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Western blot
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [125]
- Comments [0]
- Validations
- Western blot [5]
- Immunohistochemistry [1]
- Flow cytometry [1]
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- Product number
- NB400-132 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB400-132, RRID:AB_10125717
- Product name
- Rabbit Polyclonal ABCG1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse, Rat, Hamster, Rabbit, Simian
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1 mg/ml
- Storage
- Store at 4C. Do not freeze.
Submitted references THP-1 macrophage cholesterol efflux is impaired by palmitoleate through Akt activation.
4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters.
Hesperidin blocks varenicline-aggravated atherosclerotic plaque formation in apolipoprotein E knockout mice by downregulating net uptake of oxidized low-density lipoprotein in macrophages.
Bergaptol from blossoms of Citrus aurantium L. var. amara Engl inhibits LPS-induced inflammatory responses and ox-LDL-induced lipid deposition.
Soraphen A enhances macrophage cholesterol efflux via indirect LXR activation and ABCA1 upregulation.
Varenicline aggravates atherosclerotic plaque formation in nicotine-pretreated ApoE knockout mice due to enhanced oxLDL uptake by macrophages through downregulation of ABCA1 and ABCG1 expression.
Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis.
MicroRNA-205-5p Promotes Unstable Atherosclerotic Plaque Formation In Vivo.
24(S)-Hydroxycholesterol induces ER dysfunction-mediated unconventional cell death.
Cyclodextrin Ameliorates the Progression of Atherosclerosis via Increasing High-Density Lipoprotein Cholesterol Plasma Levels and Anti-inflammatory Effects in Rabbits.
Beta cell secretion of miR-375 to HDL is inversely associated with insulin secretion.
OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.
ABCA1 transporter reduces amphotericin B cytotoxicity in mammalian cells.
Overexpression of Salusin-α Inhibits Vascular Intimal Hyperplasia in an Atherosclerotic Rabbit Model.
Reinterpretation of the localization of the ATP binding cassette transporter ABCG1 in insulin-secreting cells and insights regarding its trafficking and function.
EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia.
SREBF1/MicroRNA-33b Axis Exhibits Potent Effect on Unstable Atherosclerotic Plaque Formation In Vivo.
A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposure.
6-Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP-1-Derived Macrophages.
Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux.
Toll-like receptor 2 downregulates the cholesterol efflux by activating the nuclear factor-κB pathway in macrophages and may be a potential therapeutic target for the prevention of atherosclerosis.
Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity.
Macrophage deficiency of miR-21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis.
ABCG1 regulates pulmonary surfactant metabolism in mice and men.
Activation of PPARγ does not contribute to macrophage ABCA1 expression and ABCA1-mediated cholesterol efflux to apoAI.
Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease.
Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages.
Quercetin stabilizes apolipoprotein E and reduces brain Aβ levels in amyloid model mice.
MicroRNA-33 Regulates the Innate Immune Response via ATP Binding Cassette Transporter-mediated Remodeling of Membrane Microdomains.
Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis.
Ursolic acid enhances macrophage autophagy and attenuates atherogenesis.
Effect of vildagliptin and pravastatin combination on cholesterol efflux in adipocytes.
Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550-Brief Report.
ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression.
Lanatoside C Promotes Foam Cell Formation and Atherosclerosis.
β Common Receptor Mediates Erythropoietin-Conferred Protection on OxLDL-Induced Lipid Accumulation and Inflammation in Macrophages.
Adipocyte ATP-binding cassette G1 promotes triglyceride storage, fat mass growth, and human obesity.
Enolase is regulated by Liver X Receptors.
Pathways of cholesterol homeostasis in mouse retina responsive to dietary and pharmacologic treatments.
RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes.
Glucagon-like peptide 1 (GLP-1)-based therapy upregulates LXR-ABCA1/ABCG1 cascade in adipocytes.
Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate.
Purple perilla extracts with α-asarone enhance cholesterol efflux from oxidized LDL-exposed macrophages.
[ABCG1 transporter gene expression in peripheral blood mononuclear cells of patients with atherosclerosis].
Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.
Fumigaclavine C activates PPARγ pathway and attenuates atherogenesis in ApoE-deficient mice.
MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo.
Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles.
Effect of apoA-I Mutations in the Capacity of Reconstituted HDL to Promote ABCG1-Mediated Cholesterol Efflux.
Inhibition of mitogen-activated protein kinase Erk1/2 promotes protein degradation of ATP binding cassette transporters A1 and G1 in CHO and HuH7 cells.
Bone marrow deficiency of MCPIP1 results in severe multi-organ inflammation but diminishes atherogenesis in hyperlipidemic mice.
The Impairment of Macrophage-to-Feces Reverse Cholesterol Transport during Inflammation Does Not Depend on Serum Amyloid A.
Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death.
Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.
Vitamin E secretion by Caco-2 monolayers to APOA1, but not to HDL, is vitamer selective.
MCP-1 impacts RCT by repressing ABCA1, ABCG1, and SR-BI through PI3K/Akt posttranslational regulation in HepG2 cells.
Characterization of palmitoylation of ATP binding cassette transporter G1: effect on protein trafficking and function.
Control of angiogenesis by AIBP-mediated cholesterol efflux.
Knock-down of the oxysterol receptor LXRα impairs cholesterol efflux in human primary macrophages: lack of compensation by LXRβ activation.
Molecular mechanisms responsible for the reduced expression of cholesterol transporters from macrophages by low-dose endotoxin.
Cholesterol efflux is differentially regulated in neurons and astrocytes: implications for brain cholesterol homeostasis.
Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice.
Overexpression of stearoyl-coenzyme A desaturase 1 in macrophages promotes reverse cholesterol transport.
Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling.
The anti-proliferative and pro-apoptotic effects of the trans9, trans11 conjugated linoleic acid isomer on MCF-7 breast cancer cells are associated with LXR activation.
Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1.
Astaxanthin enhances ATP-binding cassette transporter A1/G1 expressions and cholesterol efflux from macrophages.
Astaxanthin enhances ATP-binding cassette transporter A1/G1 expressions and cholesterol efflux from macrophages.
Human ATP-binding cassette G1 controls macrophage lipoprotein lipase bioavailability and promotes foam cell formation.
Protein kinase A modulates the activity of a major human isoform of ABCG1.
Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages.
HDL and ApoA-I inhibit antigen presentation-mediated T cell activation by disrupting lipid rafts in antigen presenting cells.
Keratinocyte ATP binding cassette transporter expression is regulated by ultraviolet light.
Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis.
Liver X receptor activation attenuates inflammatory response and protects cholinergic neurons in APP/PS1 transgenic mice.
Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI.
ABCA17 mediates sterol efflux from mouse spermatozoa plasma membranes.
Obesity and weight loss result in increased adipose tissue ABCG1 expression in db/db mice.
Phospholipase A(2)-modified low-density lipoprotein activates liver X receptor in human macrophages.
PAPP-A negatively regulates ABCA1, ABCG1 and SR-B1 expression by inhibiting LXRα through the IGF-I-mediated signaling pathway.
