Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-B9227 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Mouse anti-Human Karyopherin Ï« monoclonal antibody, clone 3
- Antibody type
- Monoclonal
- Description
- The two step process of importing proteins into the nucleus involves the binding and interaction of several cytosolic and nuclear pore proteins. Proteins to be translocated into the nucleus contain a nuclear localization sequence (NLS) which is recognized and bound by carrier proteins in the cytosol. Heterodimers belonging to a highly conserved family of proteins called karyopherins are required for successful nuclear localization of cytosolic proteins. The Ï«-subunits appear to function in the binding of NLS (both simple and bitartite NLS motifs), but both Ï«- and ÉÇ-subunits are required for successful docking to the nuclear envelope. ATP is required for complete translocation of proteins into the nucleus. Karyopherin Ï«2 was first identified as Rch-1, an NLS receptor which interacts with the RAG-1 recombination-activating protein in developing B and T cells. Rch-1 has been reported to be 44% identical to karyopherin Ï«1 (hSRP-1 /NPI-1).
- Reactivity
- Human, Mouse, Rat, Canine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3
- Vial size
- 50ug, 150ug
- Concentration
- 250 Ã×g/ml
- Storage
- Store undiluted at -20°C.
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