THP-1-Derived Foam Cells via the PPARγ-LXRα Signaling Pathway.
Characterization of an Aging-Based Diagnostic Gene Signature and Molecular Subtypes With Diverse Immune Infiltrations in Atherosclerosis.
Inositol hexaphosphate sensitizes hepatocellular carcinoma to oxaliplatin relating inhibition of CCN2-LRP6-β-catenin-ABCG1 signaling pathway.
Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages.
Expression of the circular RNAs in astaxanthin promotes cholesterol efflux from THP-1 cells based on RNA-seq.
Targeting macrophage liver X receptors by hydrogel-encapsulated T0901317 reduces atherosclerosis without effect on hepatic lipogenesis.
ABCG1 Attenuates Oxidative Stress Induced by H(2)O(2) through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells.
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
Structures and anti-atherosclerotic effects of 1,6-α-glucans from Fructus Corni.
The circFASN/miR-33a pathway participates in tacrolimus-induced dysregulation of hepatic triglyceride homeostasis.
Regulation mechanism of silkworm pupa oil PUFAs on cholesterol metabolism in hepatic cell L-02.
Oxaliplatin resistance is enhanced by saracatinib via upregulation Wnt-ABCG1 signaling in hepatocellular carcinoma.
Food with calorie restriction reduces the development of atherosclerosis in apoE-deficient mice.
Thioredoxin-1 promotes macrophage reverse cholesterol transport and protects liver from steatosis.
Low-dose PCB126 compromises circadian rhythms associated with disordered glucose and lipid metabolism in mice.
Metformin ameliorates Ox-LDL-induced foam cell formation in raw264.7 cells by promoting ABCG-1 mediated cholesterol efflux.
ALDH2 deficiency inhibits Ox-LDL induced foam cell formation via suppressing CD36 expression.
Early Presymptomatic Changes in the Proteome of Mitochondria-Associated Membrane in the APP/PS1 Mouse Model of Alzheimer's Disease.
Functional interplay between liver X receptor and AMP-activated protein kinase α inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy.
25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism.
MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition.
Effects of Porphyromonas gingivalis lipopolysaccharide on the expression of key genes involved in cholesterol metabolism in macrophages.
Mitochondrion-Targeted Peptide SS-31 Inhibited Oxidized Low-Density Lipoproteins-Induced Foam Cell Formation through both ROS Scavenging and Inhibition of Cholesterol Influx in RAW264.7 Cells.
ABCG1 deficiency promotes endothelial apoptosis by endoplasmic reticulum stress-dependent pathway.
DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.
ATP-binding cassette transporter G1 protects against endothelial dysfunction induced by high glucose.
Fan L, Jin L, Tang T, Zheng Y, Chen Z, Lin H, Ding C, Wang T, Chen H, Guo Y, Xu C, Zhou H, Wu X, Fu X, Yan F, Mao Z, Chen G
Theranostics 2024;14(1):283-303
Theranostics 2024;14(1):283-303
Decreased expression of ATP-binding cassette protein G1 promotes abnormal adipogenesis of condylar chondrocytes in temporomandibular joint osteoarthritis.
Kang X, Liu Q, Shi Y, Wang H, Zhang H, Ye T, Zhang J, He F, Zhang M
Journal of oral rehabilitation 2024 May;51(5):805-816
Journal of oral rehabilitation 2024 May;51(5):805-816
Flagellar hook protein FlgE promotes macrophage activation and atherosclerosis by targeting ATP5B.
Li Y, Zhang M, Li Y, Shen Y, Wang X, Li X, Wang Y, Yu T, Lv J, Qin Y
Atherosclerosis 2024 Mar;390:117429
Atherosclerosis 2024 Mar;390:117429
MaiJiTong granule attenuates atherosclerosis by reducing ferroptosis via activating STAT6-mediated inhibition of DMT1 and SOCS1/p53 pathways in LDLR(-/-) mice.
Shi J, Yang MM, Yang S, Fan F, Zheng G, Miao Y, Hua Y, Zhang J, Cheng Y, Liu S, Guo Y, Guo L, Yang X, Fan G, Ma C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155489
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155489
Inhibition of Toll-like Receptors Alters Macrophage Cholesterol Efflux and Foam Cell Formation.
Kim J, Kim JY, Byeon HE, Kim JW, Kim HA, Suh CH, Choi S, Linton MF, Jung JY
International journal of molecular sciences 2024 Jun 20;25(12)
International journal of molecular sciences 2024 Jun 20;25(12)
Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring.
Li J, Zhang S, Sun Y, Li J, Feng Z, Li H, Zhang M, Yan T, Han J, Duan Y
EMBO reports 2024 Apr;25(4):2097-2117
EMBO reports 2024 Apr;25(4):2097-2117
PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer.
Yamamoto T, Hayashida T, Masugi Y, Oshikawa K, Hayakawa N, Itoh M, Nishime C, Suzuki M, Nagayama A, Kawai Y, Hishiki T, Matsuura T, Naito Y, Kubo A, Yamamoto A, Yoshioka Y, Kurahori T, Nagasaka M, Takizawa M, Takano N, Kawakami K, Sakamoto M, Wakui M, Yamamoto T, Kitagawa Y, Kabe Y, Horisawa K, Suzuki A, Matsumoto M, Suematsu M
Cancer research 2024 Apr 1;84(7):1065-1083
Cancer research 2024 Apr 1;84(7):1065-1083
Up-regulation of ABCG1 is associated with methotrexate resistance in acute lymphoblastic leukemia cells.
Chen Y, Fang H, Sun H, Wu X, Xu Y, Zhou BS, Li H
Frontiers in pharmacology 2023;14:1331687
Frontiers in pharmacology 2023;14:1331687
Diterpenoids inhibit ox-LDL-induced foam cell formation in RAW264.7 cells by promoting ABCA1 mediated cholesterol efflux.
Zhang C, Wu X, Shi P, Ma H, Fang F, Feng Q, Zhao S, Zhang R, Huang J, Xu X, Xiao W, Cao G, Ji X
Frontiers in pharmacology 2023;14:1066758
Frontiers in pharmacology 2023;14:1066758
Cyclic fasting bolsters cholesterol biosynthesis inhibitors' anticancer activity.
Khalifa A, Guijarro A, Ravera S, Bertola N, Adorni MP, Papotti B, Raffaghello L, Benelli R, Becherini P, Namatalla A, Verzola D, Reverberi D, Monacelli F, Cea M, Pisciotta L, Bernini F, Caffa I, Nencioni A
Nature communications 2023 Oct 31;14(1):6951
Nature communications 2023 Oct 31;14(1):6951
Astaxanthin Alleviates Foam Cell Formation and Promotes Cholesterol Efflux in Ox-LDL-Induced RAW264.7 Cells via CircTPP2/miR-3073b-5p/ABCA1 Pathway.
Zhang Z, Qiu Y, Li W, Tang A, Huang H, Yao W, Li H, Zou T
Molecules (Basel, Switzerland) 2023 Feb 10;28(4)
Molecules (Basel, Switzerland) 2023 Feb 10;28(4)
Shenlian extract protected ox-LDL-loaded macrophages against ER stress by promoting LAL-LXRα mediated cholesterol flux.
Nie CX, Du XK, Yang LN, Li MJ, Liu L, Chen Y, Yang Q, Weng XG, Cai WY, Dong Y, Zhu XX, Li Q
Journal of ethnopharmacology 2023 Dec 5;317:116721
Journal of ethnopharmacology 2023 Dec 5;317:116721
SIAH1 ubiquitination-modified HMGCR inhibits lung cancer progression and promotes drug sensitivity through cholesterol synthesis.
Yuan H, Wu H, Cheng J, Xiong J
Cancer cell international 2023 Apr 16;23(1):71
Cancer cell international 2023 Apr 16;23(1):71
Qihuang Zhuyu Formula Attenuates Atherosclerosis via Targeting PPARγ to Regulate Cholesterol Efflux and Endothelial Cell Inflammation.
Wang M, Xiang Q, Sun W, Zhang H, Shi R, Guo J, Tong H, Fan M, Ding Y, Shi H, Yu P, Shen L, Wang Q, Chen X
Oxidative medicine and cellular longevity 2022;2022:2226168
Oxidative medicine and cellular longevity 2022;2022:2226168
Cyclodextrin boostered-high density lipoprotein for antiatherosclerosis by regulating cholesterol efflux and efferocytosis.
Wang Y, Gao H, Huang X, Chen Z, Kang P, Zhou Y, Qin D, Zhang W, Liu J
Carbohydrate polymers 2022 Sep 15;292:119632
Carbohydrate polymers 2022 Sep 15;292:119632
Exercise Ameliorates Atherosclerosis via Up-Regulating Serum β-Hydroxybutyrate Levels.
Xu Z, Zhang M, Li X, Wang Y, Du R
International journal of molecular sciences 2022 Mar 30;23(7)
International journal of molecular sciences 2022 Mar 30;23(7)
Artemisinin and Procyanidins loaded multifunctional nanocomplexes alleviate atherosclerosis via simultaneously modulating lipid influx and cholesterol efflux.
Zhou H, You P, Liu H, Fan J, Tong C, Yang A, Jiang Y, Liu B
Journal of controlled release : official journal of the Controlled Release Society 2022 Jan;341:828-843
Journal of controlled release : official journal of the Controlled Release Society 2022 Jan;341:828-843
Opuntia dillenii Haw. Polysaccharide Promotes Cholesterol Efflux in THP-1-Derived Foam Cells via the PPARγ-LXRα Signaling Pathway.
Li H, Huang Z, Zeng F
Molecules (Basel, Switzerland) 2022 Dec 7;27(24)
Molecules (Basel, Switzerland) 2022 Dec 7;27(24)
Characterization of an Aging-Based Diagnostic Gene Signature and Molecular Subtypes With Diverse Immune Infiltrations in Atherosclerosis.
Zhao L, Lv F, Zheng Y, Yan L, Cao X
Frontiers in molecular biosciences 2021;8:792540
Frontiers in molecular biosciences 2021;8:792540
Inositol hexaphosphate sensitizes hepatocellular carcinoma to oxaliplatin relating inhibition of CCN2-LRP6-β-catenin-ABCG1 signaling pathway.
Liao X, Zhang Y, Xu B, Ali A, Liu X, Jia Q
Journal of Cancer 2021;12(20):6071-6080
Journal of Cancer 2021;12(20):6071-6080
Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages.
Mota AC, Dominguez M, Weigert A, Snodgrass RG, Namgaladze D, Brüne B
Frontiers in immunology 2021;12:637778
Frontiers in immunology 2021;12:637778
Expression of the circular RNAs in astaxanthin promotes cholesterol efflux from THP-1 cells based on RNA-seq.
Liu J, Wei Y, Lin Y, Zhang P, Zhang Z, Huang H, Wu H, Zou T
Genes & nutrition 2021 Aug 28;16(1):13
Genes & nutrition 2021 Aug 28;16(1):13
Targeting macrophage liver X receptors by hydrogel-encapsulated T0901317 reduces atherosclerosis without effect on hepatic lipogenesis.
Ma C, Feng K, Yang X, Yang Z, Wang Z, Shang Y, Fan G, Liu L, Yang S, Li X, Han J, Duan Y, Chen Y
British journal of pharmacology 2021 Apr;178(7):1620-1638
British journal of pharmacology 2021 Apr;178(7):1620-1638
ABCG1 Attenuates Oxidative Stress Induced by H(2)O(2) through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells.
