Antibody data
- Antibody Data
- Antigen structure
- References [20]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 12627-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12627-1-AP, RRID:AB_2271200
- Product name
- SUCLA2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SUCLA2 antibody (Cat. #12627-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas.
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.
SUCLG2 Regulates Mitochondrial Dysfunction through Succinylation in Lung Adenocarcinoma.
Investigations into photoreceptor energy metabolism during experimental retinal detachment.
Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging.
MUC1 triggers lineage plasticity of Her2 positive mammary tumors.
Quantitative subcellular acyl-CoA analysis reveals distinct nuclear metabolism and isoleucine-dependent histone propionylation.
Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.
Exclusive neuronal detection of KGDHC-specific subunits in the adult human brain cortex despite pancellular protein lysine succinylation.
Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion.
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.
Knockdown of Sucla2 decreases the viability of mouse spermatocytes by inducing apoptosis through injury of the mitochondrial function of cells.
Two transgenic mouse models for β-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations.
Succinate-CoA ligase deficiency due to mutations in SUCLA2 and SUCLG1: phenotype and genotype correlations in 71 patients.
2,2',4,4'-Tetrabromodiphenyl ether disrupts spermatogenesis, impairs mitochondrial function and induces apoptosis of early leptotene spermatocytes in rats.
Exclusive neuronal expression of SUCLA2 in the human brain.
Localization of SUCLA2 and SUCLG2 subunits of succinyl CoA ligase within the cerebral cortex suggests the absence of matrix substrate-level phosphorylation in glial cells of the human brain.
Synaptic mitochondria: a brain mitochondria cluster with a specific proteome.
The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation.
Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level phosphorylation.
Gao Y, Long Q, Yang H, Hu Y, Xu Y, Tang C, Gu C, Yong S
Experimental and therapeutic medicine 2023 Nov;26(5):533
Experimental and therapeutic medicine 2023 Nov;26(5):533
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.
Southwell N, Primiano G, Nadkarni V, Attarwala N, Beattie E, Miller D, Alam S, Liparulo I, Shurubor YI, Valentino ML, Carelli V, Servidei S, Gross SS, Manfredi G, Chen Q, D'Aurelio M
EMBO molecular medicine 2023 Jul 10;15(7):e16951
EMBO molecular medicine 2023 Jul 10;15(7):e16951
SUCLG2 Regulates Mitochondrial Dysfunction through Succinylation in Lung Adenocarcinoma.
Hu Q, Xu J, Wang L, Yuan Y, Luo R, Gan M, Wang K, Zhao T, Wang Y, Han T, Wang JB
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(35):e2303535
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(35):e2303535
Investigations into photoreceptor energy metabolism during experimental retinal detachment.
Chidlow G, Chan WO, Wood JPM, Casson RJ
Frontiers in cellular neuroscience 2022;16:1036834
Frontiers in cellular neuroscience 2022;16:1036834
Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging.
Yuan M, Wang Y, Wen J, Jing F, Zou Q, Pu Y, Pan T, Cai Z
Aging and disease 2022 Oct 1;13(5):1532-1545
Aging and disease 2022 Oct 1;13(5):1532-1545
MUC1 triggers lineage plasticity of Her2 positive mammary tumors.
Pang Z, Dong X, Deng H, Wang C, Liao X, Liao C, Liao Y, Tian W, Cheng J, Chen G, Yi H, Huang L
Oncogene 2022 May;41(22):3064-3078
Oncogene 2022 May;41(22):3064-3078
Quantitative subcellular acyl-CoA analysis reveals distinct nuclear metabolism and isoleucine-dependent histone propionylation.
Trefely S, Huber K, Liu J, Noji M, Stransky S, Singh J, Doan MT, Lovell CD, von Krusenstiern E, Jiang H, Bostwick A, Pepper HL, Izzo L, Zhao S, Xu JP, Bedi KC Jr, Rame JE, Bogner-Strauss JG, Mesaros C, Sidoli S, Wellen KE, Snyder NW
Molecular cell 2022 Jan 20;82(2):447-462.e6
Molecular cell 2022 Jan 20;82(2):447-462.e6
Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.
Wang XH, Xu S, Zhou XY, Zhao R, Lin Y, Cao J, Zang WD, Tao H, Xu W, Li MQ, Zhao SM, Jin LP, Zhao JY
Nature communications 2021 Jun 8;12(1):3428
Nature communications 2021 Jun 8;12(1):3428
Exclusive neuronal detection of KGDHC-specific subunits in the adult human brain cortex despite pancellular protein lysine succinylation.
Dobolyi A, Bago A, Palkovits M, Nemeria NS, Jordan F, Doczi J, Ambrus A, Adam-Vizi V, Chinopoulos C
Brain structure & function 2020 Mar;225(2):639-667
Brain structure & function 2020 Mar;225(2):639-667
Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion.
Kohno S, Linn P, Nagatani N, Watanabe Y, Kumar S, Soga T, Takahashi C
Oncogene 2020 Aug;39(34):5690-5707
Oncogene 2020 Aug;39(34):5690-5707
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.
Maio N, Kim KS, Holmes-Hampton G, Singh A, Rouault TA
Haematologica 2019 Sep;104(9):1756-1767
Haematologica 2019 Sep;104(9):1756-1767
Knockdown of Sucla2 decreases the viability of mouse spermatocytes by inducing apoptosis through injury of the mitochondrial function of cells.
Huang S, Wang J, Wang L
Folia histochemica et cytobiologica 2016;54(3):134-142
Folia histochemica et cytobiologica 2016;54(3):134-142
Two transgenic mouse models for β-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations.
Kacso G, Ravasz D, Doczi J, Németh B, Madgar O, Saada A, Ilin P, Miller C, Ostergaard E, Iordanov I, Adams D, Vargedo Z, Araki M, Araki K, Nakahara M, Ito H, Gál A, Molnár MJ, Nagy Z, Patocs A, Adam-Vizi V, Chinopoulos C
The Biochemical journal 2016 Oct 15;473(20):3463-3485
The Biochemical journal 2016 Oct 15;473(20):3463-3485
Succinate-CoA ligase deficiency due to mutations in SUCLA2 and SUCLG1: phenotype and genotype correlations in 71 patients.
Carrozzo R, Verrigni D, Rasmussen M, de Coo R, Amartino H, Bianchi M, Buhas D, Mesli S, Naess K, Born AP, Woldseth B, Prontera P, Batbayli M, Ravn K, Joensen F, Cordelli DM, Santorelli FM, Tulinius M, Darin N, Duno M, Jouvencel P, Burlina A, Stangoni G, Bertini E, Redonnet-Vernhet I, Wibrand F, Dionisi-Vici C, Uusimaa J, Vieira P, Osorio AN, McFarland R, Taylor RW, Holme E, Ostergaard E
Journal of inherited metabolic disease 2016 Mar;39(2):243-52
Journal of inherited metabolic disease 2016 Mar;39(2):243-52
2,2',4,4'-Tetrabromodiphenyl ether disrupts spermatogenesis, impairs mitochondrial function and induces apoptosis of early leptotene spermatocytes in rats.
Huang S, Cui Y, Guo X, Wang L, Li S, Lu Y, Bi Y, Huang X, Lin M, Xia Y, Wang S, Wang X, Zhou Z, Sha J
Reproductive toxicology (Elmsford, N.Y.) 2015 Jan;51:114-24
Reproductive toxicology (Elmsford, N.Y.) 2015 Jan;51:114-24
Exclusive neuronal expression of SUCLA2 in the human brain.
Dobolyi A, Ostergaard E, Bagó AG, Dóczi T, Palkovits M, Gál A, Molnár MJ, Adam-Vizi V, Chinopoulos C
Brain structure & function 2015 Jan;220(1):135-51
Brain structure & function 2015 Jan;220(1):135-51
Localization of SUCLA2 and SUCLG2 subunits of succinyl CoA ligase within the cerebral cortex suggests the absence of matrix substrate-level phosphorylation in glial cells of the human brain.
Dobolyi A, Bagó AG, Gál A, Molnár MJ, Palkovits M, Adam-Vizi V, Chinopoulos C
Journal of bioenergetics and biomembranes 2015 Apr;47(1-2):33-41
Journal of bioenergetics and biomembranes 2015 Apr;47(1-2):33-41
Synaptic mitochondria: a brain mitochondria cluster with a specific proteome.
Völgyi K, Gulyássy P, Háden K, Kis V, Badics K, Kékesi KA, Simor A, Györffy B, Tóth EA, Lubec G, Juhász G, Dobolyi A
Journal of proteomics 2015 Apr 29;120:142-57
Journal of proteomics 2015 Apr 29;120:142-57
The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation.
Kiss G, Konrad C, Doczi J, Starkov AA, Kawamata H, Manfredi G, Zhang SF, Gibson GE, Beal MF, Adam-Vizi V, Chinopoulos C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Jun;27(6):2392-406
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Jun;27(6):2392-406
Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level phosphorylation.
Chinopoulos C, Gerencser AA, Mandi M, Mathe K, Töröcsik B, Doczi J, Turiak L, Kiss G, Konràd C, Vajda S, Vereczki V, Oh RJ, Adam-Vizi V
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Jul;24(7):2405-16
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Jul;24(7):2405-16
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 12627-1-AP(SUCLA2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SUCLA2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SUCLA2. This antibody recognizes human,mouse,rat antigen. The SUCLA2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.