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- Antibody Data
- Antigen structure
- References [22]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 12091-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- G0S2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated G0S2 antibody (Cat. #12091-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Atractylodin ameliorates obesity-associated hepatic steatosis by regulating the PLIN2-ATGL/CPT1A axis-mediated lipid droplet-mitochondria interactions.
An Extracellular Matrix-Producing Subset of Cancer-Associated Fibroblasts Drives Chemoresistance in Breast Cancer via SRC Activation and G0S2 Upregulation.
Identification of lysosomal lipolysis as an essential noncanonical mediator of adipocyte fasting and cold-induced lipolysis.
FXR as a pivotal role linking JNK and G0s2 mitigates triptolide-induced hepatotoxicity through the regulation of metabolic disorder of liver.
G0S2: a potential target for NSCLC identified through prognostic models from multi-Omic analysis of regulatory T cell metabolic genes.
G0S2 modulates normal vitreous-induced proliferation in endothelial cells.
G0S2 Promotes PD-L1 Expression in Monocytes and Influences the Efficacy of PD-1 Inhibitors in Hepatocellular Carcinoma.
A Neutrophil Extracellular Traps-Related Gene Trait Revealed the Prospective Therapy Strategy of Coronary Atherosclerosis.
Phenotype remodelling of HNSCC cells in the muscle invasion environment.
Male and Female Mitochondria Respond Differently after Exercising in Acute Hypoxia.
Sulfur mustard analog 2-chloroethyl ethyl sulfide increases triglycerides by activating DGAT1-dependent biogenesis and inhibiting PGC1ɑ-dependent fat catabolism in immortalized human bronchial epithelial cells.
G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells.
Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer.
Methyl-CpG-binding domain protein 2 contributes to renal fibrosis through promoting polarized M1 macrophages.
MIN score predicts primary response to infliximab/adalimumab and vedolizumab therapy in patients with inflammatory bowel diseases.
Regulation of lipid metabolism in pancreatic beta cells by interferon gamma: A link to anti-viral function.
Moderate-Intensity Exercise and High-Intensity Interval Training Affect Insulin Sensitivity Similarly in Obese Adults.
Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds.
Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response.
Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues.
G0/G1 Switch Gene 2 controls adipose triglyceride lipase activity and lipid metabolism in skeletal muscle.
Endurance exercise training up-regulates lipolytic proteins and reduces triglyceride content in skeletal muscle of obese subjects.
Chen J, Wei Z, Song Z, Meng S, An J, Zhang Z, Biao Y, Zhang M, Zhang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158134
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158134
An Extracellular Matrix-Producing Subset of Cancer-Associated Fibroblasts Drives Chemoresistance in Breast Cancer via SRC Activation and G0S2 Upregulation.
Hofer I, Kieffer Y, Mencattini A, Croizer H, Mhaidly R, Descroix S, Le Tourneau C, Kamal M, Lamy C, Bonneau C, Cottu PH, Vincent-Salomon A, Martinelli E, Mechta-Grigoriou F, Parrini MC
Cancer research 2026 Feb 16;86(4):1054-1072
Cancer research 2026 Feb 16;86(4):1054-1072
Identification of lysosomal lipolysis as an essential noncanonical mediator of adipocyte fasting and cold-induced lipolysis.
Yeh YS, Evans TD, Iwase M, Jeong SJ, Zhang X, Liu Z, Park A, Ghasemian A, Dianati B, Javaheri A, Kratky D, Kawarasaki S, Goto T, Zhang H, Dutta P, Schopfer FJ, Straub AC, Cho J, Lodhi IJ, Razani B
The Journal of clinical investigation 2025 Mar 17;135(6)
The Journal of clinical investigation 2025 Mar 17;135(6)
FXR as a pivotal role linking JNK and G0s2 mitigates triptolide-induced hepatotoxicity through the regulation of metabolic disorder of liver.
Li Q, Huang J, Zhao Q, Li F
Pharmacological research 2025 Jun;216:107738
Pharmacological research 2025 Jun;216:107738
G0S2: a potential target for NSCLC identified through prognostic models from multi-Omic analysis of regulatory T cell metabolic genes.
Zhou M, Liu M, Hu Y, Xu Z, Cai L, Bai Y, Su L, Sun L
NPJ precision oncology 2025 Jun 19;9(1):198
NPJ precision oncology 2025 Jun 19;9(1):198
G0S2 modulates normal vitreous-induced proliferation in endothelial cells.
Yin Y, Pu L, Yang X, Zhu Y, Chen F, Wu C, Lei H, Wu W
Communications biology 2025 Apr 4;8(1):560
Communications biology 2025 Apr 4;8(1):560
G0S2 Promotes PD-L1 Expression in Monocytes and Influences the Efficacy of PD-1 Inhibitors in Hepatocellular Carcinoma.
Du X, Zhang W, Sun S, Liu C, He Y, Luo F, Wu H, Liu M
Genes 2025 Apr 13;16(4)
Genes 2025 Apr 13;16(4)
A Neutrophil Extracellular Traps-Related Gene Trait Revealed the Prospective Therapy Strategy of Coronary Atherosclerosis.
Li Z, Zhao W, Ji W, Li Z, Wang K, Jiang T
Journal of inflammation research 2024;17:9925-9951
Journal of inflammation research 2024;17:9925-9951
Phenotype remodelling of HNSCC cells in the muscle invasion environment.