Overexpression of ABCG1 protein attenuates arteriosclerosis and endothelial dysfunction in atherosclerotic rabbits.
LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis.
MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-/- mice.
Involvement of cholesterol efflux pathway in the control of cardiomyocytes cholesterol homeostasis.
Effect of 6-O-α-maltosyl-β cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells.
Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages.
The effect of 17{beta}-estradiol on cholesterol content in human macrophages is influenced by the lipoprotein milieu.
Retinoic acid isomers up-regulate ATP binding cassette A1 and G1 and cholesterol efflux in rat astrocytes: implications for their therapeutic and teratogenic effects.
Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1.
Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice.
Scavenger receptor SR-BI in macrophage lipid metabolism.
Modulation of macrophage fatty acid content and composition by exposure to dyslipidemic serum in vitro.
Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity.
The structural basis for membrane binding and pore formation by lymphocyte perforin.
Coffee consumption enhances high-density lipoprotein-mediated cholesterol efflux in macrophages.
SR-BI, CD36, and caveolin-1 contribute positively to cholesterol efflux in hepatic cells.
LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner.
Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2.
Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways.
High-density lipoprotein transport through aortic endothelial cells involves scavenger receptor BI and ATP-binding cassette transporter G1.
Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice.
Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity.
Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages.
Insulin stimulates the expression of carbohydrate response element binding protein (ChREBP) by attenuating the repressive effect of Pit-1, Oct-1/Oct-2, and Unc-86 homeodomain protein octamer transcription factor-1.
Dietary soy protein isolate attenuates metabolic syndrome in rats via effects on PPAR, LXR, and SREBP signaling.
Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis.
CD36-mediated cholesterol efflux is associated with PPARgamma activation via a MAPK-dependent COX-2 pathway in macrophages.
LXR-induced reverse cholesterol transport in human airway smooth muscle is mediated exclusively by ABCA1.
Reduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitus.
A critical role for ABCG1 in macrophage inflammation and lung homeostasis.
A critical role for ABCG1 in macrophage inflammation and lung homeostasis.
ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo.
Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux.
Lipidation of apolipoprotein A-I by ATP-binding cassette transporter (ABC) A1 generates an interaction partner for ABCG1 but not for scavenger receptor BI.
ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2.
SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL.
Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1.
Genetic deletion of low density lipoprotein receptor impairs sterol-induced mouse macrophage ABCA1 expression. A new SREBP1-dependent mechanism.
Biogenesis of HDL by SAA is dependent on ABCA1 in the liver in vivo.
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.
The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein.
Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways.
PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine.
Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with Abcg1-/- bone marrow.
Transcriptional repression of ATP-binding cassette transporter A1 gene in macrophages: a novel atherosclerotic effect of angiotensin II.
Marshall JD, Courage ER, Elliott RF, Fitzpatrick MN, Kim AD, Lopez-Clavijo AF, Woolfrey BA, Ouimet M, Wakelam MJO, Brown RJ
PloS one 2020;15(5):e0233180
PloS one 2020;15(5):e0233180
4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters.
Salonurmi T, Nabil H, Ronkainen J, Hyötyläinen T, Hautajärvi H, Savolainen MJ, Tolonen A, Orešič M, Känsäkoski P, Rysä J, Hakkola J, Hukkanen J
Frontiers in pharmacology 2020;11:361
Frontiers in pharmacology 2020;11:361
Hesperidin blocks varenicline-aggravated atherosclerotic plaque formation in apolipoprotein E knockout mice by downregulating net uptake of oxidized low-density lipoprotein in macrophages.
Koga M, Kanaoka Y, Inada K, Omine S, Kataoka Y, Yamauchi A
Journal of pharmacological sciences 2020 Jun;143(2):106-111
Journal of pharmacological sciences 2020 Jun;143(2):106-111
Bergaptol from blossoms of Citrus aurantium L. var. amara Engl inhibits LPS-induced inflammatory responses and ox-LDL-induced lipid deposition.
Shen CY, Wang TX, Jiang JG, Huang CL, Zhu W
Food & function 2020 Jun 24;11(6):4915-4926
Food & function 2020 Jun 24;11(6):4915-4926
Soraphen A enhances macrophage cholesterol efflux via indirect LXR activation and ABCA1 upregulation.
Wang D, Hiebl V, Schachner D, Ladurner A, Heiss EH, Atanasov AG, Dirsch VM
Biochemical pharmacology 2020 Jul;177:114022
Biochemical pharmacology 2020 Jul;177:114022
Varenicline aggravates atherosclerotic plaque formation in nicotine-pretreated ApoE knockout mice due to enhanced oxLDL uptake by macrophages through downregulation of ABCA1 and ABCG1 expression.
Koga M, Kanaoka Y, Okamoto M, Nakao Y, Inada K, Takayama S, Kataoka Y, Yamauchi A
Journal of pharmacological sciences 2020 Jan;142(1):9-15
Journal of pharmacological sciences 2020 Jan;142(1):9-15
Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis.
Xu Y, Xu Y, Zhu Y, Sun H, Juguilon C, Li F, Fan D, Yin L, Zhang Y
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Jan 8;28(1):202-216
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Jan 8;28(1):202-216
MicroRNA-205-5p Promotes Unstable Atherosclerotic Plaque Formation In Vivo.
Meng X, Yin J, Yu X, Guo Y
Cardiovascular drugs and therapy 2020 Feb;34(1):25-39
Cardiovascular drugs and therapy 2020 Feb;34(1):25-39
24(S)-Hydroxycholesterol induces ER dysfunction-mediated unconventional cell death.
Urano Y, Ho Vo DK, Hirofumi A, Noguchi N
Cell death discovery 2019;5:113
Cell death discovery 2019;5:113
Cyclodextrin Ameliorates the Progression of Atherosclerosis via Increasing High-Density Lipoprotein Cholesterol Plasma Levels and Anti-inflammatory Effects in Rabbits.
Wang H, Zhang X, Yu B, Peng X, Liu Y, Wang A, Zhao D, Pang D, OuYang H, Tang X
Journal of cardiovascular pharmacology 2019 May;73(5):334-342
Journal of cardiovascular pharmacology 2019 May;73(5):334-342
Beta cell secretion of miR-375 to HDL is inversely associated with insulin secretion.
Sedgeman LR, Beysen C, Ramirez Solano MA, Michell DL, Sheng Q, Zhao S, Turner S, Linton MF, Vickers KC
Scientific reports 2019 Mar 7;9(1):3803
Scientific reports 2019 Mar 7;9(1):3803
OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.
Yuan C, Guo X, Zhou Q, Du F, Jiang W, Zhou X, Liu P, Chi T, Ji X, Gao J, Chen C, Lang H, Xu J, Liu D, Yang Y, Qiu S, Tang X, Chen G, Zou L
Biochimica et biophysica acta. Molecular basis of disease 2019 Jan;1865(1):161-180
Biochimica et biophysica acta. Molecular basis of disease 2019 Jan;1865(1):161-180
ABCA1 transporter reduces amphotericin B cytotoxicity in mammalian cells.
Wu A, Grela E, Wójtowicz K, Filipczak N, Hamon Y, Luchowski R, Grudziński W, Raducka-Jaszul O, Gagoś M, Szczepaniak A, Chimini G, Gruszecki WI, Trombik T
Cellular and molecular life sciences : CMLS 2019 Dec;76(24):4979-4994
Cellular and molecular life sciences : CMLS 2019 Dec;76(24):4979-4994
Overexpression of Salusin-α Inhibits Vascular Intimal Hyperplasia in an Atherosclerotic Rabbit Model.
Qian K, Feng L, Sun Y, Xiong B, Ding Y, Han P, Chen H, Chen X, Du L, Wang Y
BioMed research international 2018;2018:8973986
BioMed research international 2018;2018:8973986
Reinterpretation of the localization of the ATP binding cassette transporter ABCG1 in insulin-secreting cells and insights regarding its trafficking and function.
Harris MT, Hussain SS, Inouye CM, Castle AM, Castle JD
PloS one 2018;13(9):e0198383
PloS one 2018;13(9):e0198383
EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia.
Ying F, Cai Y, Wong HK, Chen XY, Huang IB, Vanhoutte PM, Xia Z, Xu A, Tang EHC
Biochimica et biophysica acta. Molecular and cell biology of lipids 2018 Sep;1863(9):1029-1040
Biochimica et biophysica acta. Molecular and cell biology of lipids 2018 Sep;1863(9):1029-1040
SREBF1/MicroRNA-33b Axis Exhibits Potent Effect on Unstable Atherosclerotic Plaque Formation In Vivo.
Nishino T, Horie T, Baba O, Sowa N, Hanada R, Kuwabara Y, Nakao T, Nishiga M, Nishi H, Nakashima Y, Nakazeki F, Ide Y, Koyama S, Kimura M, Nagata M, Yoshida K, Takagi Y, Nakamura T, Hasegawa K, Miyamoto S, Kimura T, Ono K
Arteriosclerosis, thrombosis, and vascular biology 2018 Oct;38(10):2460-2473
Arteriosclerosis, thrombosis, and vascular biology 2018 Oct;38(10):2460-2473
A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposure.
Sonett J, Goldklang M, Sklepkiewicz P, Gerber A, Trischler J, Zelonina T, Westerterp M, Lemaître V, Okada Y, D'Armiento J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 15;:fj201701381
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 15;:fj201701381
6-Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP-1-Derived Macrophages.
Wang D, Hiebl V, Ladurner A, Latkolik SL, Bucar F, Heiß EH, Dirsch VM, Atanasov AG
Molecular nutrition & food research 2018 Jul;62(14):e1800011
Molecular nutrition & food research 2018 Jul;62(14):e1800011
Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux.
Wang L, Eftekhari P, Schachner D, Ignatova ID, Palme V, Schilcher N, Ladurner A, Heiss EH, Stangl H, Dirsch VM, Atanasov AG
Scientific reports 2018 Jul 23;8(1):11061
Scientific reports 2018 Jul 23;8(1):11061
Toll-like receptor 2 downregulates the cholesterol efflux by activating the nuclear factor-κB pathway in macrophages and may be a potential therapeutic target for the prevention of atherosclerosis.
Li Y, Shen S, Ding S, Wang L
Experimental and therapeutic medicine 2018 Jan;15(1):198-204
Experimental and therapeutic medicine 2018 Jan;15(1):198-204
Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity.
Cuffe H, Liu M, Key CC, Boudyguina E, Sawyer JK, Weckerle A, Bashore A, Fried SK, Chung S, Parks JS
Arteriosclerosis, thrombosis, and vascular biology 2018 Apr;38(4):733-743
Arteriosclerosis, thrombosis, and vascular biology 2018 Apr;38(4):733-743
Macrophage deficiency of miR-21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis.
Canfrán-Duque A, Rotllan N, Zhang X, Fernández-Fuertes M, Ramírez-Hidalgo C, Araldi E, Daimiel L, Busto R, Fernández-Hernando C, Suárez Y
EMBO molecular medicine 2017 Sep;9(9):1244-1262
EMBO molecular medicine 2017 Sep;9(9):1244-1262
ABCG1 regulates pulmonary surfactant metabolism in mice and men.
de Aguiar Vallim TQ, Lee E, Merriott DJ, Goulbourne CN, Cheng J, Cheng A, Gonen A, Allen RM, Palladino END, Ford DA, Wang T, Baldán Á, Tarling EJ
Journal of lipid research 2017 May;58(5):941-954
Journal of lipid research 2017 May;58(5):941-954
Activation of PPARγ does not contribute to macrophage ABCA1 expression and ABCA1-mediated cholesterol efflux to apoAI.
Jiang M, Li X
Biochemical and biophysical research communications 2017 Jan 22;482(4):849-856
Biochemical and biophysical research communications 2017 Jan 22;482(4):849-856
Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease.
Mariani MM, Malm T, Lamb R, Jay TR, Neilson L, Casali B, Medarametla L, Landreth GE
Scientific reports 2017 Feb 16;7:42270
Scientific reports 2017 Feb 16;7:42270
Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages.
Wang L, Palme V, Rotter S, Schilcher N, Cukaj M, Wang D, Ladurner A, Heiss EH, Stangl H, Dirsch VM, Atanasov AG
Molecular nutrition & food research 2017 Apr;61(4)
Molecular nutrition & food research 2017 Apr;61(4)
Quercetin stabilizes apolipoprotein E and reduces brain Aβ levels in amyloid model mice.
Zhang X, Hu J, Zhong L, Wang N, Yang L, Liu CC, Li H, Wang X, Zhou Y, Zhang Y, Xu H, Bu G, Zhuang J
Neuropharmacology 2016 Sep;108:179-92
Neuropharmacology 2016 Sep;108:179-92
MicroRNA-33 Regulates the Innate Immune Response via ATP Binding Cassette Transporter-mediated Remodeling of Membrane Microdomains.
Lai L, Azzam KM, Lin WC, Rai P, Lowe JM, Gabor KA, Madenspacher JH, Aloor JJ, Parks JS, Näär AM, Fessler MB
The Journal of biological chemistry 2016 Sep 9;291(37):19651-60
The Journal of biological chemistry 2016 Sep 9;291(37):19651-60
Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis.
Cheng HY, Gaddis DE, Wu R, McSkimming C, Haynes LD, Taylor AM, McNamara CA, Sorci-Thomas M, Hedrick CC
The Journal of clinical investigation 2016 Sep 1;126(9):3236-46
The Journal of clinical investigation 2016 Sep 1;126(9):3236-46
Ursolic acid enhances macrophage autophagy and attenuates atherogenesis.
Leng S, Iwanowycz S, Saaoud F, Wang J, Wang Y, Sergin I, Razani B, Fan D
Journal of lipid research 2016 Jun;57(6):1006-16
Journal of lipid research 2016 Jun;57(6):1006-16
Effect of vildagliptin and pravastatin combination on cholesterol efflux in adipocytes.
