11419-1-AP

antibody from Proteintech Group

Targeting: HOPX HOP, LAGY, NECC1, OB1, SMAP31

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunoprecipitation (Supportive data in Antibodypedia)

Antibody Data

Product number

11419-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#11419-1-AP, RRID:AB_10693525

Product name

HOPX antibody

Antibody type

Polyclonal

Description

HOPX antibody (Cat. #11419-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Lysine attenuates acute lung injury by restoring α-tubulin acetylation and ciliary activity.

Yang W, Meng X, Zhu Y, Ma X, Cao Z, Wang M, Dai W, Tao Y, Jian X, Tian R, Yang Z, Wang R
Cell death discovery 2026 Mar 16;12(1)

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Two translocation mechanisms drive neural stem cell dissemination into the human fetal cortex.

Wimmer R, Brunet Avalos C, Lestienne P, Coquand L, Di Cicco A, Chehade C, Artioli A, Cortes M, Macé AS, Wang X, Manneville JB, Bessière B, Roy A, Forsberg-Nilsson K, Ladewig J, Guimiot F, Baffet AD
Neuron 2026 Mar 16;

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Human organoid tumor transplantation identifies functional glioblastoma-microenvironment communication mediated by PTPRZ1.

Ge W, Kan RL, Yilgor C, Fazzari E, Nano PR, Azizad DJ, Shinglot H, Li M, Ito JY, Tse C, Tum HA, Scholes J, Baisiwala S, Patel KS, Nathanson DA, Bhaduri A
Cell reports 2026 Jan 27;45(1):116848

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TSC tunes progenitor balance and upper-layer neuron generation in neocortex.

Casingal CR, Nakagawa N, Yabuno-Nakagawa K, Meyer C, Liu S, Gkini V, Cho SJ, Skarica M, Liang D, Simon JM, Matoba N, Mallick A, Singla R, Park J, Huang CW, Wilson H, Lee J, Ghashghaei HT, Stuber GD, Heikinheimo O, Namba T, Stein JL, Anton ES
Nature 2026 Feb;650(8101):417-427

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p53 Drives Lung Cancer Regression through a TSC2/TFEB-dependent Senescence Program.

Wang M, Bieging-Rolett KT, Kaiser AM, Brady CA, Lockhart JH, Ferreira S, Nguyen KT, Rajeevan A, Evans SA, Zhao T, Raj N, Elkrief A, Tischfield SE, Ladanyi M, Ozawa MG, Bui NQ, Chen CT, Flores ER, Attardi LD
Cancer discovery 2026 Feb 6;16(2):391-411

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DNMT3b promotes proliferation and invasion by mediating HOPX DNA methylation in lung cancer.

Guan K, Zhao S, Zhang G, Wang Y, Song D, Ding Y
iScience 2026 Feb 20;29(2):114347

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Single-cell transcriptomics reveals apolipoprotein A4-mediated metabolic-immune reprogramming in lymphocytes during early obesity-related chronic kidney disease.

Wei Y, Zhang T, Jin Y, Liu X, Zhou J, Huang N, Wang Y
Acta biochimica et biophysica Sinica 2025 Sep 25;57(12):1939-52

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Molecular signatures and lineage diversification of neurogenic and gliogenic radial glia in the gyrencephalic ferret cortex.

Li J, Yang F, Li W, Fu T, Li Z, Sha Z, Zheng W, Yang C, Yu J, Han D, Jiang X, You Y, Li X, Ma T, He M, Xu Z, Song X, Chen B, Ding J, Wang X, Zhang Z, Yang Z
Research square 2025 Nov 28;

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Integrated analysis of molecular atlases unveils modules driving developmental cell subtype specification in the human cortex.

Nano PR, Fazzari E, Azizad D, Martija A, Nguyen CV, Wang S, Giang V, Kan RL, Yoo J, Wick B, Haeussler M, Bhaduri A
Nature neuroscience 2025 May;28(5):949-963

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Metabolic Atlas of Early Human Cortex Identifies Regulators of Cell Fate Transitions.

Mil J, Soto JA, Matulionis N, Krall A, Day F, Stiles L, Montales KP, Azizad DJ, Gonzalez CE, Nano PR, Martija AA, Perez-Ramirez CA, Nguyen CV, Kan RL, Andrews MG, Christofk HR, Bhaduri A
bioRxiv : the preprint server for biology 2025 Mar 11;

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Single-cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism.

Perez Y, Velmeshev D, Wang L, White ML, Siebert C, Baltazar J, Zuo G, Moriano JA, Chen S, Steffen DM, Dutton NG, Wang S, Wick B, Haeussler M, Chamberlain S, Alvarez-Buylla A, Kriegstein A
Nature communications 2025 Jul 4;16(1):6177

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α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex.

Mukhtar T, Siebert CV, Wang Y, Pebworth MP, White ML, Wu T, Huang TI, Zuo G, Ross J, Baltazar J, Upadhyay V, Shankar M, Zhou L, Lombardi-Coronel I, Mandala I, Adam MA, Wang S, Bi Q, Hoekman MFM, Li J, Kriegstein AR
Nature communications 2025 Jul 1;16(1):5925

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m(6)A/YTHDF2-mediated mRNA decay targets TGF-β signaling to suppress the quiescence acquisition of early postnatal mouse hippocampal NSCs.

Zhang F, Fu Y, Jimenez-Cyrus D, Zhao T, Shen Y, Sun Y, Zhang Z, Wang Q, Kawaguchi R, Geschwind DH, He C, Ming GL, Song H
Cell stem cell 2025 Jan 2;32(1):144-156.e8

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Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells.

Wang M, Chen R, Wang Y, Li Y, Zhou Q, Cao R, Li Y, Ge H, Wang X, Yang L
Investigative ophthalmology & visual science 2025 Apr 1;66(4):55

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Inhalation of nicotine-containing electronic cigarette vapor exacerbates the features of COPD by inducing ferroptosis in βENaC-overexpressing mice.

Han H, Meister M, Peng G, Yuan Y, Qiao J, Yang JJ, Liu ZR, Ji X
Frontiers in immunology 2024;15:1429946

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Aging of alveolar type 2 cells induced by Lonp1 deficiency exacerbates pulmonary fibrosis.

Zhu W, Tan C, Zhang J
Biomolecules & biomedicine 2024 Sep 6;24(5):1258-1272

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Oxygen-induced stress reveals context-specific gene regulatory effects in human brain organoids.

Umans BD, Gilad Y
bioRxiv : the preprint server for biology 2024 Sep 3;

---

Optimized administration of human embryonic stem cell-derived immunity-and-matrix regulatory cells for mouse lung injury and fibrosis.

Song D, Li Z, Sun F, Wu K, Zhang K, Liu W, Liu K, An B, Wang Z, Zhao T, Chen H, Xiao L, Wang L, Xie L, Li W, Peng L, Hao J, Wu J, Dai H
Stem cell research & therapy 2024 Oct 8;15(1):344

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TRβ activation confers AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPA.

Pan X, Wang L, Yang J, Li Y, Xu M, Liang C, Liu L, Li Z, Xia C, Pang J, Wang M, Li M, Guo S, Yan P, Ding C, Rosas IO, Yu G
Nature communications 2024 Oct 7;15(1):8672

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A cell fate decision map reveals abundant direct neurogenesis bypassing intermediate progenitors in the human developing neocortex.

Coquand L, Brunet Avalos C, Macé AS, Farcy S, Di Cicco A, Lampic M, Wimmer R, Bessières B, Attie-Bitach T, Fraisier V, Sens P, Guimiot F, Brault JB, Baffet AD
Nature cell biology 2024 May;26(5):698-709

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Spatiotemporal dynamics exhibited by horizontal basal cells reveal a pro-neurogenic pathway during injury-induced olfactory epithelium regeneration.

