11134-1-AP

antibody from Proteintech Group

Targeting: ACO2 ACONM

Provider product page for 11134-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [37]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 11134-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11134-1-AP, RRID:AB_2289288
Product name: Aconitase 2 antibody
Antibody type: Polyclonal
Description: Aconitase 2 antibody (Cat. #11134-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ACO2 protein structure - 11134-1-AP shown in red.

Submitted references Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells.

Feng H, Li Z, Zhang H, Zheng Y, Xu B, Zhang Y, Zou L, Wu L
Nucleic acids research 2026 Feb 5;54(4)

Mitochondrial uncoupling sensitizes gastric cancer cells to elesclomol-induced cuproptosis via FDX1/DLAT upregulation.

Lu Y, Li Y, Sun X, Li X, Zhao S, Fang Y, Qiu W, Luo C, Qi W
Free radical biology & medicine 2026 Feb 16;244:284-295

m6A Modification of ATOX1 Inhibits Acute Myeloid Leukemia Progression by Promoting Cuproptosis.

Peng J, Fu X, Li S, Hu C, Zhao X, Peng J
Cancer research communications 2026 Apr 1;6(4):714-727

Yttrium Oxide Nanoparticles Affect Both Cognitive and Memory Function by Disrupting Copper Output in Neuronal Cells in a Rat Model.

Zheng M, Chen Z, Xie J, Yang Q, Mo M, Chen L
International journal of nanomedicine 2025;20:5799-5815

Bushen Huatan formula alleviates polycystic ovary syndrome in rats by activating the PI3K/Akt pathway to inhibit GSDMD-mediated pyroptosis and mitochondrial damage.

Xiong Q, Yang J, Liu Q, Yu P, Shen M, Liang J
Journal of ovarian research 2025 Nov 24;18(1):309

Dual regulation of mitochondrial fusion by Parkin-PINK1 and OMA1.

Yamada T, Ikeda A, Murata D, Wang H, Zhang C, Khare P, Adachi Y, Ito F, Quirós PM, Blackshaw S, López-Otín C, Langer T, Chan DC, Le A, Dawson VL, Dawson TM, Iijima M, Sesaki H
Nature 2025 Mar;639(8055):776-783

Analysis and identification of mitochondria-related genes associated with age-related hearing loss.

Ma T, Zeng X, Liu M, Xu S, Wang Y, Wu Q, Zhang T
BMC genomics 2025 Mar 5;26(1):218

Succinate dehydrogenase activity supports de novo purine synthesis.

Nengroo MA, Klein AT, Carr HS, Vidal-Cruchez O, Sahu U, McGrail DJ, Sahni N, Gao P, Asara JM, Shah H, Mendillo ML, Ben-Sahra I
bioRxiv : the preprint server for biology 2025 Mar 1;

Role of DLAT in cuproptosis and autophagy in hippocampal tissue of PTSD rats with high-voltage electrical burns.

Ge C, Zhao X, Zhang J, Li P, Hao J, Lu M, Li C, Ge L, Tu L, Zhang Q
Burns : journal of the International Society for Burn Injuries 2025 Jun;51(5):107519

Low expression of Frataxin might contribute to diabetic peripheral neuropathy in a mouse model.

Xia S, Wu L, Chen J, Li K, Bian D
Biochemical and biophysical research communications 2025 Jan;744:151228

LONP1 Promotes Hepatocarcinogenesis by Degrading ACO2 to Alleviate Ferroptosis.

Zhong Y, Wu L, Peng Z, Mao W, Wang T, Wu B, Yu Z, Li X, Chen E
Frontiers in bioscience (Landmark edition) 2025 Aug 29;30(8):41226

Protein lactylation of citrate synthase promotes the AKI-CKD transition by activating the NLRP3 inflammasome.

Yu F, Meng Y, Wang X, Chen J, He J, Yi X, He Y, Chen K
Cell reports 2025 Aug 26;44(8):116084

Novel Insights Into DLAT's Role in Alzheimer's Disease-Related Copper Toxicity Through Microglial Exosome Dynamics.

Ma X, Sun Y, Li C, Wang M, Zang Q, Zhang X, Wang F, Niu Y, Hua J
CNS neuroscience & therapeutics 2024 Oct;30(10):e70064

O-GlcNAcylation Facilitates the Interaction between Keratin 18 and Isocitrate Dehydrogenases and Potentially Influencing Cholangiocarcinoma Progression.

Meng X, Zhou Y, Xu L, Hu L, Wang C, Tian X, Zhang X, Hao Y, Cheng B, Ma J, Wang L, Liu J, Xie R
ACS central science 2024 May 22;10(5):1065-1083

Systemic phospho-defective and phospho-mimetic Drp1 mice exhibit normal growth and development with altered anxiety-like behavior.

Ikeda A, Iijima M, Sesaki H
iScience 2024 Jun 21;27(6):109874

Intermittent Theta Burst Stimulation Attenuates Cognitive Deficits and Alzheimer's Disease-Type Pathologies via ISCA1-Mediated Mitochondrial Modulation in APP/PS1 Mice.

Zhu Y, Huang H, Chen Z, Tao Y, Liao LY, Gao SH, Wang YJ, Gao CY
Neuroscience bulletin 2024 Feb;40(2):182-200

UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation.

Ahlstedt BA, Ganji R, Mukkavalli S, Paulo JA, Gygi SP, Raman M
EMBO reports 2024 Feb;25(2):672-703

Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers.

