Antibody data
- Antibody Data
- Antigen structure
- References [42]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 13681-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13681-1-AP, RRID:AB_10598321
- Product name
- TFF2 antibody
- Antibody type
- Polyclonal
- Description
- TFF2 antibody (Cat. #13681-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The expression of trefoil factor family member 2 in increased at an acidic pH.
Efficacy and potential therapeutic mechanism of Weiwei decoction on Spasmolytic polypeptide-expressing metaplasia in Helicobacter pylori-infected and Atp4a-knockout mice.
Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids.
YAP targetome reveals activation of SPEM in gastric pre-neoplastic progression and regeneration.
A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach.
Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium.
Systematic identification of cell-fate regulatory programs using a single-cell atlas of mouse development.
Resolving the difference between left-sided and right-sided colorectal cancer by single-cell sequencing.
Glycosylation of MUC6 by α1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy.
Epstein-Barr virus associated gastric dysplasia: a new rare entity?
Programmed Death Ligand 1-Expressing Classical Dendritic Cells MitigateHelicobacter-Induced Gastritis.
Vaginal mucus in mice: developmental and gene expression features of epithelial mucous cells during pregnancy†.
mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways.
Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo.
Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing.
Pyloric, pseudopyloric, and spasmolytic polypeptide-expressing metaplasias in autoimmune gastritis: a case series of 22 Japanese patients.
Histological assessment of gastric pseudopyloric metaplasia: Intra- and inter-observer consistency.
A tumour-resident Lgr5(+) stem-cell-like pool drives the establishment and progression of advanced gastric cancers.
Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus.
Trefoil factor family 2 inhibits cholangiocarcinogenesis by regulating the PTEN pathway in mice.
Mast1 mediates radiation-induced gastric injury via the P38 MAPK pathway.
Histological changes associated with pyloric and pseudopyloric metaplasia after Helicobacter pylori eradication.
Evidence for heightened genetic instability in precancerous spasmolytic polypeptide expressing gastric glands.
Gastric Corpus Mucosal Hyperplasia and Neuroendocrine Cell Hyperplasia, but not Spasmolytic Polypeptide-Expressing Metaplasia, Is Prevented by a Gastrin Receptor Antagonist in H(+)/K(+)ATPase Beta Subunit Knockout Mice.
Deoxycholic acid-stimulated macrophage-derived exosomes promote spasmolytic polypeptide-expressing metaplasia in the stomach.
Early administration of dapagliflozin preserves pancreatic β-cell mass through a legacy effect in a mouse model of type 2 diabetes.
Development of solitary chemosensory cells in the distal lung after severe influenza injury.
Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer.
Activation of Signal Transduction and Activator of Transcription 3 Signaling Contributes to Helicobacter-Associated Gastric Epithelial Proliferation and Inflammation.
Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity.
Nicotine Induces Progressive Properties of Lung Adenocarcinoma A549 Cells by Inhibiting Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Expression and Plasma Membrane Localization.
A revised airway epithelial hierarchy includes CFTR-expressing ionocytes.
Depletion of club cells attenuates bleomycin-induced lung injury and fibrosis in mice.
The cytoprotective protein clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and promotes gastric cancer cell survival.
Clinical significance of spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia in Epstein-Barr virus-associated and Epstein-Barr virus-negative gastric cancer.
Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach.
Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma.
Ink4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis.
Heterogeneous Nuclear Ribonucleoprotein A1 Improves the Intestinal Injury by Regulating Apoptosis Through Trefoil Factor 2 in Mice with Anti-CD3-induced Enteritis.
Pancreatic duct glands (PDGs) are a progenitor compartment responsible for pancreatic ductal epithelial repair.
RNA sequencing of sessile serrated colon polyps identifies differentially expressed genes and immunohistochemical markers.
Promoter hypermethylation and downregulation of trefoil factor 2 in human gastric cancer.
Masumoto Y, Matsuo S, Kinjou N, Narieda Y, Wada M, Fujimoto K
Oncology letters 2024 May;27(5):212
Oncology letters 2024 May;27(5):212
Efficacy and potential therapeutic mechanism of Weiwei decoction on Spasmolytic polypeptide-expressing metaplasia in Helicobacter pylori-infected and Atp4a-knockout mice.
