ADAM32

This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. This gene is predominantly expressed in the testis. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Description

ADAM metallopeptidase domain 32

Tissue specificity

Tissue enriched (testis)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

8 (39106990 - 39284917)

Ensembl ID

ENSG00000197140  (ver. 103.38)

Orthologs

Mouse Adam32: ENSMUSG00000037437

UniProt

Q8TC27

neXtProt

NX_Q8TC27

Human splice variants
Mouse splice variants

Protein structure