Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS7981 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- PIGA polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human PIGA.
- Description
- Phosphatidylinositol-glycans (PIGs) are multi-pass transmembrane proteins that localize to the endoplasmic reticulum. PIGs are crucial for the synthesis of N-acetylglucosaminyl-phosphatidylinositol (GlcNAc-PI), a very early intermediate in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The PIG proteins are components of the GPI transamidase complex and play a role in the recognition of either the GPI attachment signal or the lipid portion of GPI. Phospha-tidylinositol glycan class A (PIG-A), an endoplasmic reticulum (ER) transmembrane protein, contains a large cytoplasmic domain, which displays homology to the bacterial GlcNAc transferase RfaK, and a small lumenal domain, which plays a role in targeting the PIG-A protein to the rough ER. PIG-A associates with PIG-C, PIG-H, PIG-P and PIG-Q, as well as DPM2, and interacts directly with PIG-Y. Defects in PIG-A cause paroxysmal nocturnal hemoglobinuria (PNH), an acquired genetic hematologic disorder.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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