Hong X, Li H, Lin Y, Luo L, Xu W, Kang J, Li J, Huang B, Xu Y, Pan H, Guo S
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117062
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117062
Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids.
Bustamante-Madrid P, Barbáchano A, Albandea-Rodríguez D, Rodríguez-Cobos J, Rodríguez-Salas N, Prieto I, Burgos A, Martínez de Villarreal J, Real FX, González-Sancho JM, Larriba MJ, Lafarga M, Muñoz A, Fernández-Barral A
Cell death & disease 2024 Apr 29;15(4):301
Cell death & disease 2024 Apr 29;15(4):301
YAP targetome reveals activation of SPEM in gastric pre-neoplastic progression and regeneration.
Loe AKH, Rao-Bhatia A, Wei Z, Kim JE, Guan B, Qin Y, Hong M, Kwak HS, Liu X, Zhang L, Wrana JL, Guo H, Kim TH
Cell reports 2023 Dec 26;42(12):113497
Cell reports 2023 Dec 26;42(12):113497
A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach.
Douchi D, Yamamura A, Matsuo J, Lee JW, Nuttonmanit N, Melissa Lim YH, Suda K, Shimura M, Chen S, Pang S, Kohu K, Kaneko M, Kiyonari H, Kaneda A, Yoshida H, Taniuchi I, Osato M, Yang H, Unno M, Bok-Yan So J, Yeoh KG, Chuang LSH, Bae SC, Ito Y
Cellular and molecular gastroenterology and hepatology 2022;13(5):1317-1345
Cellular and molecular gastroenterology and hepatology 2022;13(5):1317-1345
Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium.
Higa T, Okita Y, Matsumoto A, Nakayama S, Oka T, Sugahara O, Koga D, Takeishi S, Nakatsumi H, Hosen N, Robine S, Taketo MM, Sato T, Nakayama KI
Nature communications 2022 Mar 21;13(1):1500
Nature communications 2022 Mar 21;13(1):1500
Systematic identification of cell-fate regulatory programs using a single-cell atlas of mouse development.
Fei L, Chen H, Ma L, E W, Wang R, Fang X, Zhou Z, Sun H, Wang J, Jiang M, Wang X, Yu C, Mei Y, Jia D, Zhang T, Han X, Guo G
Nature genetics 2022 Jul;54(7):1051-1061
Nature genetics 2022 Jul;54(7):1051-1061
Resolving the difference between left-sided and right-sided colorectal cancer by single-cell sequencing.
Guo W, Zhang C, Wang X, Dou D, Chen D, Li J
JCI insight 2022 Jan 11;7(1)
JCI insight 2022 Jan 11;7(1)
Glycosylation of MUC6 by α1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy.
Yuki A, Fujii C, Yamanoi K, Matoba H, Harumiya S, Kawakubo M, Nakayama J
Cancer science 2022 Feb;113(2):576-586
Cancer science 2022 Feb;113(2):576-586
Epstein-Barr virus associated gastric dysplasia: a new rare entity?
Angerilli V, Galuppini F, Pennelli G, Fanelli GN, d'Amore ESG, Michelotto M, Pilati P, Spolverato G, Pucciarelli S, Scarpa M, Farinati F, Savarino E, Realdon S, Lonardi S, Bergamo F, Loupakis F, Dei Tos AP, Vanoli A, Fassan M
Virchows Archiv : an international journal of pathology 2022 Apr;480(4):939-944
Virchows Archiv : an international journal of pathology 2022 Apr;480(4):939-944
Programmed Death Ligand 1-Expressing Classical Dendritic Cells MitigateHelicobacter-Induced Gastritis.
Go DM, Lee SH, Lee SH, Woo SH, Kim K, Kim K, Park KS, Park JH, Ha SJ, Kim WH, Choi JH, Kim DY
Cellular and molecular gastroenterology and hepatology 2021;12(2):715-739
Cellular and molecular gastroenterology and hepatology 2021;12(2):715-739
Vaginal mucus in mice: developmental and gene expression features of epithelial mucous cells during pregnancy†.
