14651-1-AP

antibody from Proteintech Group

Targeting: TMPO LAP2, LEMD4, TP

Provider product page for 14651-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [14]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 14651-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14651-1-AP, RRID:AB_2205440
Product name: TMPO/LAP2 antibody
Antibody type: Polyclonal
Description: KD/KO validated TMPO/LAP2 antibody (Cat. #14651-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TMPO protein structure - 14651-1-AP shown in red.

Submitted references LAP2 Isoform Profile in Heart Ageing and in Cardiac Cell Proliferation and Differentiation: Input From CRISPR-Cas9-mediated LAP2a Knockdown in H9C2.

Vadrot N, Moulin M, Ferreiro A, Richard P, Buendia B
International journal of medical sciences 2026;23(3):741-757

LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis.

Lewis R, Sinigiani V, Maziak N, Koos K, Bersaglieri C, Zemp I, Ashiono C, Ciaudo C, Horvath P, Vaquerizas JM, Santoro R, Sharma P, Kutay U
Nature cell biology 2026 Mar;28(3):536-552

Nuclear N-glycosylation maintains H3K9me3 heterochromatin and genomic stability.

Tang X, Dai R, Qing L, Zhang Z, Li H, Lu L, Lin H, Ji D, Dan W, He Y, Liu X, Yang T, Chang W, Mao Y, Sun S, Ding J
Nature cell biology 2026 Apr 28;

IFNα2b/5-FU inhibits proliferation and cell cycle of squamous carcinoma cell line Cal27.

Wu ZB, Wang GY, Wang B, Peng X, Wang JS, Zhang MC, Geng W, Xie HT
International journal of ophthalmology 2025;18(4):565-574

ZBP1 senses splicing aberration through Z-RNA to promote cell death.

Yang ZH, Wu P, Zhang BX, Yang CR, Huang J, Wu L, Guo SH, Zhou Y, Mao Y, Yin Y, Wu X, Cheng P, Li B, Zhou R, Shen HM, Nie S, Cai ZY, Mo W
Molecular cell 2025 May 1;85(9):1775-1789.e5

c-Fos regulated by TMPO/ERK axis promotes 5-FU resistance via inducing NANOG transcription in colon cancer.

Gui Y, Qian X, Ding Y, Chen Q, Fangyu Ye, Ye Y, Hou Y, Yu J, Zhao L
Cell death & disease 2024 Jan 17;15(1):61

Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1.

Yang Y, Zhang J, Lv M, Cui N, Shan B, Sun Q, Yan L, Zhang M, Zou C, Yuan J, Xu D
Nature cell biology 2024 Apr;26(4):567-580

DENND2B activates Rab35 at the intercellular bridge, regulating cytokinetic abscission and tetraploidy.

Kumar R, Francis V, Ioannou MS, Aguila A, Khan M, Banks E, Kulasekaran G, McPherson PS
Cell reports 2023 Jul 25;42(7):112795

Anti-inflammation of epicatechin mediated by TMEM35A and TMPO in bovine mammary epithelial cell line cells and mouse mammary gland.

Ma X, Li M, Lu G, Wang R, Wei Y, Guo Y, Yu Y, Jiang C
Journal of dairy science 2021 Dec;104(12):12925-12938

The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus.

Zhang Y, Liu C, Wu B, Li L, Li W, Yuan L
Nature communications 2021 Aug 13;12(1):4926

Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane.

Xu X, Wang D, Zheng C, Gao B, Fan J, Cheng P, Liu B, Yang L, Luo Z
Theranostics 2019;9(8):2252-2267

A toolbox of anti-mouse and anti-rabbit IgG secondary nanobodies.

Pleiner T, Bates M, Görlich D
The Journal of cell biology 2018 Mar 5;217(3):1143-1154

Depletion of thymopoietin inhibits proliferation and induces cell cycle arrest/apoptosis in glioblastoma cells.

Zhang L, Wang G, Chen S, Ding J, Ju S, Cao H, Tian H
World journal of surgical oncology 2016 Oct 19;14(1):267

MacroH2A1 associates with nuclear lamina and maintains chromatin architecture in mouse liver cells.

Fu Y, Lv P, Yan G, Fan H, Cheng L, Zhang F, Dang Y, Wu H, Wen B
Scientific reports 2015 Nov 25;5:17186

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: K-562 cells were subjected to SDS PAGE followed by western blot with 14651-1-AP(TMPO antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human skin cancer using 14651-1-AP(TMPO antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human skin cancer using 14651-1-AP(TMPO antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue