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- References [18]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 12967-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12967-1-AP, RRID:AB_10638449
- Product name
- PAICS antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PAICS antibody (Cat. #12967-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references GART promotes the proliferation and migration of human non-small cell lung cancer cell lines A549 and H1299 by targeting PAICS-Akt-β-catenin pathway.
LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma.
Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress.
The secreted metabolite sensor CtBP2 links metabolism to healthy lifespan.
Metabolomic and transcriptomic profiling of HNSCC identifies AMIGO2 as a therapeutic target modulating tumor microenvironment.
ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation.
Resilience and vulnerabilities of tumor cells under purine shortage stress.
Role of CENPL, DARS2, and PAICS in determining the prognosis of patients with lung adenocarcinoma.
Genome-scale CRISPR-Cas9 screen identifies PAICS as a therapeutic target for EGFR wild-type non-small cell lung cancer.
De novo and salvage purine synthesis pathways across tissues and tumors.
Optimization of protocols for immunohistochemical assessment of enteric nervous system in formalin fixed human tissue.
Generation of a Rat Monoclonal Antibody for Human PAICS, a de novo Purine Biosynthetic Enzyme.
LncRNA BCAN-AS1 stabilizes c-Myc via N(6)-methyladenosine-mediated binding with SNIP1 to promote pancreatic cancer.
Spatiotemporal Regulation of De Novo and Salvage Purine Synthesis during Brain Development.
Therapeutic targeting of metabolic vulnerabilities in cancers with MLL3/4-COMPASS epigenetic regulator mutations.
Nwd1 Regulates Neuronal Differentiation and Migration through Purinosome Formation in the Developing Cerebral Cortex.
ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis.
Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines.
Chen Z, Ding YH, Zhao MQ, Zhang YJ, Sun MY, Zhang AQ, Qian X, Ji XM
Frontiers in oncology 2025;15:1543463
Frontiers in oncology 2025;15:1543463
LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma.
Zhang Y, Zhou Y, Zhang Y, Lv J, Shen Y, Zhang D, Liu B, Zhao W, Ju J, Zhu Q, Wang K, Feng N
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e16809
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e16809
Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress.
Yu J, Jin C, Su C, Moon D, Sun MA, Zhang H, Jiang X, Zhang F, Tserentsoodol N, Bowie ML, Pirozzi CJ, George DJ, Wild R, Gao X, Ashley DM, He Y, Huang J
Clinical cancer research : an official journal of the American Association for Cancer Research 2025 Oct 15;31(20):4345-4360
Clinical cancer research : an official journal of the American Association for Cancer Research 2025 Oct 15;31(20):4345-4360
The secreted metabolite sensor CtBP2 links metabolism to healthy lifespan.
Sekiya M, Kainoh K, Chen W, Yamazaki D, Tsuyuzaki T, Kobari Y, Nakata A, Saito K, Aono-Soma N, Majid A, Ohno H, Miyamoto T, Matsuzaka T, Nakajima R, Matsuda T, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Shimano H
Nature aging 2025 Nov;5(11):2197-2214
Nature aging 2025 Nov;5(11):2197-2214
Metabolomic and transcriptomic profiling of HNSCC identifies AMIGO2 as a therapeutic target modulating tumor microenvironment.
Liu G, Yao X, Hou Y, Deng W, Zhang L, Li S, Huang P, Chang W, Huang H, Shi L, Zhou Q, Wang Y, Chen J, Gu W, Ma X, Zhou Y, Liu H, Zhang S, Yang Z
NPJ precision oncology 2025 Nov 18;9(1):358
NPJ precision oncology 2025 Nov 18;9(1):358
ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation.
Yang L, You J, Yang X, Jiao R, Xu J, Zhang Y, Mi W, Zhu L, Ye Y, Ren R, Min D, Tang M, Chen L, Li F, Liu P
Nature communications 2025 Feb 28;16(1):2071
Nature communications 2025 Feb 28;16(1):2071
Resilience and vulnerabilities of tumor cells under purine shortage stress.
Yu J, Jin C, Su C, Moon D, Sun M, Zhang H, Jiang X, Zhang F, Tserentsoodol N, Bowie ML, Pirozzi CJ, George DJ, Wild R, Gao X, Ashley DM, He Y, Huang J
bioRxiv : the preprint server for biology 2025 Apr 12;
bioRxiv : the preprint server for biology 2025 Apr 12;
Role of CENPL, DARS2, and PAICS in determining the prognosis of patients with lung adenocarcinoma.
