BS7816

antibody from Bioworld Technology, Inc

Targeting: CRYAA CRYA1, HSPB4

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS7816

Provider

Bioworld Technology, Inc

Product name

CRYAA polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human CRYAA.

Description

Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into Ï«, ÉÇ and ÎÛ families, and the ÉÇ- and ÎÛ-crystallins also compose a superfamily. Crystallins usually contain seven distinct protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Ï«-crystallins consist of three gene products, Ï«A, Ï«B and Ï«C-crystallin, which are members of the small heat shock protein family (HSP 20). They are induced by heat shock, and act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, Ï«-crystallins do not renature these proteins. Expression of Ï«A-crystallin is restricted to the lens. Defects in this gene cause autosomal dominant congenital cataracts (ADCC). The human Ï«B-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of Ï«B-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.