Tissue expression
Cell line expression
Protein structure
GRPR
Gastrin releasing peptide receptorBB2, BB2R
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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antibodies-online | ABIN952465 | 5 references | Polyclonal |
WB
IHC
FC
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Invitrogen Antibodies | OPA1-15619 | 6 references | Polyclonal |
IHC
OA |
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LSBio | LS-C402313 | Polyclonal |
WB
EL
IHC
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Acris Antibodies GmbH | AP51959PU-N | Polyclonal |
WB
IHC
FC
|
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OriGene | AP51959PU-N | Polyclonal |
WB
IHC
FC
|
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