Xu R, Han F, Zhao Y, Liu A, An N, Wang B, Zardo P, Sanz-Santos J, Franssen AJPM, de Loos ER, Zhao M
Translational lung cancer research 2024 Oct 31;13(10):2729-2745
Translational lung cancer research 2024 Oct 31;13(10):2729-2745
Genome-scale CRISPR-Cas9 screen identifies PAICS as a therapeutic target for EGFR wild-type non-small cell lung cancer.
Li Y, Zhu L, Mao J, Zheng H, Hu Z, Yang S, Mao T, Zhou T, Cao P, Wu H, Wang X, Wang J, Lin F, Shen H
MedComm 2024 Mar;5(3):e483
MedComm 2024 Mar;5(3):e483
De novo and salvage purine synthesis pathways across tissues and tumors.
Tran DH, Kim D, Kesavan R, Brown H, Dey T, Soflaee MH, Vu HS, Tasdogan A, Guo J, Bezwada D, Al Saad H, Cai F, Solmonson A, Rion H, Chabatya R, Merchant S, Manales NJ, Tcheuyap VT, Mulkey M, Mathews TP, Brugarolas J, Morrison SJ, Zhu H, DeBerardinis RJ, Hoxhaj G
Cell 2024 Jul 11;187(14):3602-3618.e20
Cell 2024 Jul 11;187(14):3602-3618.e20
Optimization of protocols for immunohistochemical assessment of enteric nervous system in formalin fixed human tissue.
Hong SM, Qian X, Deshpande V, Kulkarni S
bioRxiv : the preprint server for biology 2024 Dec 17;
bioRxiv : the preprint server for biology 2024 Dec 17;
Generation of a Rat Monoclonal Antibody for Human PAICS, a de novo Purine Biosynthetic Enzyme.
Yokoyama C, Bando K, Yamagata M, Nagasaki T, Tachibana T
Monoclonal antibodies in immunodiagnosis and immunotherapy 2024 Aug;43(4):108-111
Monoclonal antibodies in immunodiagnosis and immunotherapy 2024 Aug;43(4):108-111
LncRNA BCAN-AS1 stabilizes c-Myc via N(6)-methyladenosine-mediated binding with SNIP1 to promote pancreatic cancer.
Wu G, Su J, Zeng L, Deng S, Huang X, Ye Y, Li R, Bai R, Zhuang L, Li M, Zhou Q, Zheng Y, Deng J, Zhang S, Chen R, Lin D, Zhang J, Zheng J
Cell death and differentiation 2023 Oct;30(10):2213-2230
Cell death and differentiation 2023 Oct;30(10):2213-2230
Spatiotemporal Regulation of De Novo and Salvage Purine Synthesis during Brain Development.
Mizukoshi T, Yamada S, Sakakibara SI
eNeuro 2023 Oct;10(10)
eNeuro 2023 Oct;10(10)
Therapeutic targeting of metabolic vulnerabilities in cancers with MLL3/4-COMPASS epigenetic regulator mutations.
Zhao Z, Cao K, Watanabe J, Philips CN, Zeidner JM, Ishi Y, Wang Q, Gold SR, Junkins K, Bartom ET, Yue F, Chandel NS, Hashizume R, Ben-Sahra I, Shilatifard A
The Journal of clinical investigation 2023 Jul 3;133(13)
The Journal of clinical investigation 2023 Jul 3;133(13)
Nwd1 Regulates Neuronal Differentiation and Migration through Purinosome Formation in the Developing Cerebral Cortex.
Yamada S, Sato A, Sakakibara SI
iScience 2020 May 22;23(5):101058
iScience 2020 May 22;23(5):101058
ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis.
Ali ES, Sahu U, Villa E, O'Hara BP, Gao P, Beaudet C, Wood AW, Asara JM, Ben-Sahra I
Molecular cell 2020 Jun 18;78(6):1178-1191.e6
Molecular cell 2020 Jun 18;78(6):1178-1191.e6
Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines.
Meng M, Chen Y, Jia J, Li L, Yang S
Biological research 2018 Aug 10;51(1):24
Biological research 2018 Aug 10;51(1):24
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Raji cells were subjected to SDS PAGE followed by western blot with 12967-1-AP(PAICS antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 12967-1-AP(PAICS antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PAICS antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PAICS. This antibody recognizes human,mouse,rat antigen. The PAICS antibody has been validated for the following applications: ELISA, WB, IHC analysis.