Sugiyama M, Machida N, Yasunaga A, Terai N, Fukasawa H, Ono HK, Kobayashi R, Nishiyama K, Hashimoto O, Kurusu S, Yoshioka K
Biology of reproduction 2021 Nov 15;105(5):1272-1282
Biology of reproduction 2021 Nov 15;105(5):1272-1282
mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways.
Li K, Wu H, Wang A, Charron J, Mishina Y, Habib SL, Liu H, Li B
Cell reports 2021 May 4;35(5):109069
Cell reports 2021 May 4;35(5):109069
Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo.
Little DR, Lynch AM, Yan Y, Akiyama H, Kimura S, Chen J
Nature communications 2021 May 4;12(1):2509
Nature communications 2021 May 4;12(1):2509
Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing.
Zhang M, Hu S, Min M, Ni Y, Lu Z, Sun X, Wu J, Liu B, Ying X, Liu Y
Gut 2021 Mar;70(3):464-475
Gut 2021 Mar;70(3):464-475
Pyloric, pseudopyloric, and spasmolytic polypeptide-expressing metaplasias in autoimmune gastritis: a case series of 22 Japanese patients.
Wada Y, Nakajima S, Kushima R, Takemura S, Mori N, Hasegawa H, Nakayama T, Mukaisho KI, Yoshida A, Umano S, Yamamoto K, Sugihara H, Murakami K
Virchows Archiv : an international journal of pathology 2021 Jul;479(1):169-178
Virchows Archiv : an international journal of pathology 2021 Jul;479(1):169-178
Histological assessment of gastric pseudopyloric metaplasia: Intra- and inter-observer consistency.
Rugge M, Sacchi D, Genta RM, Zanco F, Guzzinati S, Pizzi M, Fassan M, Di Sabatino A, El-Serag H
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2021 Jan;53(1):61-65
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2021 Jan;53(1):61-65
A tumour-resident Lgr5(+) stem-cell-like pool drives the establishment and progression of advanced gastric cancers.
Fatehullah A, Terakado Y, Sagiraju S, Tan TL, Sheng T, Tan SH, Murakami K, Swathi Y, Ang N, Rajarethinam R, Ming T, Tan P, Lee B, Barker N
Nature cell biology 2021 Dec;23(12):1299-1313
Nature cell biology 2021 Dec;23(12):1299-1313
Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus.
Douchi D, Yamamura A, Matsuo J, Melissa Lim YH, Nuttonmanit N, Shimura M, Suda K, Chen S, Pang S, Kohu K, Abe T, Shioi G, Kim G, Shabbir A, Srivastava S, Unno M, Bok-Yan So J, Teh M, Yeoh KG, Chuang LSH, Ito Y
Gastroenterology 2021 Dec;161(6):1907-1923.e26
Gastroenterology 2021 Dec;161(6):1907-1923.e26
Trefoil factor family 2 inhibits cholangiocarcinogenesis by regulating the PTEN pathway in mice.
Hasebe K, Yamaguchi J, Kokuryo T, Yokoyama Y, Ochiai Y, Nagino M, Ebata T
Carcinogenesis 2021 Dec 31;42(12):1496-1505
Carcinogenesis 2021 Dec 31;42(12):1496-1505
Mast1 mediates radiation-induced gastric injury via the P38 MAPK pathway.
Ding W, Lu Y, Zhou A, Chen Y, Wang Z, Wang L, Tian Y
Experimental cell research 2021 Dec 15;409(2):112913
Experimental cell research 2021 Dec 15;409(2):112913
Histological changes associated with pyloric and pseudopyloric metaplasia after Helicobacter pylori eradication.
Wada Y, Kushima R, Kodama M, Fukuda M, Fukuda K, Okamoto K, Ogawa R, Mizukami K, Okimoto T, Murakami K
Virchows Archiv : an international journal of pathology 2020 Oct;477(4):489-496
Virchows Archiv : an international journal of pathology 2020 Oct;477(4):489-496
Evidence for heightened genetic instability in precancerous spasmolytic polypeptide expressing gastric glands.
Chen J, Zhu C, Wang C, Hu C, Czajkowsky DM, Guo Y, Liu B, Shao Z
Journal of medical genetics 2020 Jun;57(6):385-388
Journal of medical genetics 2020 Jun;57(6):385-388
Gastric Corpus Mucosal Hyperplasia and Neuroendocrine Cell Hyperplasia, but not Spasmolytic Polypeptide-Expressing Metaplasia, Is Prevented by a Gastrin Receptor Antagonist in H(+)/K(+)ATPase Beta Subunit Knockout Mice.
Aasarød KM, Waldum HL, Stunes AK, Sandvik AK, Flatberg A, Mjønes P, Syversen U, Bakke I, Fossmark R
International journal of molecular sciences 2020 Jan 31;21(3)
International journal of molecular sciences 2020 Jan 31;21(3)
Deoxycholic acid-stimulated macrophage-derived exosomes promote spasmolytic polypeptide-expressing metaplasia in the stomach.
Xu X, Cheng J, Luo S, Gong X, Huang D, Xu J, Qian Y, Wan X, Zhou H
Biochemical and biophysical research communications 2020 Apr 9;524(3):649-655
Biochemical and biophysical research communications 2020 Apr 9;524(3):649-655
Early administration of dapagliflozin preserves pancreatic β-cell mass through a legacy effect in a mouse model of type 2 diabetes.
Kanno A, Asahara SI, Kawamura M, Furubayashi A, Tsuchiya S, Suzuki E, Takai T, Koyanagi-Kimura M, Matsuda T, Okada Y, Ogawa W, Kido Y
Journal of diabetes investigation 2019 May;10(3):577-590
Journal of diabetes investigation 2019 May;10(3):577-590
Development of solitary chemosensory cells in the distal lung after severe influenza injury.
Rane CK, Jackson SR, Pastore CF, Zhao G, Weiner AI, Patel NN, Herbert DR, Cohen NA, Vaughan AE
American journal of physiology. Lung cellular and molecular physiology 2019 Jun 1;316(6):L1141-L1149
American journal of physiology. Lung cellular and molecular physiology 2019 Jun 1;316(6):L1141-L1149
Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer.
Jahan R, Ganguly K, Smith LM, Atri P, Carmicheal J, Sheinin Y, Rachagani S, Natarajan G, Brand RE, Macha MA, Grandgenett PM, Kaur S, Batra SK
EBioMedicine 2019 Apr;42:375-385
EBioMedicine 2019 Apr;42:375-385
Activation of Signal Transduction and Activator of Transcription 3 Signaling Contributes to Helicobacter-Associated Gastric Epithelial Proliferation and Inflammation.
Ishii Y, Shibata W, Sugimori M, Kaneta Y, Kanno M, Sato T, Sue S, Kameta E, Kaneko H, Irie K, Sasaki T, Kondo M, Maeda S
Gastroenterology research and practice 2018;2018:9050715
Gastroenterology research and practice 2018;2018:9050715
Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity.
Tata PR, Chow RD, Saladi SV, Tata A, Konkimalla A, Bara A, Montoro D, Hariri LP, Shih AR, Mino-Kenudson M, Mou H, Kimura S, Ellisen LW, Rajagopal J
Developmental cell 2018 Mar 26;44(6):679-693.e5
Developmental cell 2018 Mar 26;44(6):679-693.e5
Nicotine Induces Progressive Properties of Lung Adenocarcinoma A549 Cells by Inhibiting Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Expression and Plasma Membrane Localization.
Li H, Ma N, Wang J, Wang Y, Yuan C, Wu J, Luo M, Yang J, Chen J, Shi J, Liu X
Technology in cancer research & treatment 2018 Jan 1;17:1533033818809984
Technology in cancer research & treatment 2018 Jan 1;17:1533033818809984
A revised airway epithelial hierarchy includes CFTR-expressing ionocytes.
Montoro DT, Haber AL, Biton M, Vinarsky V, Lin B, Birket SE, Yuan F, Chen S, Leung HM, Villoria J, Rogel N, Burgin G, Tsankov AM, Waghray A, Slyper M, Waldman J, Nguyen L, Dionne D, Rozenblatt-Rosen O, Tata PR, Mou H, Shivaraju M, Bihler H, Mense M, Tearney GJ, Rowe SM, Engelhardt JF, Regev A, Rajagopal J
Nature 2018 Aug;560(7718):319-324
Nature 2018 Aug;560(7718):319-324
Depletion of club cells attenuates bleomycin-induced lung injury and fibrosis in mice.
Yokoyama T, Yanagihara T, Suzuki K, Hamada N, Tsubouchi K, Ogata-Suetsugu S, Mikumo H, Ikeda-Harada C, Maeyama T, Kuwano K, Nakanishi Y
Journal of inflammation (London, England) 2017;14:20
Journal of inflammation (London, England) 2017;14:20
The cytoprotective protein clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and promotes gastric cancer cell survival.
Vange P, Bruland T, Doseth B, Fossmark R, Sousa MML, Beisvag V, Sørdal Ø, Qvigstad G, Waldum HL, Sandvik AK, Bakke I
PloS one 2017;12(9):e0184514
PloS one 2017;12(9):e0184514
Clinical significance of spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia in Epstein-Barr virus-associated and Epstein-Barr virus-negative gastric cancer.
Zhang Y, Chen JN, Dong M, Zhang ZG, Zhang YW, Wu JY, Du H, Li HG, Huang Y, Shao CK
Human pathology 2017 May;63:128-138
Human pathology 2017 May;63:128-138
Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach.
Leushacke M, Tan SH, Wong A, Swathi Y, Hajamohideen A, Tan LT, Goh J, Wong E, Denil SLIJ, Murakami K, Barker N
Nature cell biology 2017 Jul;19(7):774-786
Nature cell biology 2017 Jul;19(7):774-786
Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma.
Schellnegger R, Quante A, Rospleszcz S, Schernhammer M, Höhl B, Tobiasch M, Pastula A, Brandtner A, Abrams JA, Strauch K, Schmid RM, Vieth M, Wang TC, Quante M
Cancer prevention research (Philadelphia, Pa.) 2017 Jan;10(1):55-66
Cancer prevention research (Philadelphia, Pa.) 2017 Jan;10(1):55-66
Ink4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis.
Seishima R, Wada T, Tsuchihashi K, Okazaki S, Yoshikawa M, Oshima H, Oshima M, Sato T, Hasegawa H, Kitagawa Y, Goldenring JR, Saya H, Nagano O
Cancer prevention research (Philadelphia, Pa.) 2015 Jun;8(6):492-501
Cancer prevention research (Philadelphia, Pa.) 2015 Jun;8(6):492-501
Heterogeneous Nuclear Ribonucleoprotein A1 Improves the Intestinal Injury by Regulating Apoptosis Through Trefoil Factor 2 in Mice with Anti-CD3-induced Enteritis.
Ando K, Fujiya M, Konishi H, Ueno N, Inaba Y, Moriichi K, Ikuta K, Tanabe H, Ohtake T, Kohgo Y
Inflammatory bowel diseases 2015 Jul;21(7):1541-52
Inflammatory bowel diseases 2015 Jul;21(7):1541-52
Pancreatic duct glands (PDGs) are a progenitor compartment responsible for pancreatic ductal epithelial repair.
Yamaguchi J, Liss AS, Sontheimer A, Mino-Kenudson M, Castillo CF, Warshaw AL, Thayer SP
Stem cell research 2015 Jul;15(1):190-202
Stem cell research 2015 Jul;15(1):190-202
RNA sequencing of sessile serrated colon polyps identifies differentially expressed genes and immunohistochemical markers.
Delker DA, McGettigan BM, Kanth P, Pop S, Neklason DW, Bronner MP, Burt RW, Hagedorn CH
PloS one 2014;9(2):e88367
PloS one 2014;9(2):e88367
Promoter hypermethylation and downregulation of trefoil factor 2 in human gastric cancer.
Jiang P, Yu G, Zhang Y, Xiang Y, Zhu Z, Feng W, Lee W, Zhang Y
Oncology letters 2014 May;7(5):1525-1531
Oncology letters 2014 May;7(5):1525-1531
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human stomach tissue were subjected to SDS PAGE followed by western blot with 13681-1-AP(TFF2 antibody) at dilution of 1:100
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human stomach cancer using 13681-1-AP(TFF2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TFF2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TFF2. This antibody recognizes human,mouse,rat antigen. The TFF2 antibody has been validated for the following applications: ELISA, IHC, WB analysis.