Mostafa AM, Hamdy NM, Abdel-Rahman SZ, El-Mesallamy HO
IUBMB life 2016 Jul;68(7):535-43
IUBMB life 2016 Jul;68(7):535-43
Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550-Brief Report.
Tarling EJ, Edwards PA
Arteriosclerosis, thrombosis, and vascular biology 2016 Jul;36(7):1323-7
Arteriosclerosis, thrombosis, and vascular biology 2016 Jul;36(7):1323-7
ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression.
Aryal B, Rotllan N, Araldi E, Ramírez CM, He S, Chousterman BG, Fenn AM, Wanschel A, Madrigal-Matute J, Warrier N, Martín-Ventura JL, Swirski FK, Suárez Y, Fernández-Hernando C
Nature communications 2016 Jul 27;7:12313
Nature communications 2016 Jul 27;7:12313
Lanatoside C Promotes Foam Cell Formation and Atherosclerosis.
Shi H, Mao X, Zhong Y, Liu Y, Zhao X, Yu K, Zhu R, Wei Y, Zhu J, Sun H, Mao Y, Zeng Q
Scientific reports 2016 Jan 29;6:20154
Scientific reports 2016 Jan 29;6:20154
β Common Receptor Mediates Erythropoietin-Conferred Protection on OxLDL-Induced Lipid Accumulation and Inflammation in Macrophages.
Lee TS, Lu KY, Yu YB, Lee HT, Tsai FC
Mediators of inflammation 2015;2015:439759
Mediators of inflammation 2015;2015:439759
Adipocyte ATP-binding cassette G1 promotes triglyceride storage, fat mass growth, and human obesity.
Frisdal E, Le Lay S, Hooton H, Poupel L, Olivier M, Alili R, Plengpanich W, Villard EF, Gilibert S, Lhomme M, Superville A, Miftah-Alkhair L, Chapman MJ, Dallinga-Thie GM, Venteclef N, Poitou C, Tordjman J, Lesnik P, Kontush A, Huby T, Dugail I, Clement K, Guerin M, Le Goff W
Diabetes 2015 Mar;64(3):840-55
Diabetes 2015 Mar;64(3):840-55
Enolase is regulated by Liver X Receptors.
De Boussac H, Maqdasy S, Trousson A, Zelcer N, Volle DH, Lobaccaro JM, Baron S
Steroids 2015 Jul;99(Pt B):266-71
Steroids 2015 Jul;99(Pt B):266-71
Pathways of cholesterol homeostasis in mouse retina responsive to dietary and pharmacologic treatments.
Zheng W, Mast N, Saadane A, Pikuleva IA
Journal of lipid research 2015 Jan;56(1):81-97
Journal of lipid research 2015 Jan;56(1):81-97
RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes.
Daffu G, Shen X, Senatus L, Thiagarajan D, Abedini A, Hurtado Del Pozo C, Rosario R, Song F, Friedman RA, Ramasamy R, Schmidt AM
Diabetes 2015 Dec;64(12):4046-60
Diabetes 2015 Dec;64(12):4046-60
Glucagon-like peptide 1 (GLP-1)-based therapy upregulates LXR-ABCA1/ABCG1 cascade in adipocytes.
Mostafa AM, Hamdy NM, El-Mesallamy HO, Abdel-Rahman SZ
Biochemical and biophysical research communications 2015 Dec 25;468(4):900-5
Biochemical and biophysical research communications 2015 Dec 25;468(4):900-5
Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate.
Matsuo K, Yamamoto S, Wakamatsu T, Takahashi Y, Kawamura K, Kaneko Y, Goto S, Kazama JJ, Narita I
Toxins 2015 Aug 14;7(8):3155-66
Toxins 2015 Aug 14;7(8):3155-66
Purple perilla extracts with α-asarone enhance cholesterol efflux from oxidized LDL-exposed macrophages.
Park SH, Paek JH, Shin D, Lee JY, Lim SS, Kang YH
International journal of molecular medicine 2015 Apr;35(4):957-65
International journal of molecular medicine 2015 Apr;35(4):957-65
[ABCG1 transporter gene expression in peripheral blood mononuclear cells of patients with atherosclerosis].
Miroshnikova VV, Demina EP, Maĭorov NV, Davydenko VV, Kur'ianov PS, Vavilov VN, Vinogradov AG, Denisenko AD, Shvartsman AL
Tsitologiia 2014;56(3):234-40
Tsitologiia 2014;56(3):234-40
Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.
Tai LM, Koster KP, Luo J, Lee SH, Wang YT, Collins NC, Ben Aissa M, Thatcher GR, LaDu MJ
The Journal of biological chemistry 2014 Oct 31;289(44):30538-55
The Journal of biological chemistry 2014 Oct 31;289(44):30538-55
Fumigaclavine C activates PPARγ pathway and attenuates atherogenesis in ApoE-deficient mice.
Du RH, Qin SY, Shi LS, Zhou ZQ, Zhu XY, Liu J, Tan RX, Cao W
Atherosclerosis 2014 May;234(1):120-8
Atherosclerosis 2014 May;234(1):120-8
MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo.
Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K
Scientific reports 2014 Jun 16;4:5312
Scientific reports 2014 Jun 16;4:5312
Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles.
Kuo CH, Leon L, Chung EJ, Huang RT, Sontag TJ, Reardon CA, Getz GS, Tirrell M, Fang Y
Journal of materials chemistry. B 2014 Dec 14;2(46):8142-8153
Journal of materials chemistry. B 2014 Dec 14;2(46):8142-8153
Effect of apoA-I Mutations in the Capacity of Reconstituted HDL to Promote ABCG1-Mediated Cholesterol Efflux.
Daniil G, Zannis VI, Chroni A
PloS one 2013;8(6):e67993
PloS one 2013;8(6):e67993
Inhibition of mitogen-activated protein kinase Erk1/2 promotes protein degradation of ATP binding cassette transporters A1 and G1 in CHO and HuH7 cells.
Mulay V, Wood P, Manetsch M, Darabi M, Cairns R, Hoque M, Chan KC, Reverter M, Alvarez-Guaita A, Rye KA, Rentero C, Heeren J, Enrich C, Grewal T
PloS one 2013;8(4):e62667
PloS one 2013;8(4):e62667
Bone marrow deficiency of MCPIP1 results in severe multi-organ inflammation but diminishes atherogenesis in hyperlipidemic mice.
Yu F, Du F, Wang Y, Huang S, Miao R, Major AS, Murphy EA, Fu M, Fan D
PloS one 2013;8(11):e80089
PloS one 2013;8(11):e80089
The Impairment of Macrophage-to-Feces Reverse Cholesterol Transport during Inflammation Does Not Depend on Serum Amyloid A.
de Beer MC, Wroblewski JM, Noffsinger VP, Ji A, Meyer JM, van der Westhuyzen DR, de Beer FC, Webb NR
Journal of lipids 2013;2013:283486
Journal of lipids 2013;2013:283486
Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death.
Okabe A, Urano Y, Itoh S, Suda N, Kotani R, Nishimura Y, Saito Y, Noguchi N
Redox biology 2013;2:28-35
Redox biology 2013;2:28-35
Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.
Doddapattar P, Radović B, Patankar JV, Obrowsky S, Jandl K, Nusshold C, Kolb D, Vujić N, Doshi L, Chandak PG, Goeritzer M, Ahammer H, Hoefler G, Sattler W, Kratky D
Molecular nutrition & food research 2013 Oct;57(10):1718-28
Molecular nutrition & food research 2013 Oct;57(10):1718-28
Vitamin E secretion by Caco-2 monolayers to APOA1, but not to HDL, is vitamer selective.
Nicod N, Parker RS
The Journal of nutrition 2013 Oct;143(10):1565-72
The Journal of nutrition 2013 Oct;143(10):1565-72
MCP-1 impacts RCT by repressing ABCA1, ABCG1, and SR-BI through PI3K/Akt posttranslational regulation in HepG2 cells.
Huang CX, Zhang YL, Wang JF, Jiang JY, Bao JL
Journal of lipid research 2013 May;54(5):1231-40
Journal of lipid research 2013 May;54(5):1231-40
Characterization of palmitoylation of ATP binding cassette transporter G1: effect on protein trafficking and function.
Gu HM, Li G, Gao X, Berthiaume LG, Zhang DW
Biochimica et biophysica acta 2013 Jun;1831(6):1067-78
Biochimica et biophysica acta 2013 Jun;1831(6):1067-78
Control of angiogenesis by AIBP-mediated cholesterol efflux.
Fang L, Choi SH, Baek JS, Liu C, Almazan F, Ulrich F, Wiesner P, Taleb A, Deer E, Pattison J, Torres-Vázquez J, Li AC, Miller YI
Nature 2013 Jun 6;498(7452):118-22
Nature 2013 Jun 6;498(7452):118-22
Knock-down of the oxysterol receptor LXRα impairs cholesterol efflux in human primary macrophages: lack of compensation by LXRβ activation.
Ishibashi M, Filomenko R, Rébé C, Chevriaux A, Varin A, Derangère V, Bessède G, Gambert P, Lagrost L, Masson D
Biochemical pharmacology 2013 Jul 1;86(1):122-9
Biochemical pharmacology 2013 Jul 1;86(1):122-9
Molecular mechanisms responsible for the reduced expression of cholesterol transporters from macrophages by low-dose endotoxin.
Maitra U, Li L
Arteriosclerosis, thrombosis, and vascular biology 2013 Jan;33(1):24-33
Arteriosclerosis, thrombosis, and vascular biology 2013 Jan;33(1):24-33
Cholesterol efflux is differentially regulated in neurons and astrocytes: implications for brain cholesterol homeostasis.
Chen J, Zhang X, Kusumo H, Costa LG, Guizzetti M
Biochimica et biophysica acta 2013 Feb;1831(2):263-75
Biochimica et biophysica acta 2013 Feb;1831(2):263-75
Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice.
Khan OM, Akula MK, Skålen K, Karlsson C, Ståhlman M, Young SG, Borén J, Bergo MO
Circulation 2013 Feb 19;127(7):782-90
Circulation 2013 Feb 19;127(7):782-90
Overexpression of stearoyl-coenzyme A desaturase 1 in macrophages promotes reverse cholesterol transport.
Nakaya K, Ayaori M, Uto-Kondo H, Sotherden GM, Nishida T, Katamoto H, Miura Y, Takiguchi S, Yakushiji E, Iizuka M, Ogura M, Sasaki M, Yogo M, Komatsu T, Adachi T, Maruyama C, Ikewaki K
Biochimica et biophysica acta 2013 Aug;1831(8):1402-11
Biochimica et biophysica acta 2013 Aug;1831(8):1402-11
Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling.
Zhou MS, Chadipiralla K, Mendez AJ, Jaimes EA, Silverstein RL, Webster K, Raij L
American journal of physiology. Heart and circulatory physiology 2013 Aug 15;305(4):H563-74
American journal of physiology. Heart and circulatory physiology 2013 Aug 15;305(4):H563-74
The anti-proliferative and pro-apoptotic effects of the trans9, trans11 conjugated linoleic acid isomer on MCF-7 breast cancer cells are associated with LXR activation.
El Roz A, Bard JM, Huvelin JM, Nazih H
Prostaglandins, leukotrienes, and essential fatty acids 2013 Apr;88(4):265-72
Prostaglandins, leukotrienes, and essential fatty acids 2013 Apr;88(4):265-72
Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1.
Meurs I, Calpe-Berdiel L, Habets KL, Zhao Y, Korporaal SJ, Mommaas AM, Josselin E, Hildebrand RB, Ye D, Out R, Kuiper J, Van Berkel TJ, Chimini G, Van Eck M
PloS one 2012;7(3):e30984
PloS one 2012;7(3):e30984
Astaxanthin enhances ATP-binding cassette transporter A1/G1 expressions and cholesterol efflux from macrophages.
Iizuka M, Ayaori M, Uto-Kondo H, Yakushiji E, Takiguchi S, Nakaya K, Hisada T, Sasaki M, Komatsu T, Yogo M, Kishimoto Y, Kondo K, Ikewaki K
Journal of nutritional science and vitaminology 2012;58(2):96-104
Journal of nutritional science and vitaminology 2012;58(2):96-104
Astaxanthin enhances ATP-binding cassette transporter A1/G1 expressions and cholesterol efflux from macrophages.
Iizuka M, Ayaori M, Uto-Kondo H, Yakushiji E, Takiguchi S, Nakaya K, Hisada T, Sasaki M, Komatsu T, Yogo M, Kishimoto Y, Kondo K, Ikewaki K
Journal of nutritional science and vitaminology 2012;58(2):96-104
Journal of nutritional science and vitaminology 2012;58(2):96-104
Human ATP-binding cassette G1 controls macrophage lipoprotein lipase bioavailability and promotes foam cell formation.
Olivier M, Tanck MW, Out R, Villard EF, Lammers B, Bouchareychas L, Frisdal E, Superville A, Van Berkel T, Kastelein JJ, Eck MV, Jukema JW, Chapman MJ, Dallinga-Thie GM, Guerin M, Le Goff W
Arteriosclerosis, thrombosis, and vascular biology 2012 Sep;32(9):2223-31
Arteriosclerosis, thrombosis, and vascular biology 2012 Sep;32(9):2223-31
Protein kinase A modulates the activity of a major human isoform of ABCG1.
Gelissen IC, Sharpe LJ, Sandoval C, Rao G, Kockx M, Kritharides L, Jessup W, Brown AJ
Journal of lipid research 2012 Oct;53(10):2133-40
Journal of lipid research 2012 Oct;53(10):2133-40
Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages.
Ku CS, Park Y, Coleman SL, Lee J
The Journal of nutritional biochemistry 2012 Oct;23(10):1271-6
The Journal of nutritional biochemistry 2012 Oct;23(10):1271-6
HDL and ApoA-I inhibit antigen presentation-mediated T cell activation by disrupting lipid rafts in antigen presenting cells.
Wang SH, Yuan SG, Peng DQ, Zhao SP
Atherosclerosis 2012 Nov;225(1):105-14
Atherosclerosis 2012 Nov;225(1):105-14
Keratinocyte ATP binding cassette transporter expression is regulated by ultraviolet light.
Markó L, Paragh G, Ugocsai P, Boettcher A, Vogt T, Schling P, Balogh A, Tarabin V, Orsó E, Wikonkál N, Mandl J, Remenyik E, Schmitz G
Journal of photochemistry and photobiology. B, Biology 2012 Nov 5;116:79-88
Journal of photochemistry and photobiology. B, Biology 2012 Nov 5;116:79-88
Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis.
Zhao JF, Ching LC, Huang YC, Chen CY, Chiang AN, Kou YR, Shyue SK, Lee TS
Molecular nutrition & food research 2012 May;56(5):691-701
Molecular nutrition & food research 2012 May;56(5):691-701
Liver X receptor activation attenuates inflammatory response and protects cholinergic neurons in APP/PS1 transgenic mice.
Cui W, Sun Y, Wang Z, Xu C, Peng Y, Li R
Neuroscience 2012 May 17;210:200-10
Neuroscience 2012 May 17;210:200-10
Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI.
Ji A, Wroblewski JM, Cai L, de Beer MC, Webb NR, van der Westhuyzen DR
Journal of lipid research 2012 Mar;53(3):446-455
Journal of lipid research 2012 Mar;53(3):446-455
ABCA17 mediates sterol efflux from mouse spermatozoa plasma membranes.
Morales CR, Ni X, Smith CE, Inagaki N, Hermo L
Histology and histopathology 2012 Mar;27(3):317-28
Histology and histopathology 2012 Mar;27(3):317-28
Obesity and weight loss result in increased adipose tissue ABCG1 expression in db/db mice.
Edgel KA, McMillen TS, Wei H, Pamir N, Houston BA, Caldwell MT, Mai PO, Oram JF, Tang C, Leboeuf RC
Biochimica et biophysica acta 2012 Mar;1821(3):425-34
Biochimica et biophysica acta 2012 Mar;1821(3):425-34
Phospholipase A(2)-modified low-density lipoprotein activates liver X receptor in human macrophages.
Morbitzer D, Namgaladze D, Brüne B
Cell biochemistry and biophysics 2012 Jun;63(2):143-9
Cell biochemistry and biophysics 2012 Jun;63(2):143-9
PAPP-A negatively regulates ABCA1, ABCG1 and SR-B1 expression by inhibiting LXRα through the IGF-I-mediated signaling pathway.
Tang SL, Chen WJ, Yin K, Zhao GJ, Mo ZC, Lv YC, Ouyang XP, Yu XH, Kuang HJ, Jiang ZS, Fu YC, Tang CK
Atherosclerosis 2012 Jun;222(2):344-54
Atherosclerosis 2012 Jun;222(2):344-54
Overexpression of ABCG1 protein attenuates arteriosclerosis and endothelial dysfunction in atherosclerotic rabbits.
Münch G, Bültmann A, Li Z, Holthoff HP, Ullrich J, Wagner S, Ungerer M
Heart international 2012 Jun 5;7(2):e12
Heart international 2012 Jun 5;7(2):e12
LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis.
El Roz A, Bard JM, Huvelin JM, Nazih H
Anticancer research 2012 Jul;32(7):3007-13
Anticancer research 2012 Jul;32(7):3007-13
MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-/- mice.
Horie T, Baba O, Kuwabara Y, Chujo Y, Watanabe S, Kinoshita M, Horiguchi M, Nakamura T, Chonabayashi K, Hishizawa M, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K
Journal of the American Heart Association 2012 Dec;1(6):e003376
Journal of the American Heart Association 2012 Dec;1(6):e003376
Involvement of cholesterol efflux pathway in the control of cardiomyocytes cholesterol homeostasis.
Reboulleau A, Robert V, Vedie B, Doublet A, Grynberg A, Paul JL, Fournier N
Journal of molecular and cellular cardiology 2012 Aug;53(2):196-205
Journal of molecular and cellular cardiology 2012 Aug;53(2):196-205
Effect of 6-O-α-maltosyl-β cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells.
Okada Y, Ueyama K, Nishikawa J, Semma M, Ichikawa A
Carbohydrate research 2012 Aug 1;357:68-74
Carbohydrate research 2012 Aug 1;357:68-74
Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages.
Ayaori M, Yakushiji E, Ogura M, Nakaya K, Hisada T, Uto-Kondo H, Takiguchi S, Terao Y, Sasaki M, Komatsu T, Iizuka M, Yogo M, Uehara Y, Kagechika H, Nakanishi T, Ikewaki K
Biochimica et biophysica acta 2012 Apr;1821(4):561-72
Biochimica et biophysica acta 2012 Apr;1821(4):561-72
The effect of 17{beta}-estradiol on cholesterol content in human macrophages is influenced by the lipoprotein milieu.
Corcoran MP, Lichtenstein AH, Meydani M, Dillard A, Schaefer EJ, Lamon-Fava S
Journal of molecular endocrinology 2011;47(1):109-17
Journal of molecular endocrinology 2011;47(1):109-17
Retinoic acid isomers up-regulate ATP binding cassette A1 and G1 and cholesterol efflux in rat astrocytes: implications for their therapeutic and teratogenic effects.
Chen J, Costa LG, Guizzetti M
The Journal of pharmacology and experimental therapeutics 2011 Sep;338(3):870-8
The Journal of pharmacology and experimental therapeutics 2011 Sep;338(3):870-8
Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1.
Iborra RT, Machado-Lima A, Castilho G, Nunes VS, Abdalla DS, Nakandakare ER, Passarelli M
Lipids in health and disease 2011 Sep 29;10:172
Lipids in health and disease 2011 Sep 29;10:172
Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice.
Nagashima M, Watanabe T, Terasaki M, Tomoyasu M, Nohtomi K, Kim-Kaneyama J, Miyazaki A, Hirano T
Diabetologia 2011 Oct;54(10):2649-59
Diabetologia 2011 Oct;54(10):2649-59
Scavenger receptor SR-BI in macrophage lipid metabolism.
Ji A, Meyer JM, Cai L, Akinmusire A, de Beer MC, Webb NR, van der Westhuyzen DR
Atherosclerosis 2011 Jul;217(1):106-12
Atherosclerosis 2011 Jul;217(1):106-12
Modulation of macrophage fatty acid content and composition by exposure to dyslipidemic serum in vitro.
Wong BX, Kyle RA, Croft KD, Quinn CM, Jessup W, Yeap BB
Lipids 2011 Apr;46(4):371-80
Lipids 2011 Apr;46(4):371-80
Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity.
