MTARC2

The protein encoded by this gene is an enzyme found in the outer mitochondrial membrane that reduces N-hydroxylated substrates. The encoded protein uses molybdenum as a cofactor and cytochrome b5 type B and NADH cytochrome b5 reductase as accessory proteins. One type of substrate used is N-hydroxylated nucleotide base analogues, which can be toxic to a cell. Other substrates include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs, which are activated by the encoded enzyme. Multiple transcript variants encoding the different isoforms have been found for this gene. [provided by RefSeq, Sep 2016]

Description

Mitochondrial amidoxime reducing component 2

Tissue specificity

Tissue enhanced (kidney, liver)

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (220748225 - 220784815)

Ensembl ID

ENSG00000117791  (ver. 103.38)

Orthologs

Mouse Mtarc2: ENSMUSG00000073481

UniProt

Q969Z3

neXtProt

NX_Q969Z3

Human splice variants
Mouse splice variants

Protein structure