Xue J, Fan J, Li Y, Wu W, Yan Q, Zheng Q
Analytical cellular pathology (Amsterdam) 2020;2020:2095645
Analytical cellular pathology (Amsterdam) 2020;2020:2095645
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
Matsuda J, Takahashi A, Takabatake Y, Sakai S, Minami S, Yamamoto T, Fujimura R, Namba-Hamano T, Yonishi H, Nakamura J, Kimura T, Kaimori JY, Matsui I, Takahashi M, Nakao M, Izumi Y, Bamba T, Matsusaka T, Niimura F, Yanagita M, Yoshimori T, Isaka Y
Autophagy 2020 Oct;16(10):1889-1904
Autophagy 2020 Oct;16(10):1889-1904
Structures and anti-atherosclerotic effects of 1,6-α-glucans from Fructus Corni.
Zhang XW, Sui Y, Liu XX, Fu CY, Qiao YH, Liu WJ, Li ZZ, Li XQ, Cao W
International journal of biological macromolecules 2020 Oct 15;161:1346-1357
International journal of biological macromolecules 2020 Oct 15;161:1346-1357
The circFASN/miR-33a pathway participates in tacrolimus-induced dysregulation of hepatic triglyceride homeostasis.
Zhang C, Chen K, Wei R, Fan G, Cai X, Xu L, Cen B, Wang J, Xie H, Zheng S, Xu X
Signal transduction and targeted therapy 2020 Mar 27;5(1):23
Signal transduction and targeted therapy 2020 Mar 27;5(1):23
Regulation mechanism of silkworm pupa oil PUFAs on cholesterol metabolism in hepatic cell L-02.
Luo Y, Wang L, Lv Y, Wu X, Hou C, Li J
Journal of the science of food and agriculture 2020 Mar 15;100(4):1418-1425
Journal of the science of food and agriculture 2020 Mar 15;100(4):1418-1425
Oxaliplatin resistance is enhanced by saracatinib via upregulation Wnt-ABCG1 signaling in hepatocellular carcinoma.
Liao X, Song G, Xu Z, Bu Y, Chang F, Jia F, Xiao X, Ren X, Zhang M, Jia Q
BMC cancer 2020 Jan 13;20(1):31
BMC cancer 2020 Jan 13;20(1):31
Food with calorie restriction reduces the development of atherosclerosis in apoE-deficient mice.
Yang J, Zeng P, Liu L, Yu M, Su J, Yan Y, Ma J, Hu W, Yang X, Han J, Duan Y, Chen Y
Biochemical and biophysical research communications 2020 Apr 2;524(2):439-445
Biochemical and biophysical research communications 2020 Apr 2;524(2):439-445
Thioredoxin-1 promotes macrophage reverse cholesterol transport and protects liver from steatosis.
Wang X, Zhao H, Yan W, Liu Y, Yin T, Wang S, Fan M, Li C, Zhang L, Tao L
Biochemical and biophysical research communications 2019 Sep 3;516(4):1103-1109
Biochemical and biophysical research communications 2019 Sep 3;516(4):1103-1109
Low-dose PCB126 compromises circadian rhythms associated with disordered glucose and lipid metabolism in mice.
Shen X, Chen Y, Zhang J, Yan X, Liu W, Guo Y, Shan Q, Liu S
Environment international 2019 Jul;128:146-157
Environment international 2019 Jul;128:146-157
Metformin ameliorates Ox-LDL-induced foam cell formation in raw264.7 cells by promoting ABCG-1 mediated cholesterol efflux.
He X, Chen X, Wang L, Wang W, Liang Q, Yi L, Wang Y, Gao Q
Life sciences 2019 Jan 1;216:67-74
Life sciences 2019 Jan 1;216:67-74
ALDH2 deficiency inhibits Ox-LDL induced foam cell formation via suppressing CD36 expression.
