FBXO34

Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). [supplied by OMIM, Mar 2008]

Description

F-box protein 34

Tissue specificity

Low tissue specificity

Subcell location

Nuclear speckles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

14 (55271344 - 55370053)

Ensembl ID

ENSG00000178974  (ver. 103.38)

Orthologs

Mouse Fbxo34: ENSMUSG00000037536

UniProt

Q9NWN3

neXtProt

NX_Q9NWN3

Human splice variants
Mouse splice variants

Protein structure