SLCO1C1

This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

Description

solute carrier organic anion transporter family member 1C1

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted membrane proteins, Transporters

Chromosome

12:p12.2 (20695355 - 20753386)

Ensembl ID

ENSG00000139155  (ver. 99.38)

Orthologs

Mouse Slco1c1: ENSMUSG00000030235

UniProt

Q9NYB5

neXtProt

NX_Q9NYB5

Human splice variants
Mouse splice variants