Louie JD, Barrios-Camacho CM, Bromberg BH, Hintschich CA, Schwob JE
iScience 2024 May 17;27(5):109600

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ERK signaling expands mammalian cortical radial glial cells and extends the neurogenic period.

Sun M, Gao Y, Li Z, Yang L, Liu G, Xu Z, Guo R, You Y, Yang Z
Proceedings of the National Academy of Sciences of the United States of America 2024 Mar 26;121(13):e2314802121

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Molecular cascade reveals sequential milestones underlying hippocampal neural stem cell development into an adult state.

Jimenez-Cyrus D, Adusumilli VS, Stempel MH, Maday S, Ming GL, Song H, Bond AM
Cell reports 2024 Jun 25;43(6):114339

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Gut microbiota modulate CD8(+) T cell immunity in gastric cancer through Butyrate/GPR109A/HOPX.

Yu X, Ou J, Wang L, Li Z, Ren Y, Xie L, Chen Z, Liang J, Shen G, Zou Z, Zhao C, Li G, Hu Y
Gut microbes 2024 Jan-Dec;16(1):2307542

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Lysosomal dynamics regulate mammalian cortical neurogenesis.

Zou W, Lv Y, Zhang S, Li L, Sun L, Jiao J
Developmental cell 2024 Jan 8;59(1):64-78.e5

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BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period.

Li Z, Liu G, Yang L, Sun M, Zhang Z, Xu Z, Gao Y, Jiang X, Su Z, Li X, Yang Z
Protein & cell 2024 Jan 3;15(1):21-35

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Following the p63/Keratin5 basal cells in the sensory and non-sensory epithelia of the vomeronasal organ.

LeFever NM, Katreddi RR, Dolphin NM, Mathias NA, Forni PE
Genesis (New York, N.Y. : 2000) 2024 Apr;62(2):e23596

---

Single cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism.

Perez Y, Velmeshev D, Wang L, White M, Siebert C, Baltazar J, Dutton NG, Wang S, Haeussler M, Chamberlain S, Kriegstein A
bioRxiv : the preprint server for biology 2023 Sep 22;

---

LIF signaling regulates outer radial glial to interneuron fate during human cortical development.

Andrews MG, Siebert C, Wang L, White ML, Ross J, Morales R, Donnay M, Bamfonga G, Mukhtar T, McKinney AA, Gemenes K, Wang S, Bi Q, Crouch EE, Parikshak N, Panagiotakos G, Huang E, Bhaduri A, Kriegstein AR
Cell stem cell 2023 Oct 5;30(10):1382-1391.e5

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Decreased fucosylation impacts epithelial integrity and increases risk for COPD.

Swaby C, Yeung-Luk B, Thapa S, Nishida K, Wally A, Ghosh B, Niederkofler A, Luk S, Girgis M, Keller A, Cortez C, Ramaswamy S, Wilmsen K, Bouché L, Dell A, Drummond MB, Putcha N, Haslam SM, Mathias R, Hansel NN, Sheng J, Sidhaye V
bioRxiv : the preprint server for biology 2023 Nov 2;

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Bacterial TLR2/6 Ligands Block Ciliogenesis, Derepress Hedgehog Signaling, and Expand the Neocortex.

Mann B, Crawford JC, Reddy K, Lott J, Youn YH, Gao G, Guy C, Chou CH, Darnell D, Trivedi S, Bomme P, Loughran AJ, Thomas PG, Han YG, Tuomanen EI
mBio 2023 Jun 27;14(3):e0051023

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Schizophrenia-associated NRXN1 deletions induce developmental-timing- and cell-type-specific vulnerabilities in human brain organoids.

Sebastian R, Jin K, Pavon N, Bansal R, Potter A, Song Y, Babu J, Gabriel R, Sun Y, Aronow B, Pak C
Nature communications 2023 Jun 24;14(1):3770

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HOPX is a tumor-suppressive biomarker that corresponds to T cell infiltration in skin cutaneous melanoma.

He S, Ding Y, Ji Z, Yuan B, Chen J, Ren W
Cancer cell international 2023 Jun 21;23(1):122

---

The transcriptional co-activator Yap1 promotes adult hippocampal neural stem cell activation.

Fan W, Jurado-Arjona J, Alanis-Lobato G, Péron S, Berger C, Andrade-Navarro MA, Falk S, Berninger B
The EMBO journal 2023 Jun 1;42(11):e110384

---

p53 governs an AT1 differentiation programme in lung cancer suppression.

Kaiser AM, Gatto A, Hanson KJ, Zhao RL, Raj N, Ozawa MG, Seoane JA, Bieging-Rolett KT, Wang M, Li I, Trope WL, Liou DZ, Shrager JB, Plevritis SK, Newman AM, Van Rechem C, Attardi LD
Nature 2023 Jul;619(7971):851-859

---

RAGE inhibition alleviates lipopolysaccharides-induced lung injury via directly suppressing autophagic apoptosis of type II alveolar epithelial cells.

Xiong X, Dou J, Shi J, Ren Y, Wang C, Zhang Y, Cui Y
Respiratory research 2023 Jan 24;24(1):24

---

hsa-miR-1301-3p Promotes the Proliferation and Migration of Nonsmall Cell Lung Cancer Cells and Reduces Radiosensitivity via Targeting Homeodomain-Only Protein Homeobox.

Qu M, Jin Z, Xu Y, Sun W, Luo Y, Zhang N, Huang Z, Han L, Gong Y, Xie C
Genetic testing and molecular biomarkers 2023 Dec;27(12):393-405

---

FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells.

Park SHE, Kulkarni A, Konopka G
PLoS biology 2023 Aug;21(8):e3001852

---

Integrated Strategies of Diverse Feature Selection Methods Identify Aging-Based Reliable Gene Signatures for Ischemic Cardiomyopathy.

Song H, Chen S, Zhang T, Huang X, Zhang Q, Li C, Chen C, Chen S, Liu D, Wang J, Tu Y, Wu Y, Liu Y
Frontiers in molecular biosciences 2022;9:805235

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The cortical hem lacks stem cell potential despite expressing SOX9 and HOPX.

Caramello A, Galichet C, Sopena ML, Lovell-Badge R, Rizzoti K
Developmental neurobiology 2022 Oct;82(7-8):565-580

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Imaging three-dimensional brain organoid architecture from meso- to nanoscale across development.

Rodriguez-Gatica JE, Iefremova V, Sokhranyaeva L, Au Yeung SWC, Breitkreuz Y, Brüstle O, Schwarz MK, Kubitscheck U
Development (Cambridge, England) 2022 Oct 15;149(20)

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Developmental Origins of Human Cortical Oligodendrocytes and Astrocytes.

Yang L, Li Z, Liu G, Li X, Yang Z
Neuroscience bulletin 2022 Jan;38(1):47-68

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The human FOXM1 homolog promotes basal progenitor cell proliferation and cortical folding in mouse.

Wang W, Su L, Ji F, Zhang D, Wang Y, Zhao J, Jiao RD, Zhang M, Huang E, Jiang H, Zhang J, Jiao J
EMBO reports 2022 Feb 3;23(3):e53602

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Human alveolar progenitors generate dual lineage bronchioalveolar organoids.

Hoffmann K, Obermayer B, Hönzke K, Fatykhova D, Demir Z, Löwa A, Alves LGT, Wyler E, Lopez-Rodriguez E, Mieth M, Baumgardt M, Hoppe J, Firsching TC, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Gruber AD, Ochs M, Landthaler M, Beule D, Suttorp N, Hippenstiel S, Hocke AC, Kessler M
Communications biology 2022 Aug 25;5(1):875

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RGC-32 Acts as a Hub to Regulate the Transcriptomic Changes Associated With Astrocyte Development and Reactive Astrocytosis.

Tatomir A, Beltrand A, Nguyen V, Courneya JP, Boodhoo D, Cudrici C, Muresanu DF, Rus V, Badea TC, Rus H
Frontiers in immunology 2021;12:705308

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Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis.

