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Learn15052-1-AP
antibody from Proteintech Group
Targeting: SMOX
C20orf16, dJ779E11.1, FLJ20746, MGC1010, PAO, PAOh1, SMO
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [19]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [2]
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- Product number
- 15052-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15052-1-AP, RRID:AB_2239689
- Product name
- SMOX antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SMOX antibody (Cat. #15052-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A Novel Integrated Metabolism-Immunity Gene Expression Model Predicts the Prognosis of Lung Adenocarcinoma Patients.
The regulation of polyamine pathway proteins in models of skeletal muscle hypertrophy and atrophy: a potential role for mTORC1.
SMOX expression predicts the prognosis of non-small cell lung cancer.
Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver.
The Polyamine Putrescine Promotes Human Epidermal Melanogenesis.
Regulation of Spermine Oxidase through Hypoxia-Inducible Factor-1α Signaling in Retinal Glial Cells under Hypoxic Conditions.
Pharmacological Inhibition of Spermine Oxidase Reduces Neurodegeneration and Improves Retinal Function in Diabetic Mice.
Silencing of circular RNA HIPK2 in neural stem cells enhances functional recovery following ischaemic stroke.
Proteomic analysis revealed different responses to hypergravity of soleus and extensor digitorum longus muscles in mice.
Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response.
Targeting Smox Is Neuroprotective and Ameliorates Brain Inflammation in Cerebral Ischemia/Reperfusion Rats.
Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes.
Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma.
Spermine oxidase promotes bile canalicular lumen formation through acrolein production.
Adaptive responses of heart and skeletal muscle to spermine oxidase overexpression: Evaluation of a new transgenic mouse model.
Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy.
Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy.
A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury.
Chen S, Duan Y, Wu Y, Yang D, An J
Frontiers in pharmacology 2021;12:728368
Frontiers in pharmacology 2021;12:728368
The regulation of polyamine pathway proteins in models of skeletal muscle hypertrophy and atrophy: a potential role for mTORC1.
Tabbaa M, Ruz Gomez T, Campelj DG, Gregorevic P, Hayes A, Goodman CA
American journal of physiology. Cell physiology 2021 Jun 1;320(6):C987-C999
American journal of physiology. Cell physiology 2021 Jun 1;320(6):C987-C999
SMOX expression predicts the prognosis of non-small cell lung cancer.
Huang Z, Wang S, Zhang HJ, Zhou YL, Shi JH
Annals of translational medicine 2021 Jul;9(13):1048
Annals of translational medicine 2021 Jul;9(13):1048
Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
Sandusky-Beltran LA, Kovalenko A, Placides DS, Ratnasamy K, Ma C, Hunt JB Jr, Liang H, Calahatian JIT, Michalski C, Fahnestock M, Blair LJ, Darling AL, Baker JD, Fontaine SN, Dickey CA, Gamsby JJ, Nash KR, Abner E, Selenica MB, Lee DC
The Journal of clinical investigation 2021 Feb 15;131(4)
The Journal of clinical investigation 2021 Feb 15;131(4)
Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver.
Uemura T, Akasaka Y, Ikegaya H
Heliyon 2020 Sep;6(9):e05031
Heliyon 2020 Sep;6(9):e05031
The Polyamine Putrescine Promotes Human Epidermal Melanogenesis.
Sridharan A, Shi M, Leo VI, Subramaniam N, Lim TC, Uemura T, Igarashi K, Tien Guan ST, Tan NS, Vardy LA
The Journal of investigative dermatology 2020 Oct;140(10):2032-2040.e1
The Journal of investigative dermatology 2020 Oct;140(10):2032-2040.e1
Regulation of Spermine Oxidase through Hypoxia-Inducible Factor-1α Signaling in Retinal Glial Cells under Hypoxic Conditions.
Wu D, Noda K, Murata M, Liu Y, Kanda A, Ishida S
Investigative ophthalmology & visual science 2020 Jun 3;61(6):52
Investigative ophthalmology & visual science 2020 Jun 3;61(6):52
Pharmacological Inhibition of Spermine Oxidase Reduces Neurodegeneration and Improves Retinal Function in Diabetic Mice.
Liu F, Saul AB, Pichavaram P, Xu Z, Rudraraju M, Somanath PR, Smith SB, Caldwell RB, Narayanan SP
Journal of clinical medicine 2020 Jan 25;9(2)
Journal of clinical medicine 2020 Jan 25;9(2)
Silencing of circular RNA HIPK2 in neural stem cells enhances functional recovery following ischaemic stroke.