Wei S, Zhang L, Bailu Wang, Zhao Y, Dong Q, Pan C, Li C, He D, Yuan Q, Xu F, Chen Y
Biochemical and biophysical research communications 2019 Apr 23;512(1):41-48
Biochemical and biophysical research communications 2019 Apr 23;512(1):41-48
Early Presymptomatic Changes in the Proteome of Mitochondria-Associated Membrane in the APP/PS1 Mouse Model of Alzheimer's Disease.
Völgyi K, Badics K, Sialana FJ, Gulyássy P, Udvari EB, Kis V, Drahos L, Lubec G, Kékesi KA, Juhász G
Molecular neurobiology 2018 Oct;55(10):7839-7857
Molecular neurobiology 2018 Oct;55(10):7839-7857
Functional interplay between liver X receptor and AMP-activated protein kinase α inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy.
Ma C, Zhang W, Yang X, Liu Y, Liu L, Feng K, Zhang X, Yang S, Sun L, Yu M, Yang J, Li X, Hu W, Miao RQ, Zhu Y, Li L, Han J, Chen Y, Duan Y
British journal of pharmacology 2018 May;175(9):1486-1503
British journal of pharmacology 2018 May;175(9):1486-1503
25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism.
Liu Y, Wei Z, Ma X, Yang X, Chen Y, Sun L, Ma C, Miao QR, Hajjar DP, Han J, Duan Y
Journal of lipid research 2018 Mar;59(3):439-451
Journal of lipid research 2018 Mar;59(3):439-451
MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition.
Zhang L, Chen Y, Yang X, Yang J, Cao X, Li X, Li L, Miao QR, Hajjar DP, Duan Y, Han J
Biochimica et biophysica acta 2016 Sep;1861(9 Pt A):1180-1191
Biochimica et biophysica acta 2016 Sep;1861(9 Pt A):1180-1191
Effects of Porphyromonas gingivalis lipopolysaccharide on the expression of key genes involved in cholesterol metabolism in macrophages.
Liu F, Wang Y, Xu J, Liu F, Hu R, Deng H
Archives of medical science : AMS 2016 Oct 1;12(5):959-967
Archives of medical science : AMS 2016 Oct 1;12(5):959-967
Mitochondrion-Targeted Peptide SS-31 Inhibited Oxidized Low-Density Lipoproteins-Induced Foam Cell Formation through both ROS Scavenging and Inhibition of Cholesterol Influx in RAW264.7 Cells.
Hao S, Ji J, Zhao H, Shang L, Wu J, Li H, Qiao T, Li K
Molecules (Basel, Switzerland) 2015 Dec 1;20(12):21287-97
Molecules (Basel, Switzerland) 2015 Dec 1;20(12):21287-97
ABCG1 deficiency promotes endothelial apoptosis by endoplasmic reticulum stress-dependent pathway.
Xue J, Wei J, Dong X, Zhu C, Li Y, Song A, Liu Z
The journal of physiological sciences : JPS 2013 Nov;63(6):435-44
The journal of physiological sciences : JPS 2013 Nov;63(6):435-44
DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.
Zhang L, Jiang M, Shui Y, Chen Y, Wang Q, Hu W, Ma X, Li X, Liu X, Cao X, Liu M, Duan Y, Han J
Biochimica et biophysica acta 2013 Jun;1831(6):1134-45
Biochimica et biophysica acta 2013 Jun;1831(6):1134-45
ATP-binding cassette transporter G1 protects against endothelial dysfunction induced by high glucose.
Xue J, Wang C, Zhu C, Li Y
Diabetes research and clinical practice 2013 Jul;101(1):72-80
Diabetes research and clinical practice 2013 Jul;101(1):72-80
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ABCG1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ABCG1. This antibody recognizes human,mouse,rat antigen. The ABCG1 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 13578-1-AP(ABCG1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 13578-1-AP(ABCG1 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue