28501-1-AP

antibody from Proteintech Group

Targeting: GCH1 DYT14, DYT5, DYT5a, GCH, GTPCH1

Provider product page for 28501-1-AP

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ELISA

Antibody data

Antibody Data
Antigen structure
References [28]
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Product number: 28501-1-AP - Provider product page
Provider: Proteintech Group
Product name: GCH1 antibody
Antibody type: Polyclonal
Description: GCH1 antibody (Cat. #28501-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human and has been validated for the following applications: WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

GCH1 protein structure - 28501-1-AP shown in red.

Submitted references Discovering the abnormalities and functional importance of ferroptosis-related molecules in cervical cancer.

Sun Y, Zhang J, Guo L, Zhang J, Chen Q, Zhang T, Yang J, Zhang Y, Zhen Q, Chi S, Shang G, Cui B, Cui Y, Zhang Y, Zhang Y, Han S
International journal of medical sciences 2026;23(2):443-460

Liquiritigenin targets transferrin receptor to potentiate ferroptosis sensitivity in colorectal cancer cells.

Li R, Song C, Jia T, Xia T, Guo M, Wang Q, Yao Y, Xu X, Bao X, Yang P, Li Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158057

RRM2/GCH1 signaling decreased cisplatin sensitivity in cervical cancer by modulating the ferroptosis process.

Zhao J, Wang L, Shao N, Qu Y, Chen W, Sun H
Histology and histopathology 2026 Mar 6;:25056

TET1 as a master regulator controlling GPX4-dependent and -independent ferroptosis surveillance in acute myeloid leukemia.

Yang L, Lu J, Yun W, Yang X, Sun J, Ge C, Han F, Li X, Min J, Huang H, Wang F, Jiang X
Nature communications 2026 Jan 20;17(1):1800

Regulating the GTP cyclohydrolase 1/tetrahydrobiopterin axis in the distal tubule inhibits ferroptosis and alleviates crush syndrome-related acute kidney injury in mice.

Zhang L, Wang Y, Zhang C, Bao F, Qiao O, Hao H, Hou Y, Saeed S, Wang X, Chen X, Duan X, Wang J, Jin L, Li N, Gong Y
Cellular signalling 2026 Feb;138:112200

Dovitinib Ameliorates Inflammation-Related Diseases by Inhibiting Necroptosis and Ferroptosis.

Lin Y, Feng J, Zhao M, Zhang L, Li Y, Chen X, Lin C, Lin J, Lin Q, Li J, Wu L, Li L
ACS chemical biology 2025 Sep 19;20(9):2191-2203

Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation.

Zhang HL, Guo YQ, Liu S, Ye ZP, Li LC, Hu BX, Li ZL, Chen YH, Feng GK, Shen HQ, Deng R, Zhu XF
Nature chemical biology 2025 Oct;21(10):1531-1543

Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury.

Teng LS, Ying ZD, Sun XH, Hou HC, Qiu SD, Liu P, Li KJ, Zhang L, Sheng XH
Chemico-biological interactions 2025 Nov 1;421:111724

Central biogenic amine deficiency with concomitant exploratory behavioral deficits in Dnajc12 knock-out mice.

Deng IB, Follett J, Fox JD, Wall S, Farrer MJ
NPJ Parkinson's disease 2025 May 30;11(1):143

GPX4-dependent ferroptosis sensitivity is a fitness trade-off for cell enlargement.

Chan KY, Yu Y, Kong Y, Cheng L, Yao R, Yin Chair PS, Wang P, Wang R, Sun WY, He RR, Min J, Wang F, Björklund M
iScience 2025 May 16;28(5):112363

SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation.

Li W, Han J, Huang B, Xu T, Wan Y, Luo D, Kong W, Yu Y, Zhang L, Nian Y, Chu B, Yin C
The EMBO journal 2025 Mar;44(6):1641-1662

Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury.

Zhuang X, Shi S, Liu S, Jiao Y, Huang B, Yang Y, Yang L, Yang X, Wang H, Liang C, Song D, Yu H, Zou D, Sun Q, Yang S, Yin C, Li J, Liu Y, Min J, Wang F, Nian Y, Du L, Chu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(23):e2500566

Nuclear receptor subfamily 1 group D member 2 induces chemoresistance in ovarian cancer by regulating ferroptosis and immune infiltration.

Wang L, Shao N, Qu Y, Sun H, Zhao J
Discover oncology 2025 Jul 1;16(1):1215

S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism.

Yang M, Cui W, Lv X, Xiong G, Sun C, Xuan H, Ma W, Cui X, Cheng Y, Han L, Chu B
Nature communications 2025 Jan 8;16(1):509

Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro.

Liu M, Xie WJ, Zhang X, Wu W, Li G, Wang L
Molecular medicine (Cambridge, Mass.) 2025 Jan 29;31(1):31

Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling.

Liang Y, Ornatowski W, Lu Q, Sun X, Yegambaram M, Feng A, Dong Y, Aggarwal S, Unwalla HJ, Fineman JR, Black SM, Wang T
International journal of molecular sciences 2025 Feb 5;26(3)

Cancer-associated fibroblasts promote doxorubicin resistance in triple-negative breast cancer through enhancing ZFP64 histone lactylation to regulate ferroptosis.

Zhang K, Guo L, Li X, Hu Y, Luo N
Journal of translational medicine 2025 Feb 28;23(1):247

The Nrf2/GPX4 antioxidant pathway suppresses ferroptosis to protect against hearing impairment in cochlear ischemia-reperfusion injury.

Zou T, Huang S, Xie R, Liu J
International immunopharmacology 2025 Dec 10;167:115655

Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator.

Sone M, Mitsuhashi N, Sugiura Y, Matsuoka Y, Maeda R, Yamauchi A, Okahashi R, Yamashita J, Sone K, Enju S, Anegawa D, Yamaguchi Y
Cell death & disease 2024 Sep 19;15(9):685

Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration.

Yang G, Yang Y, Song Z, Chen L, Liu F, Li Y, Jiang S, Xue S, Pei J, Wu Y, He Y, Chu B, Wu H
Neuron 2024 Oct 23;112(20):3452-3469.e9

Upregulation of PRRX2 by silencing Marveld3 as a protective mechanism against radiation-induced ferroptosis in skin cells.

Cao J, Wu M, Mo W, Zhao M, Gu L, Wang X, Zhang B, Cao J
Molecular medicine (Cambridge, Mass.) 2024 Oct 21;30(1):182

Long non‑coding RNA lung cancer‑associated transcript 1 regulates ferroptosis via microRNA‑34a‑5p‑mediated GTP cyclohydrolase 1 downregulation in lung cancer cells.

Tai F, Zhai R, Ding K, Zhang Y, Yang H, Li H, Wang Q, Cao Z, Ge C, Fu H, Xiao F, Zheng X
International journal of oncology 2024 Jun;64(6)

Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition.

Cui W, Guo M, Liu D, Xiao P, Yang C, Huang H, Liang C, Yang Y, Fu X, Zhang Y, Liu J, Shi S, Cong J, Han Z, Xu Y, Du L, Yin C, Zhang Y, Sun J, Gu W, Chai R, Zhu S, Chu B
Nature cell biology 2024 Jan;26(1):124-137

Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene.

Sun Q, Liu D, Cui W, Cheng H, Huang L, Zhang R, Gu J, Liu S, Zhuang X, Lu Y, Chu B, Li J
Communications biology 2023 Nov 1;6(1):1108

Tryptophan Metabolism Acts as a New Anti-Ferroptotic Pathway to Mediate Tumor Growth.

Liu D, Liang CH, Huang B, Zhuang X, Cui W, Yang L, Yang Y, Zhang Y, Fu X, Zhang X, Du L, Gu W, Wang X, Yin C, Chai R, Chu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(6):e2204006

3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation.

Usukhbayar N, Takano Y, Uesugi S, Muroi M, Osada H, Kimura KI
Free radical research 2023 Dec;57(3):208-222

Splicing factor SF3B3, a NS5-binding protein, restricts ZIKV infection by targeting GCH1.

Chen T, Yang H, Liu P, Hamiti M, Zhang X, Xu Y, Quan W, Zhang Y, Yu W, Jiao L, Du T, Xi J, Yin B, Zhou W, Lu S, Peng X
Virologica Sinica 2023 Apr;38(2):222-232

Identification of ferroptosis-related genes for the prediction of prognosis and chemotherapy benefit of gastric cancer.

Zheng JJ, Wang JP
European review for medical and pharmacological sciences 2022 Sep;26(18):6754-6763

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