Liu C, Chen L, Cong Y, Cheng L, Shuai Y, Lv F, Chen K, Song Y, Xing Y
Cell death & disease 2024 Feb 16;15(2):149

In-Gel Activity Assay of Mammalian Mitochondrial and Cytosolic Aconitases, Surrogate Markers of Compartment-Specific Oxidative Stress and Iron Status.

Tong WH, Rouault TA
Bio-protocol 2024 Dec 5;14(23):e5126

Mammalian SLC39A13 promotes ER/Golgi iron transport and iron homeostasis in multiple compartments.

Li H, Cui Y, Hu Y, Zhao M, Li K, Pang X, Sun F, Zhou B
Nature communications 2024 Dec 30;15(1):10838

TRIM24-DTNBP1-ATP7A mediated astrocyte cuproptosis in cognition and memory dysfunction caused by Y(2)O(3) NPs.

Chen Z, Liu J, Zheng M, Mo M, Hu X, Liu C, Pathak JL, Wang L, Chen L
The Science of the total environment 2024 Dec 1;954:176353

Downregulation of Iron-Sulfur Cluster Biogenesis May Contribute to Hyperglycemia-Mediated Diabetic Peripheral Neuropathy in Murine Models.

Wu L, Huang F, Sun Z, Zhang J, Xia S, Zhao H, Liu Y, Yang L, Ding Y, Bian D, Li K, Sun Y
Antioxidants (Basel, Switzerland) 2024 Aug 26;13(9)

Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth.

Zhao H, Zhang M, Zhang J, Sun Z, Zhang W, Dong W, Cheng C, Yao Y, Li K
Cell & bioscience 2023 May 13;13(1):87

Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging.

Yuan M, Wang Y, Wen J, Jing F, Zou Q, Pu Y, Pan T, Cai Z
Aging and disease 2022 Oct 1;13(5):1532-1545

Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2.

Sun LY, Lyu YY, Zhang HY, Shen Z, Lin GQ, Geng N, Wang YL, Huang L, Feng ZH, Guo X, Lin N, Ding S, Yuan AC, Zhang L, Qian K, Pu J
Circulation 2022 Nov 22;146(21):1591-1609

Cur@SF NPs alleviate Friedreich's ataxia in a mouse model through synergistic iron chelation and antioxidation.

Xu L, Sun Z, Xing Z, Liu Y, Zhao H, Tang Z, Luo Y, Hao S, Li K
Journal of nanobiotechnology 2022 Mar 9;20(1):118

Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis.

Wang YP, Sharda A, Xu SN, van Gastel N, Man CH, Choi U, Leong WZ, Li X, Scadden DT
Cell metabolism 2021 May 4;33(5):1027-1041.e8

Proteomic Profile of Sperm in Infertile Males Reveals Changes in Metabolic Pathways.

Liang J, Zheng Y, Zeng W, Chen L, Yang S, Du P, Wang Y, Yu X, Zhang X
The protein journal 2021 Dec;40(6):929-939

Bioenergetic functions in subpopulations of heart mitochondria are preserved in a non-obese type 2 diabetes rat model (Goto-Kakizaki).

Lai N, Kummitha CM, Loy F, Isola R, Hoppel CL
Scientific reports 2020 Mar 25;10(1):5444

The Symbiotic Relationship between the Neural Retina and Retinal Pigment Epithelium Is Supported by Utilizing Differential Metabolic Pathways.

Sinha T, Naash MI, Al-Ubaidi MR
iScience 2020 Apr 24;23(4):101004

Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75.

Li C, Chen W, Zheng L, Zhang B, Yang X, Zhang Q, Wang N, Wang Y, Yang J, Sha J, Zhou Z, Li X, Li Y, Shen XL
Toxicon : official journal of the International Society on Toxinology 2019 Oct;168:141-146

miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism.

Muys BR, Sousa JF, Plaça JR, de Araújo LF, Sarshad AA, Anastasakis DG, Wang X, Li XL, de Molfetta GA, Ramão A, Lal A, Vidal DO, Hafner M, Silva WA
Cancer research 2019 Jul 1;79(13):3294-3305

Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.

Li H, Zhao H, Hao S, Shang L, Wu J, Song C, Meyron-Holtz EG, Qiao T, Li K
Scientific reports 2018 Mar 23;8(1):5118

Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.

Chen CM, Wu YR, Chang KH
International journal of molecular sciences 2017 Nov 21;18(11)

A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.

Pryde KR, Taanman JW, Schapira AH
Cell reports 2016 Dec 6;17(10):2522-2531

Tumor Necrosis Factor-Associated Protein 1 (TRAP1) is Released from the Mitochondria Following 6-hydroxydopamine Treatment.

Shin DI, Oh YJ
Experimental neurobiology 2014 Mar;23(1):65-76

A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism.

Cai Z, Zhao JS, Li JJ, Peng DN, Wang XY, Chen TL, Qiu YP, Chen PP, Li WJ, Xu LY, Li EM, Tam JP, Qi RZ, Jia W, Xie D
Molecular & cellular proteomics : MCP 2010 Dec;9(12):2617-28

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 11134-1-AP(ACO2 antibody) at dilution of 1:400
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Aconitase 2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Aconitase 2. This antibody recognizes human,mouse,rat antigen. The Aconitase 2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 11134-1-AP.pdf

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