GTPBP4

GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]

Description

GTP binding protein 4

Tissue specificity

Low tissue specificity

Subcell location

Nuclear membrane, Nucleoli, Nucleoli rim

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (988434 - 1019932)

Ensembl ID

ENSG00000107937  (ver. 103.38)

Orthologs

Mouse Gtpbp4: ENSMUSG00000021149

UniProt

Q9BZE4

neXtProt

NX_Q9BZE4

Human splice variants
Mouse splice variants

Protein structure