MGST1

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]

Description

Microsomal glutathione S-transferase 1

Tissue specificity

Tissue enhanced (adipose tissue, adrenal gland, liver)

Subcell location

Endoplasmic reticulum, Mitochondria

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (16347142 - 16609259)

Ensembl ID

ENSG00000008394  (ver. 103.38)

Orthologs

Mouse Mgst1: ENSMUSG00000008540

UniProt

P10620

neXtProt

NX_P10620

Human splice variants
Mouse splice variants

Protein structure