15052-1-AP

antibody from Proteintech Group

Targeting: SMOX C20orf16, dJ779E11.1, FLJ20746, MGC1010, PAO, PAOh1, SMO

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

15052-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#15052-1-AP, RRID:AB_2239689

Product name

SMOX antibody

Antibody type

Polyclonal

Description

KD/KO validated SMOX antibody (Cat. #15052-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Polyamine-dependent metabolic shielding regulates alternative splicing.

Zabala-Letona A, Pujana-Vaquerizo M, Martinez-Laosa B, Ponce-Rodriguez M, Garcia-Longarte S, Mendizabal I, Gimeno A, Rogalska M, Tan J, Cabrera D, van Liempd S, Ximenez-Embun P, Espinosa S, Fagoaga-Eugui M, Peccati F, Zakrzewski M, Astobiza I, Arana-Castañares M, Cherkaoui S, Sendino M, Martín-Barros I, Ercilla A, Bozal-Basterra L, Carlevaris O, Arruabarrena-Aristorena A, Pérez-Andrés E, Santamaría-Zamorano T, Ferrer-Bonsoms JA, Carazo F, Cieśla M, Lobato C, Seoane J, Martín-Martín N, Barrio R, Sutherland JD, Aransay AM, Falcón-Pérez JM, Martínez-Pastor B, Rubio A, Blanco FJ, Hogarty MD, Morscher RJ, Berra E, Serwa RA, Jiménez-Barbero J, Jiménez-Osés G, Efeyan A, Finley L, Lizcano JM, Muñoz J, Valcarcel J, Carracedo A
Nature 2026 Mar;651(8106):819-828

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Effects of spermine on osteoblasts during iron deficiency in vitro and in vivo during chronic kidney disease.

Miller C, Segvich DM, Wanner J, Mahmood H, Kirschner KM, Matz JA, Santangelo S, Wallace JM, Clinkenbeard EL
Bone 2026 Jul;208:117867

---

Spermine Oxidase Serves as a Key Functional Node in Microbial Dysbiosis-Induced Breast Carcinogenesis.

Nandi D, Parida S, Verma D, Foley JR, Stewart TM, Korangath P, Thatikonda S, Siddharth S, Wu Q, Yi M, Bishai W, Ivkov R, Sears CL, Casero RA Jr, Sharma D
Cancer research 2026 Apr 15;86(8):1920-1938

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Assessing the Role of Polyamine Metabolites in Blood and the DNA Methylation of Mycobacterium Tuberculosis in Patients with Multidrug-Resistant Tuberculosis.

Yan L, Niu X, Liang K, Guan F, Yu X, Ye Z, Huang M, Liang H, Zhong X, Zeng J
International journal of medical sciences 2025;22(8):1762-1772

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Tellimagrandin II Stimulates Inflammasomes by Causing an Accumulation of 3-Aminopropanal, Which Promotes Apoptosis of Endometriotic Cells While Inhibiting Invasion.

Fan W, Zhang Y, Zhao R
Journal of inflammation research 2025;18:18181-18192

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Multi-omics analysis of polyamine metabolism implicates NT5E/CD73 in the progression of pancreatic cancer.

Zhang E, Ding X, Zhang J, Liu W, Liu G, Li M, Liu X, Wang Y, Zhang F, Li B, Zhu Y, Yan Y, Liu J, Wang Y, Tian X, Ma Y, Yang Y
Cancer letters 2025 Oct 10;630:217887

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Calcium Fructoborate Improves Knee Osteoarthritis in Rats by Activating Hedgehog Signaling Through DDIT3.

Yan T, Wang P, Cao Z
Biological trace element research 2025 Jul;203(7):3803-3819

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NF-E2-related factor 1 suppresses the expression of a spermine oxidase and the production of highly reactive acrolein.

Hirakawa T, Taniuchi M, Iguchi Y, Bogahawaththa S, Yoshitake K, Werellagama S, Uemura T, Tsujita T
Scientific reports 2025 Apr 21;15(1):12405

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Natural Product Quercetin-3-methyl ether Promotes Colorectal Cancer Cell Apoptosis by Downregulating Intracellular Polyamine Signaling.

