Antibody data
- Antibody Data
- Antigen structure
- References [23]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 15401-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15401-1-AP, RRID:AB_2166532
- Product name
- PPAT antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PPAT antibody (Cat. #15401-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model.
The Role of Purine Metabolism-Related Genes PPAT and IMPDH1 in the Carcinogenesis of Intrahepatic Cholangiocarcinoma Based on Metabonomic and Bioinformatic Analyses.
Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1.
A mitochondrial iron-responsive pathway regulated by DELE1.
Cyclin D1 extensively reprograms metabolism to support biosynthetic pathways in hepatocytes.
Therapeutic targeting of glutamate dehydrogenase 1 that links metabolic reprogramming and Snail-mediated epithelial-mesenchymal transition in drug-resistant lung cancer.
SHMT2 promotes the tumorigenesis of renal cell carcinoma by regulating the m6A modification of PPAT.
Species-Specific Deamidation of RIG-I Reveals Collaborative Action between Viral and Cellular Deamidases in HSV-1 Lytic Replication.
Targeting Subtype-Specific Metabolic Preferences in Nucleotide Biosynthesis Inhibits Tumor Growth in a Breast Cancer Model.
Mitochondrial NADP(+) is essential for proline biosynthesis during cell growth.
UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism.
A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer.
ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis.
Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes.
Effect and Mechanism of Tanshinone I on the Radiosensitivity of Lung Cancer Cells.
The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels.
Menin enhances c-Myc-mediated transcription to promote cancer progression.
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.
Aripiprazole increases NAD(P)H-quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells.
Potent effects of dioscin against obesity in mice.
Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus.
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.
Fu Y, Chen YS, Xia DY, Luo XD, Luo HT, Pan J, Ma WQ, Li JZ, Mo QY, Tu Q, Li MM, Zhao Y, Li Y, Huang YT, Chen ZX, Li ZJ, Bernard L, Dione M, Zhang YM, Miao K, Chen JY, Zhu SS, Ren J, Zhou LJ, Jiang XZ, Chen J, Lin ZP, Chen JP, Ye H, Cao QY, Zhu YW, Yang L, Wang X, Wang WC
NPJ biofilms and microbiomes 2024 Mar 20;10(1):25
NPJ biofilms and microbiomes 2024 Mar 20;10(1):25
The Role of Purine Metabolism-Related Genes PPAT and IMPDH1 in the Carcinogenesis of Intrahepatic Cholangiocarcinoma Based on Metabonomic and Bioinformatic Analyses.
Liu CJ, Ma ZZ, Gong WZ, Mao XH, Wen HQ, Wang XH
Journal of oncology 2023;2023:5141836
Journal of oncology 2023;2023:5141836
Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1.
Du H, Yang YC, Liu HJ, Yuan M, Asara JM, Wong KK, Henske EP, Singh M, Kwiatkowski DJ
The Journal of clinical investigation 2023 Nov 1;133(21)
The Journal of clinical investigation 2023 Nov 1;133(21)
A mitochondrial iron-responsive pathway regulated by DELE1.
Sekine Y, Houston R, Eckl EM, Fessler E, Narendra DP, Jae LT, Sekine S
Molecular cell 2023 Jun 15;83(12):2059-2076.e6
Molecular cell 2023 Jun 15;83(12):2059-2076.e6
Cyclin D1 extensively reprograms metabolism to support biosynthetic pathways in hepatocytes.
Wu H, Kren BT, Lane AN, Cassel TA, Higashi RM, Fan TWM, Scaria GS, Shekels LL, Klein MA, Albrecht JH
The Journal of biological chemistry 2023 Dec;299(12):105407
The Journal of biological chemistry 2023 Dec;299(12):105407
Therapeutic targeting of glutamate dehydrogenase 1 that links metabolic reprogramming and Snail-mediated epithelial-mesenchymal transition in drug-resistant lung cancer.
Wang Q, Wu M, Li H, Rao X, Ao L, Wang H, Yao L, Wang X, Hong X, Wang J, Aa J, Sun M, Wang G, Liu J, Zhou F
Pharmacological research 2022 Nov;185:106490
Pharmacological research 2022 Nov;185:106490
SHMT2 promotes the tumorigenesis of renal cell carcinoma by regulating the m6A modification of PPAT.
Huo FC, Xie M, Zhu ZM, Zheng JN, Pei DS
Genomics 2022 Jul;114(4):110424
Genomics 2022 Jul;114(4):110424
Species-Specific Deamidation of RIG-I Reveals Collaborative Action between Viral and Cellular Deamidases in HSV-1 Lytic Replication.