Aye IL, Waddell BJ, Mark PJ, Keelan JA
Biochimica et biophysica acta 2010 Sep;1801(9):1013-24
Biochimica et biophysica acta 2010 Sep;1801(9):1013-24
The structural basis for membrane binding and pore formation by lymphocyte perforin.
Law RH, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, D'Angelo ME, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird PI, Trapani JA, Saibil HR, Whisstock JC
Nature 2010 Nov 18;468(7322):447-51
Nature 2010 Nov 18;468(7322):447-51
Coffee consumption enhances high-density lipoprotein-mediated cholesterol efflux in macrophages.
Uto-Kondo H, Ayaori M, Ogura M, Nakaya K, Ito M, Suzuki A, Takiguchi S, Yakushiji E, Terao Y, Ozasa H, Hisada T, Sasaki M, Ohsuzu F, Ikewaki K
Circulation research 2010 Mar 5;106(4):779-87
Circulation research 2010 Mar 5;106(4):779-87
SR-BI, CD36, and caveolin-1 contribute positively to cholesterol efflux in hepatic cells.
Truong TQ, Aubin D, Falstrault L, Brodeur MR, Brissette L
Cell biochemistry and function 2010 Aug;28(6):480-9
Cell biochemistry and function 2010 Aug;28(6):480-9
LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner.
Ouvrier A, Cadet R, Vernet P, Laillet B, Chardigny JM, Lobaccaro JM, Drevet JR, Saez F
Journal of lipid research 2009 Sep;50(9):1766-75
Journal of lipid research 2009 Sep;50(9):1766-75
Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2.
Welch C, Santra MK, El-Assaad W, Zhu X, Huber WE, Keys RA, Teodoro JG, Green MR
Cancer research 2009 Sep 1;69(17):6782-9
Cancer research 2009 Sep 1;69(17):6782-9
Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways.
Nagelin MH, Srinivasan S, Nadler JL, Hedrick CC
The Journal of biological chemistry 2009 Nov 6;284(45):31303-14
The Journal of biological chemistry 2009 Nov 6;284(45):31303-14
High-density lipoprotein transport through aortic endothelial cells involves scavenger receptor BI and ATP-binding cassette transporter G1.
Rohrer L, Ohnsorg PM, Lehner M, Landolt F, Rinninger F, von Eckardstein A
Circulation research 2009 May 22;104(10):1142-50
Circulation research 2009 May 22;104(10):1142-50
Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice.
Liu J, Huan C, Chakraborty M, Zhang H, Lu D, Kuo MS, Cao G, Jiang XC
Circulation research 2009 Jul 31;105(3):295-303
Circulation research 2009 Jul 31;105(3):295-303
Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity.
Nakanishi S, Vikstedt R, Söderlund S, Lee-Rueckert M, Hiukka A, Ehnholm C, Muilu M, Metso J, Naukkarinen J, Palotie L, Kovanen PT, Jauhiainen M, Taskinen MR
Journal of lipid research 2009 Feb;50(2):183-92
Journal of lipid research 2009 Feb;50(2):183-92
Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages.
Hongo S, Watanabe T, Arita S, Kanome T, Kageyama H, Shioda S, Miyazaki A
American journal of physiology. Endocrinology and metabolism 2009 Aug;297(2):E474-82
American journal of physiology. Endocrinology and metabolism 2009 Aug;297(2):E474-82
Insulin stimulates the expression of carbohydrate response element binding protein (ChREBP) by attenuating the repressive effect of Pit-1, Oct-1/Oct-2, and Unc-86 homeodomain protein octamer transcription factor-1.
Sirek AS, Liu L, Naples M, Adeli K, Ng DS, Jin T
Endocrinology 2009 Aug;150(8):3483-92
Endocrinology 2009 Aug;150(8):3483-92
Dietary soy protein isolate attenuates metabolic syndrome in rats via effects on PPAR, LXR, and SREBP signaling.
Ronis MJ, Chen Y, Badeaux J, Badger TM
The Journal of nutrition 2009 Aug;139(8):1431-8
The Journal of nutrition 2009 Aug;139(8):1431-8
Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis.
Xu G, Watanabe T, Iso Y, Koba S, Sakai T, Nagashima M, Arita S, Hongo S, Ota H, Kobayashi Y, Miyazaki A, Hirano T
Circulation research 2009 Aug 28;105(5):500-10
Circulation research 2009 Aug 28;105(5):500-10
CD36-mediated cholesterol efflux is associated with PPARgamma activation via a MAPK-dependent COX-2 pathway in macrophages.
Bujold K, Rhainds D, Jossart C, Febbraio M, Marleau S, Ong H
Cardiovascular research 2009 Aug 1;83(3):457-64
Cardiovascular research 2009 Aug 1;83(3):457-64
LXR-induced reverse cholesterol transport in human airway smooth muscle is mediated exclusively by ABCA1.
Delvecchio CJ, Bilan P, Nair P, Capone JP
American journal of physiology. Lung cellular and molecular physiology 2008 Nov;295(5):L949-57
American journal of physiology. Lung cellular and molecular physiology 2008 Nov;295(5):L949-57
Reduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitus.
Mauldin JP, Nagelin MH, Wojcik AJ, Srinivasan S, Skaflen MD, Ayers CR, McNamara CA, Hedrick CC
Circulation 2008 May 27;117(21):2785-92
Circulation 2008 May 27;117(21):2785-92
A critical role for ABCG1 in macrophage inflammation and lung homeostasis.
Wojcik AJ, Skaflen MD, Srinivasan S, Hedrick CC
Journal of immunology (Baltimore, Md. : 1950) 2008 Mar 15;180(6):4273-82
Journal of immunology (Baltimore, Md. : 1950) 2008 Mar 15;180(6):4273-82
A critical role for ABCG1 in macrophage inflammation and lung homeostasis.
Wojcik AJ, Skaflen MD, Srinivasan S, Hedrick CC
Journal of immunology (Baltimore, Md. : 1950) 2008 Mar 15;180(6):4273-82
Journal of immunology (Baltimore, Md. : 1950) 2008 Mar 15;180(6):4273-82
ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo.
Burgess BL, Parkinson PF, Racke MM, Hirsch-Reinshagen V, Fan J, Wong C, Stukas S, Theroux L, Chan JY, Donkin J, Wilkinson A, Balik D, Christie B, Poirier J, Lütjohann D, Demattos RB, Wellington CL
Journal of lipid research 2008 Jun;49(6):1254-67
Journal of lipid research 2008 Jun;49(6):1254-67
Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux.
Ouimet M, Wang MD, Cadotte N, Ho K, Marcel YL
Arteriosclerosis, thrombosis, and vascular biology 2008 Jun;28(6):1144-50
Arteriosclerosis, thrombosis, and vascular biology 2008 Jun;28(6):1144-50
Lipidation of apolipoprotein A-I by ATP-binding cassette transporter (ABC) A1 generates an interaction partner for ABCG1 but not for scavenger receptor BI.