Zeng G, Shen Y, Sun W, Lu H, Liang Y, Wu J, Liao G
Journal of translational medicine 2024 Oct 7;22(1):909
Journal of translational medicine 2024 Oct 7;22(1):909
Male and Female Mitochondria Respond Differently after Exercising in Acute Hypoxia.
Lai Y, Loy F, Isola M, Noli R, Rinaldi A, Lobina C, Vargiu R, Cesare Marincola F, Isola R
Biomedicines 2023 Nov 26;11(12)
Biomedicines 2023 Nov 26;11(12)
Sulfur mustard analog 2-chloroethyl ethyl sulfide increases triglycerides by activating DGAT1-dependent biogenesis and inhibiting PGC1ɑ-dependent fat catabolism in immortalized human bronchial epithelial cells.
Ye F, Zeng Q, Dan G, Zhao Y, Yu W, Cheng J, Chen M, Wang B, Zhao J, Sai Y, Zou Z
Toxicology mechanisms and methods 2023 May;33(4):271-278
Toxicology mechanisms and methods 2023 May;33(4):271-278
G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells.
Corbet AK, Bikorimana E, Boyd RI, Shokry D, Kries K, Gupta A, Paton A, Sun Z, Fazal Z, Freemantle SJ, Nelson ER, Spinella MJ, Singh R
Translational oncology 2023 Jul;33:101676
Translational oncology 2023 Jul;33:101676
Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer.
Sela Y, Li J, Maheswaran S, Norgard R, Yuan S, Hubbi M, Doepner M, Xu JP, Ho ES, Mesaros C, Sheehan C, Croley G, Muir A, Blair IA, Shalem O, Dang CV, Stanger BZ
Cancer research 2022 May 16;82(10):1890-1908
Cancer research 2022 May 16;82(10):1890-1908
Methyl-CpG-binding domain protein 2 contributes to renal fibrosis through promoting polarized M1 macrophages.
Ai K, Pan J, Zhang P, Li H, He Z, Zhang H, Li X, Li Y, Yi L, Kang Y, Wang Y, Xiang X, Chai X, Zhang D
Cell death & disease 2022 Feb 8;13(2):125
Cell death & disease 2022 Feb 8;13(2):125
MIN score predicts primary response to infliximab/adalimumab and vedolizumab therapy in patients with inflammatory bowel diseases.
Shi Y, He W, Zhong M, Yu M
Genomics 2021 Jul;113(4):1988-1998
Genomics 2021 Jul;113(4):1988-1998
Regulation of lipid metabolism in pancreatic beta cells by interferon gamma: A link to anti-viral function.
Truong NTT, Lydic TA, Bazil JN, Suryadevara A, Olson LK
Cytokine 2020 Sep;133:155147
Cytokine 2020 Sep;133:155147
Moderate-Intensity Exercise and High-Intensity Interval Training Affect Insulin Sensitivity Similarly in Obese Adults.
Ryan BJ, Schleh MW, Ahn C, Ludzki AC, Gillen JB, Varshney P, Van Pelt DW, Pitchford LM, Chenevert TL, Gioscia-Ryan RA, Howton SM, Rode T, Hummel SL, Burant CF, Little JP, Horowitz JF
The Journal of clinical endocrinology and metabolism 2020 Aug 1;105(8):e2941-59
The Journal of clinical endocrinology and metabolism 2020 Aug 1;105(8):e2941-59
Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds.
Guerrero-Juarez CF, Dedhia PH, Jin S, Ruiz-Vega R, Ma D, Liu Y, Yamaga K, Shestova O, Gay DL, Yang Z, Kessenbrock K, Nie Q, Pear WS, Cotsarelis G, Plikus MV
Nature communications 2019 Feb 8;10(1):650
Nature communications 2019 Feb 8;10(1):650
Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response.
Wang Y, Hou Y, Zhang W, Alvarez AA, Bai Y, Hu B, Cheng SY, Yang K, Li Y, Feng H
Journal of experimental & clinical cancer research : CR 2019 Apr 5;38(1):147
Journal of experimental & clinical cancer research : CR 2019 Apr 5;38(1):147
Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues.
Raajendiran A, Ooi G, Bayliss J, O'Brien PE, Schittenhelm RB, Clark AK, Taylor RA, Rodeheffer MS, Burton PR, Watt MJ
Cell reports 2019 Apr 30;27(5):1528-1540.e7
Cell reports 2019 Apr 30;27(5):1528-1540.e7
G0/G1 Switch Gene 2 controls adipose triglyceride lipase activity and lipid metabolism in skeletal muscle.
Laurens C, Badin PM, Louche K, Mairal A, Tavernier G, Marette A, Tremblay A, Weisnagel SJ, Joanisse DR, Langin D, Bourlier V, Moro C
Molecular metabolism 2016 Jul;5(7):527-537
Molecular metabolism 2016 Jul;5(7):527-537
Endurance exercise training up-regulates lipolytic proteins and reduces triglyceride content in skeletal muscle of obese subjects.
Louche K, Badin PM, Montastier E, Laurens C, Bourlier V, de Glisezinski I, Thalamas C, Viguerie N, Langin D, Moro C
The Journal of clinical endocrinology and metabolism 2013 Dec;98(12):4863-71
The Journal of clinical endocrinology and metabolism 2013 Dec;98(12):4863-71
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 12091-1-AP( G0S2 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The G0S2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human G0S2. This antibody recognizes human,mouse,rat antigen. The G0S2 antibody has been validated for the following applications: ELISA, IF, WB analysis.