Zeng J, Zhang Y, Fang Y, Lian J, Zhang H, Zhang S, Lin B, Ye Z, Li C, Qiu X, Liang Y
International journal of medical sciences 2024;21(5):904-913

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Inhibitory Effect of Lactobacillus Paracasei CMU-Pb-L5 In a Subcutaneous Transplanted Tumor Model of Colorectal Cancer.

Chang X, Zhang S, Li C, Zhang H, Yang W, Zhang W, Ye Z, Liang Y, Qiu X, Zeng J
International journal of medical sciences 2024;21(13):2525-2536

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Potential Association of Gut Microbial Metabolism and Circulating mRNA Based on Multiomics Sequencing Analysis in Fetal Growth Restriction.

Tang H, Li D, Peng J, Yang W, Zhang X, Li H
Mediators of inflammation 2024;2024:9986187

---

Prognostic Signature in Osteosarcoma Based on Amino Acid Metabolism-Associated Genes.

Feng L, Chen Y, Mei X, Wang L, Zhao W, Yao J
Cancer biotherapy & radiopharmaceuticals 2024 Sep;39(7):517-531

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Polyamine Catabolism and Its Role in Renal Injury and Fibrosis in Mice Subjected to Repeated Low-Dose Cisplatin Treatment.

Zahedi K, Barone S, Brooks M, Stewart TM, Foley JR, Nwafor A, Casero RA Jr, Soleimani M
Biomedicines 2024 Mar 13;12(3)

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Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke.

Wang G, Li Z, Lin P, Zhang H, Wang Y, Zhang T, Wang H, Li H, Lin L, Zhao Y, Jia L, Chen Y, Ji H, Zhao W, Fu Z, Zhong Z
International immunopharmacology 2024 Jan 5;126:111183

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Identifying polyamine related biomarkers in diagnosis and treatment of ulcerative colitis by integrating bulk and single-cell sequencing data.

Wei W, Lu Y, Zhang M, Guo J, Zhang H
Scientific reports 2024 Aug 5;14(1):18094

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Autophagy-enabled protein degradation: Key to platelet activation and ANGII production in patients with type 2 diabetes mellitus.

Wu Q, Yu S, Zang S, Peng K, Wang Z
Heliyon 2024 Aug 30;10(16):e36131

---

P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance.

Jiang X, Baig AH, Palazzo G, Del Pizzo R, Bortecen T, Groessl S, Zaal EA, Amaya Ramirez CC, Kowar A, Aviles-Huerta D, Berkers CR, Palm W, Tschaharganeh D, Krijgsveld J, Loayza-Puch F
Nature communications 2024 Aug 28;15(1):7458

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Spermidine from arginine metabolism activates Nrf2 and inhibits kidney fibrosis.

Aihara S, Torisu K, Uchida Y, Imazu N, Nakano T, Kitazono T
Communications biology 2023 Jun 28;6(1):676

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The upregulation of peripheral blood polyamine metabolites spermidine and spermine in children with hand, foot, mouth disease is related to enterovirus 71 capsid protein VP1, but not VP4.

Li C, Zhang W, Chang X, Di X, Xie Q, Lin B, Zhang H, Ye Z, Lan M, Lian J, Zhang H, Qiu X, Zeng J, Huang M
Translational pediatrics 2023 Feb 28;12(2):194-207

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Inhibition of Polyamine Catabolism Reduces Cellular Senescence.

Uemura T, Matsunaga M, Yokota Y, Takao K, Furuchi T
International journal of molecular sciences 2023 Aug 29;24(17)

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Identification of the effect and mechanism of Yiyi Fuzi Baijiang powder against colorectal cancer using network pharmacology and experimental validation.

Xiang B, Geng R, Zhang Z, Ji X, Zou J, Chen L, Liu J
Frontiers in pharmacology 2022;13:929836

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Progesterone and interferon tau regulate expression of polyamine enzymes during the ovine peri-implantation period†.

Halloran KM, Stenhouse C, Moses RM, Seo H, Johnson GA, Wu G, Bazer FW
Biology of reproduction 2022 May 17;106(5):865-878

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Expression of Spermine Oxidase Is Associated with Colorectal Carcinogenesis and Prognosis of Patients.

Kim S, Kim D, Roh S, Hong I, Kim H, Ahn TS, Kang DH, Lee MS, Baek MJ, Kwak HJ, Kim CJ, Jeong D
Biomedicines 2022 Mar 8;10(3)

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Treatment with MDL 72527 Ameliorated Clinical Symptoms, Retinal Ganglion Cell Loss, Optic Nerve Inflammation, and Improved Visual Acuity in an Experimental Model of Multiple Sclerosis.

Liu F, Alfarhan M, Baker L, Shenoy N, Liao Y, Henry-Ojo HO, Somanath PR, Narayanan SP
Cells 2022 Dec 16;11(24)

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A Novel Integrated Metabolism-Immunity Gene Expression Model Predicts the Prognosis of Lung Adenocarcinoma Patients.

Chen S, Duan Y, Wu Y, Yang D, An J
Frontiers in pharmacology 2021;12:728368

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The regulation of polyamine pathway proteins in models of skeletal muscle hypertrophy and atrophy: a potential role for mTORC1.

Tabbaa M, Ruz Gomez T, Campelj DG, Gregorevic P, Hayes A, Goodman CA
American journal of physiology. Cell physiology 2021 Jun 1;320(6):C987-C999

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SMOX expression predicts the prognosis of non-small cell lung cancer.

Huang Z, Wang S, Zhang HJ, Zhou YL, Shi JH
Annals of translational medicine 2021 Jul;9(13):1048

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Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.

Sandusky-Beltran LA, Kovalenko A, Placides DS, Ratnasamy K, Ma C, Hunt JB Jr, Liang H, Calahatian JIT, Michalski C, Fahnestock M, Blair LJ, Darling AL, Baker JD, Fontaine SN, Dickey CA, Gamsby JJ, Nash KR, Abner E, Selenica MB, Lee DC
The Journal of clinical investigation 2021 Feb 15;131(4)

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Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver.

Uemura T, Akasaka Y, Ikegaya H
Heliyon 2020 Sep;6(9):e05031

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The Polyamine Putrescine Promotes Human Epidermal Melanogenesis.

Sridharan A, Shi M, Leo VI, Subramaniam N, Lim TC, Uemura T, Igarashi K, Tien Guan ST, Tan NS, Vardy LA
The Journal of investigative dermatology 2020 Oct;140(10):2032-2040.e1

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Regulation of Spermine Oxidase through Hypoxia-Inducible Factor-1α Signaling in Retinal Glial Cells under Hypoxic Conditions.

Wu D, Noda K, Murata M, Liu Y, Kanda A, Ishida S
Investigative ophthalmology & visual science 2020 Jun 3;61(6):52

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Pharmacological Inhibition of Spermine Oxidase Reduces Neurodegeneration and Improves Retinal Function in Diabetic Mice.

Liu F, Saul AB, Pichavaram P, Xu Z, Rudraraju M, Somanath PR, Smith SB, Caldwell RB, Narayanan SP
Journal of clinical medicine 2020 Jan 25;9(2)

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Silencing of circular RNA HIPK2 in neural stem cells enhances functional recovery following ischaemic stroke.

Wang G, Han B, Shen L, Wu S, Yang L, Liao J, Wu F, Li M, Leng S, Zang F, Zhang Y, Bai Y, Mao Y, Chen B, Yao H
EBioMedicine 2020 Feb;52:102660

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Proteomic analysis revealed different responses to hypergravity of soleus and extensor digitorum longus muscles in mice.