Lorenzi I, von Eckardstein A, Radosavljevic S, Rohrer L
Biochimica et biophysica acta 2008 Jun-Jul;1781(6-7):306-13
Biochimica et biophysica acta 2008 Jun-Jul;1781(6-7):306-13
ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2.
Tarr PT, Edwards PA
Journal of lipid research 2008 Jan;49(1):169-82
Journal of lipid research 2008 Jan;49(1):169-82
SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL.
Yvan-Charvet L, Pagler TA, Wang N, Senokuchi T, Brundert M, Li H, Rinninger F, Tall AR
Journal of lipid research 2008 Jan;49(1):107-14
Journal of lipid research 2008 Jan;49(1):107-14
Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1.
Out R, Jessup W, Le Goff W, Hoekstra M, Gelissen IC, Zhao Y, Kritharides L, Chimini G, Kuiper J, Chapman MJ, Huby T, Van Berkel TJ, Van Eck M
Circulation research 2008 Jan 4;102(1):113-20
Circulation research 2008 Jan 4;102(1):113-20
Genetic deletion of low density lipoprotein receptor impairs sterol-induced mouse macrophage ABCA1 expression. A new SREBP1-dependent mechanism.
Zhou X, He W, Huang Z, Gotto AM Jr, Hajjar DP, Han J
The Journal of biological chemistry 2008 Jan 25;283(4):2129-38
The Journal of biological chemistry 2008 Jan 25;283(4):2129-38
Biogenesis of HDL by SAA is dependent on ABCA1 in the liver in vivo.
Hu W, Abe-Dohmae S, Tsujita M, Iwamoto N, Ogikubo O, Otsuka T, Kumon Y, Yokoyama S
Journal of lipid research 2008 Feb;49(2):386-93
Journal of lipid research 2008 Feb;49(2):386-93
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.
Wahrle SE, Jiang H, Parsadanian M, Kim J, Li A, Knoten A, Jain S, Hirsch-Reinshagen V, Wellington CL, Bales KR, Paul SM, Holtzman DM
The Journal of clinical investigation 2008 Feb;118(2):671-82
The Journal of clinical investigation 2008 Feb;118(2):671-82
The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein.
Tansley GH, Burgess BL, Bryan MT, Su Y, Hirsch-Reinshagen V, Pearce J, Chan JY, Wilkinson A, Evans J, Naus KE, McIsaac S, Bromley K, Song W, Yang HC, Wang N, DeMattos RB, Wellington CL
Journal of lipid research 2007 May;48(5):1022-34
Journal of lipid research 2007 May;48(5):1022-34
Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways.
Wang MD, Kiss RS, Franklin V, McBride HM, Whitman SC, Marcel YL
Journal of lipid research 2007 Mar;48(3):633-45
Journal of lipid research 2007 Mar;48(3):633-45
PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine.
Li T, Chen W, Chiang JY
Journal of lipid research 2007 Feb;48(2):373-84
Journal of lipid research 2007 Feb;48(2):373-84
Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with Abcg1-/- bone marrow.
Ranalletta M, Wang N, Han S, Yvan-Charvet L, Welch C, Tall AR
Arteriosclerosis, thrombosis, and vascular biology 2006 Oct;26(10):2308-15
Arteriosclerosis, thrombosis, and vascular biology 2006 Oct;26(10):2308-15
Transcriptional repression of ATP-binding cassette transporter A1 gene in macrophages: a novel atherosclerotic effect of angiotensin II.
Takata Y, Chu V, Collins AR, Lyon CJ, Wang W, Blaschke F, Bruemmer D, Caglayan E, Daley W, Higaki J, Fishbein MC, Tangirala RK, Law RE, Hsueh WA
Circulation research 2005 Oct 28;97(9):e88-96
Circulation research 2005 Oct 28;97(9):e88-96
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ABCG1 Antibody [NB400-132] - Detection of ABCG1 in J774 mouse macrophages. Image provided by Dr. Angeliki Chroni of the National Centre for Scientific Research Demokritos.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ABCG1 Antibody [NB400-132] - Raw 264.7 (A), and Raw 264.7 + 10uM T09 18 hr (B) cell lysate using ABCG1 antibody at 2 ug/mL.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ABCG1 Antibody [NB400-132] - Detection of ABCG1 in mouse peritoneal macrophages. 1: untreated mouse peritoneal macrophages, 2: 22-(R)-hydrocholesterol treated macrophages, 3: T0901713 treated macrophages, 4: T091713 treated macrophages.
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- Novus Biologicals (provider)
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- Experimental details
- Western Blot: ABCG1 Antibody [NB400-132] - SAA has little impact on the impairment in biliary and fecal excretion of macrophage-derived 3H-cholesterol during endotoxemia. WT and SAAKO mice were injected subcutaneously with PBS or 0.8 ug/g LPS as indicated, followed 4 hr later by intraperitoneal injection of 3H-cholesterol-labeled J774 macrophages. ABCG1 in liver lysates (40 ug protein) was identified by immunoblotting and quantified by densitometry. Results from each of the 3 experiments (n = 4-5 per group per experiment) were expressed relative to PBS-injected WT mice after normalization to beta-actin. A representative western blot is shown. Image collected and cropped by CiteAb from the following publication (http://www.hindawi.com/journals/jl/2013/283486/), licensed under a CC-BY licence.
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- Novus Biologicals (provider)
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- Western Blot: ABCG1 Antibody [NB400-132] - ABCA-1 protein level in control and glycolaldehydetreated macrophages. J774 macrophages were overloaded with oxidized LDL (50 ug/mL de DMEM) for 48 h. In the last 5h, cells were incubated with 0.25 mM glycolaldehyde (GAD; black bars) and 1 uM LXR agonist (T0901317). Control cells (C; gray bars) were incubated with T0901317 alone. Cells were scrapped into TBS containing protease inhibitors. Equal amounts of cell protein were applied into a 6% polyacrylamide electrophoresis gel and immunoblot was performed utilizing anti ABCA-1 antibody. Data (arbitrary units; n = 4) were corrected per beta-actin Image collected and cropped by CiteAb from the following publication (http://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-10-172), licensed under a CC-BY licence.
Supportive validation
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- Novus Biologicals (provider)
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- Immunohistochemistry-Paraffin: ABCG1 Antibody [NB400-132] - Staining of human lung, alveolar macrophages.
Supportive validation
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- Novus Biologicals (provider)
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- Experimental details
- Flow (Intracellular): ABCG1 Antibody [NB400-132] - RAW 246.7 cells were either untreated (A) or serum starved for 24 hours, and then treated with 1uM TO9 for 24 hours (B). An intracellular stain was performed with NB400-132 (blue) and a matched isotype control NB810-56910 (orange). Cells were fixed with 4% paraformaldehyde, following fixation, cells were permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 5 ug/mL for 30 minutes at room temperature, followed by Goat Anti-Rabbit Dylight 550-conjugated antibody.
