BS60589

antibody from Bioworld Technology, Inc
Targeting: AKR1C1 DD1, DDH, DDH1, HAKRC, MBAB
Provider product page for BS60589

Antibody data

Product number
BS60589 - Provider product page
Provider
Bioworld Technology, Inc
Product name
AKR1C1 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human AKR1C1
Description
Human liver contains isoforms of dihydrodiol dehydrogenase (DD1, DD2, DD3 and DD4), which belong to the aldo-oxo reductase/aldo-keto reductase (AKR) superfamily, have 20Ï«- or 3Ï«-hydroxysteroid dehydrogenase (HSD) activity. DD1 is also designated AKR1C1, DDH or DDH1, while DD2 also can be designated AKR1C2, dDD, BABP or DDH2. AKR1C3 and 3Ï«-HSD are alternate designations for human DD3 (which is referred to as AKR1C18 in rodents), while DD4 also can be called AKR1C4, CD, CHDR or AKR1C6 (in rodents). DD1 and DD2 are 20Ï«-HSDs, whereas DD3 and DD4 are the 3Ï«-HSDs. The multiple human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics, such as polycyclic aromatic hydrocarbons, pesticides and steroid hormones, and are responsible for the reduction of ketone-containing drugs by using NADH or NADPH as a cofactor. The 20Ï«-HSD catalyzes the reaction of progesterone to the inactive form 20Ï«-hydroxyprogesterone. The 3Ï«-HSD is a cytosolic, monomeric, NADPH-dependent oxidoreductase that reduces 3-keto-5-dihydrosteroids to their tetrahydro products. DD1 and DD2 are ubiquitously expressed, whereas DD4 mRNA is restricted to the liver. DD3 is a unique enzyme that can specifically catalyze the dehydrogenation of trans-benzenedihydrodiol and trans-naphthalenedihydrodiol.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
AKR1C1 protein structure - BS60589 shown in red.