Ohira T, Ino Y, Nakai Y, Morita H, Kimura A, Kurata Y, Kagawa H, Kimura M, Egashira K, Moriya S, Hiramatsu K, Kawakita M, Kimura Y, Hirano H
Journal of proteomics 2020 Apr 15;217:103686

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Chemoprobe-based assays of histone lysine demethylase 1A target occupation enable in vivo pharmacokinetics and pharmacodynamics studies of KDM1A inhibitors.

Mascaró C, Ortega A, Carceller E, Ruiz Rodriguez R, Ciceri F, Lunardi S, Yu L, Hilbert M, Maes T
The Journal of biological chemistry 2019 May 17;294(20):8311-8322

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Spermidine/spermine-N(1)-acetyltransferase ablation impacts tauopathy-induced polyamine stress response.

Sandusky-Beltran LA, Kovalenko A, Ma C, Calahatian JIT, Placides DS, Watler MD, Hunt JB, Darling AL, Baker JD, Blair LJ, Martin MD, Fontaine SN, Dickey CA, Lussier AL, Weeber EJ, Selenica MB, Nash KR, Gordon MN, Morgan D, Lee DC
Alzheimer's research & therapy 2019 Jun 29;11(1):58

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Targeting Smox Is Neuroprotective and Ameliorates Brain Inflammation in Cerebral Ischemia/Reperfusion Rats.

Fan J, Chen M, Wang X, Tian Z, Wang J, Fan D, Zeng J, Zhang K, Dai X
Toxicological sciences : an official journal of the Society of Toxicology 2019 Apr 1;168(2):381-393

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Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes.

Lane DJR, Bae DH, Siafakas AR, Suryo Rahmanto Y, Al-Akra L, Jansson PJ, Casero RA Jr, Richardson DR
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):2793-2813

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Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma.

Bianchi-Smiraglia A, Bagati A, Fink EE, Affronti HC, Lipchick BC, Moparthy S, Long MD, Rosario SR, Lightman SM, Moparthy K, Wolff DW, Yun DH, Han Z, Polechetti A, Roll MV, Gitlin II, Leonova KI, Rowsam AM, Kandel ES, Gudkov AV, Bergsagel PL, Lee KP, Smiraglia DJ, Nikiforov MA
The Journal of clinical investigation 2018 Oct 1;128(10):4682-4696

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Spermine oxidase promotes bile canalicular lumen formation through acrolein production.

Uemura T, Takasaka T, Igarashi K, Ikegaya H
Scientific reports 2017 Nov 1;7(1):14841

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Adaptive responses of heart and skeletal muscle to spermine oxidase overexpression: Evaluation of a new transgenic mouse model.

Ceci R, Duranti G, Leonetti A, Pietropaoli S, Spinozzi F, Marcocci L, Amendola R, Cecconi F, Sabatini S, Mariottini P, Cervelli M
Free radical biology & medicine 2017 Feb;103:216-225

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Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy.

Patel C, Xu Z, Shosha E, Xing J, Lucas R, Caldwell RW, Caldwell RB, Narayanan SP
Biochimica et biophysica acta 2016 Sep;1862(9):1628-39

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Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy.

Bongers KS, Fox DK, Kunkel SD, Stebounova LV, Murry DJ, Pufall MA, Ebert SM, Dyle MC, Bullard SA, Dierdorff JM, Adams CM
American journal of physiology. Endocrinology and metabolism 2015 Jan 15;308(2):E144-58

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A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury.

Cervelli M, Bellavia G, D'Amelio M, Cavallucci V, Moreno S, Berger J, Nardacci R, Marcoli M, Maura G, Piacentini M, Amendola R, Cecconi F, Mariottini P
PloS one 2013;8(6):e64810

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

PC-13 cells were subjected to SDS PAGE followed by western blot with 15052-1-AP(SMOX antibody) at dilution of 1:500

Sample type

cell line

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 15052-1-AP( SMOX Antibody) at dilution of 1:1000

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human gliomas using 15052-1-AP(SMOX antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The SMOX antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SMOX. This antibody recognizes human,mouse,rat antigen. The SMOX antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

15052-1-AP.pdf

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