Huang H, Zhao J, Wang TY, Zhang S, Zhou Y, Rao Y, Qin C, Liu Y, Chen Y, Xia Z, Feng P
mBio 2021 Mar 30;12(2)
mBio 2021 Mar 30;12(2)
Targeting Subtype-Specific Metabolic Preferences in Nucleotide Biosynthesis Inhibits Tumor Growth in a Breast Cancer Model.
Ogrodzinski MP, Teoh ST, Lunt SY
Cancer research 2021 Jan 15;81(2):303-314
Cancer research 2021 Jan 15;81(2):303-314
Mitochondrial NADP(+) is essential for proline biosynthesis during cell growth.
Tran DH, Kesavan R, Rion H, Soflaee MH, Solmonson A, Bezwada D, Vu HS, Cai F, Phillips JA 3rd, DeBerardinis RJ, Hoxhaj G
Nature metabolism 2021 Apr;3(4):571-585
Nature metabolism 2021 Apr;3(4):571-585
UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism.
Feng X, Ma D, Zhao J, Song Y, Zhu Y, Zhou Q, Ma F, Liu X, Zhong M, Liu Y, Xiong Y, Qiu X, Zhang Z, Zhang H, Zhao Y, Zhang K, Hong X, Zhang Z
The EMBO journal 2020 Mar 2;39(5):e102541
The EMBO journal 2020 Mar 2;39(5):e102541
A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer.
Kodama M, Oshikawa K, Shimizu H, Yoshioka S, Takahashi M, Izumi Y, Bamba T, Tateishi C, Tomonaga T, Matsumoto M, Nakayama KI
Nature communications 2020 Mar 17;11(1):1320
Nature communications 2020 Mar 17;11(1):1320
ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis.
Ali ES, Sahu U, Villa E, O'Hara BP, Gao P, Beaudet C, Wood AW, Asara JM, Ben-Sahra I
Molecular cell 2020 Jun 18;78(6):1178-1191.e6
Molecular cell 2020 Jun 18;78(6):1178-1191.e6
Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes.
Paul BT, Tesfay L, Winkler CR, Torti FM, Torti SV
Scientific reports 2019 Dec 23;9(1):19634
Scientific reports 2019 Dec 23;9(1):19634
Effect and Mechanism of Tanshinone I on the Radiosensitivity of Lung Cancer Cells.
Yan Y, Su W, Zeng S, Qian L, Chen X, Wei J, Chen N, Gong Z, Xu Z
Molecular pharmaceutics 2018 Nov 5;15(11):4843-4853
Molecular pharmaceutics 2018 Nov 5;15(11):4843-4853
The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels.
Hoxhaj G, Hughes-Hallett J, Timson RC, Ilagan E, Yuan M, Asara JM, Ben-Sahra I, Manning BD
Cell reports 2017 Oct 31;21(5):1331-1346
Cell reports 2017 Oct 31;21(5):1331-1346
Menin enhances c-Myc-mediated transcription to promote cancer progression.
Wu G, Yuan M, Shen S, Ma X, Fang J, Zhu L, Sun L, Liu Z, He X, Huang D, Li T, Li C, Wu J, Hu X, Li Z, Song L, Qu K, Zhang H, Gao P
Nature communications 2017 May 5;8:15278
Nature communications 2017 May 5;8:15278
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.
Ben-Sahra I, Hoxhaj G, Ricoult SJH, Asara JM, Manning BD
Science (New York, N.Y.) 2016 Feb 12;351(6274):728-733
Science (New York, N.Y.) 2016 Feb 12;351(6274):728-733
Aripiprazole increases NAD(P)H-quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells.
Kaneko YS, Takayanagi T, Nagasaki H, Kodani Y, Nakashima A, Mori K, Suzuki A, Itoh M, Kondo K, Nagatsu T, Ota M, Ota A
Journal of neural transmission (Vienna, Austria : 1996) 2015 Jun;122(6):757-72
Journal of neural transmission (Vienna, Austria : 1996) 2015 Jun;122(6):757-72
Potent effects of dioscin against obesity in mice.
Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973
Scientific reports 2015 Jan 22;5:7973
Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus.
Sugiyama K, Ebinuma H, Nakamoto N, Sakasegawa N, Murakami Y, Chu PS, Usui S, Ishibashi Y, Wakayama Y, Taniki N, Murata H, Saito Y, Fukasawa M, Saito K, Yamagishi Y, Wakita T, Takaku H, Hibi T, Saito H, Kanai T
PloS one 2014;9(4):e94460
PloS one 2014;9(4):e94460
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2014 Dec;5(12):3065-3075
Food & function 2014 Dec;5(12):3065-3075
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.
Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, Yamamoto M, Motohashi H
Cancer cell 2012 Jul 10;22(1):66-79
Cancer cell 2012 Jul 10;22(1):66-79
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PPAT antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PPAT. This antibody recognizes human, mouse, rat antigen. The PPAT antibody has been validated for the following applications: ELISA, WB analysis.