Wang G, Han B, Shen L, Wu S, Yang L, Liao J, Wu F, Li M, Leng S, Zang F, Zhang Y, Bai Y, Mao Y, Chen B, Yao H
EBioMedicine 2020 Feb;52:102660
EBioMedicine 2020 Feb;52:102660
Proteomic analysis revealed different responses to hypergravity of soleus and extensor digitorum longus muscles in mice.
Ohira T, Ino Y, Nakai Y, Morita H, Kimura A, Kurata Y, Kagawa H, Kimura M, Egashira K, Moriya S, Hiramatsu K, Kawakita M, Kimura Y, Hirano H
Journal of proteomics 2020 Apr 15;217:103686
Journal of proteomics 2020 Apr 15;217:103686
Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response.
Sandusky-Beltran LA, Kovalenko A, Ma C, Calahatian JIT, Placides DS, Watler MD, Hunt JB, Darling AL, Baker JD, Blair LJ, Martin MD, Fontaine SN, Dickey CA, Lussier AL, Weeber EJ, Selenica MB, Nash KR, Gordon MN, Morgan D, Lee DC
Alzheimer's research & therapy 2019 Jun 29;11(1):58
Alzheimer's research & therapy 2019 Jun 29;11(1):58
Targeting Smox Is Neuroprotective and Ameliorates Brain Inflammation in Cerebral Ischemia/Reperfusion Rats.
Fan J, Chen M, Wang X, Tian Z, Wang J, Fan D, Zeng J, Zhang K, Dai X
Toxicological sciences : an official journal of the Society of Toxicology 2019 Apr 1;168(2):381-393
Toxicological sciences : an official journal of the Society of Toxicology 2019 Apr 1;168(2):381-393
Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes.
Lane DJR, Bae DH, Siafakas AR, Suryo Rahmanto Y, Al-Akra L, Jansson PJ, Casero RA Jr, Richardson DR
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):2793-2813
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):2793-2813
Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma.
Bianchi-Smiraglia A, Bagati A, Fink EE, Affronti HC, Lipchick BC, Moparthy S, Long MD, Rosario SR, Lightman SM, Moparthy K, Wolff DW, Yun DH, Han Z, Polechetti A, Roll MV, Gitlin II, Leonova KI, Rowsam AM, Kandel ES, Gudkov AV, Bergsagel PL, Lee KP, Smiraglia DJ, Nikiforov MA
The Journal of clinical investigation 2018 Oct 1;128(10):4682-4696
The Journal of clinical investigation 2018 Oct 1;128(10):4682-4696
Spermine oxidase promotes bile canalicular lumen formation through acrolein production.
Uemura T, Takasaka T, Igarashi K, Ikegaya H
Scientific reports 2017 Nov 1;7(1):14841
Scientific reports 2017 Nov 1;7(1):14841
Adaptive responses of heart and skeletal muscle to spermine oxidase overexpression: Evaluation of a new transgenic mouse model.
Ceci R, Duranti G, Leonetti A, Pietropaoli S, Spinozzi F, Marcocci L, Amendola R, Cecconi F, Sabatini S, Mariottini P, Cervelli M
Free radical biology & medicine 2017 Feb;103:216-225
Free radical biology & medicine 2017 Feb;103:216-225
Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy.
Patel C, Xu Z, Shosha E, Xing J, Lucas R, Caldwell RW, Caldwell RB, Narayanan SP
Biochimica et biophysica acta 2016 Sep;1862(9):1628-39
Biochimica et biophysica acta 2016 Sep;1862(9):1628-39
Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy.
Bongers KS, Fox DK, Kunkel SD, Stebounova LV, Murry DJ, Pufall MA, Ebert SM, Dyle MC, Bullard SA, Dierdorff JM, Adams CM
American journal of physiology. Endocrinology and metabolism 2015 Jan 15;308(2):E144-58
American journal of physiology. Endocrinology and metabolism 2015 Jan 15;308(2):E144-58
A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury.
Cervelli M, Bellavia G, D'Amelio M, Cavallucci V, Moreno S, Berger J, Nardacci R, Marcoli M, Maura G, Piacentini M, Amendola R, Cecconi F, Mariottini P
PloS one 2013;8(6):e64810
PloS one 2013;8(6):e64810
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-13 cells were subjected to SDS PAGE followed by western blot with 15052-1-AP(SMOX antibody) at dilution of 1:500
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 15052-1-AP( SMOX Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 15052-1-AP(SMOX antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SMOX antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SMOX. This antibody recognizes human,mouse,rat antigen. The SMOX antibody has been validated for the following applications: ELISA, WB, IHC analysis.