Cebrian-Silla A, Nascimento MA, Redmond SA, Mansky B, Wu D, Obernier K, Romero Rodriguez R, Gonzalez-Granero S, García-Verdugo JM, Lim DA, Álvarez-Buylla A
eLife 2021 Jul 14;10

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Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes.

Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Perez Y, Mostajo-Radji MA, Wang S, Velmeshev D, Salma J, Kumar GR, Pollen AA, Crouch EE, Ott M, Kriegstein AR
bioRxiv : the preprint server for biology 2021 Jan 18;

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HOPX Plays a Critical Role in Antiretroviral Drugs Induced Epigenetic Modification and Cardiac Hypertrophy.

Kashyap S, Rabbani M, de Lima I, Kondrachuk O, Patel R, Shafiei MS, Mukker A, Rajakumar A, Gupta MK
Cells 2021 Dec 8;10(12)

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Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia.

Eze UC, Bhaduri A, Haeussler M, Nowakowski TJ, Kriegstein AR
Nature neuroscience 2021 Apr;24(4):584-594

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mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex.

Andrews MG, Subramanian L, Kriegstein AR
eLife 2020 Sep 2;9

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YAP1/TAZ drives ependymoma-like tumour formation in mice.

Eder N, Roncaroli F, Domart MC, Horswell S, Andreiuolo F, Flynn HR, Lopes AT, Claxton S, Kilday JP, Collinson L, Mao JH, Pietsch T, Thompson B, Snijders AP, Ultanir SK
Nature communications 2020 May 13;11(1):2380

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Cell stress in cortical organoids impairs molecular subtype specification.

Bhaduri A, Andrews MG, Mancia Leon W, Jung D, Shin D, Allen D, Jung D, Schmunk G, Haeussler M, Salma J, Pollen AA, Nowakowski TJ, Kriegstein AR
Nature 2020 Feb;578(7793):142-148

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Origins and Proliferative States of Human Oligodendrocyte Precursor Cells.

Huang W, Bhaduri A, Velmeshev D, Wang S, Wang L, Rottkamp CA, Alvarez-Buylla A, Rowitch DH, Kriegstein AR
Cell 2020 Aug 6;182(3):594-608.e11

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Assessment of radial glia in the frontal lobe of fetuses with Down syndrome.

Baburamani AA, Vontell RT, Uus A, Pietsch M, Patkee PA, Wyatt-Ashmead J, Chin-Smith EC, Supramaniam VG, Donald Tournier J, Deprez M, Rutherford MA
Acta neuropathologica communications 2020 Aug 20;8(1):141

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Primary Ciliary Deficits in the Dentate Gyrus of Fragile X Syndrome.

Lee B, Panda S, Lee HY
Stem cell reports 2020 Aug 11;15(2):454-466

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Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.

LaFave LM, Kartha VK, Ma S, Meli K, Del Priore I, Lareau C, Naranjo S, Westcott PMK, Duarte FM, Sankar V, Chiang Z, Brack A, Law T, Hauck H, Okimoto A, Regev A, Buenrostro JD, Jacks T
Cancer cell 2020 Aug 10;38(2):212-228.e13

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Molecular Signatures of a TLR4 Agonist-Adjuvanted HIV-1 Vaccine Candidate in Humans.

Anderson J, Olafsdottir TA, Kratochvil S, McKay PF, Östensson M, Persson J, Shattock RJ, Harandi AM
Frontiers in immunology 2018;9:301

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Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis.

Cheung WK, Zhao M, Liu Z, Stevens LE, Cao PD, Fang JE, Westbrook TF, Nguyen DX
Cancer cell 2013 Jun 10;23(6):725-38

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse lung tissue were subjected to SDS PAGE followed by western blot with 11419-1-AP(HOPX antibody) at dilution of 1:200

Sample type

tissue

Immunoprecipitation

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

IP result of HOPX antibody (11419-1-AP for IP and Detection) with mouse lung tissue lysate.

Sample type

tissue