CABT-RM139

antibody from Creative Diagnostics

Targeting: TMPO LAP2, LEMD4, TP

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Chromatin Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

CABT-RM139

Provider

Creative Diagnostics

Product name

Mouse Anti-TMPO monoclonal antibody, clone 9D20-2I22

Antibody type

Monoclonal

Description

Lamina-associated polypeptide 2, isoforms alpha is encoded by the Tmpo gene in murine species. LAP2alpha is a non-membrane bound, oligomeric nucleoplasmic protein that associates directly or indirectly with lamins at specific cell-cycle stages. It is expressed diffusely throughout the nucleus and is involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. It is shown to interact with A-type lamins to control gene expression, transcription, and chromatin organization. The N-terminal part of LAP2alpha contains two structurally independent, non-interacting domains: LEM (LAPEmerin-MAN1)-like domain that binds DNA and a LEM domain that interacts with BANF1. Its C-terminal domain forms a four-stranded coiled coil. Lamin A/C and LAP2alpha complexes predominantly co-occur in euchromatic genomic regions and are shown to be highly mobile. They can bind chromatin in a dynamic manner and are involved in establishing a chromatin environment that is permissive for epigenetic regulation. Loss of LAP2alpha has been linked to increased proliferation of tissue progenitor cells in epidermis, colon, and the hematopoietic system and delayed skeletal muscle differentiation.

Reactivity

Mouse

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG