HPA030180

antibody from Atlas Antibodies

Targeting: HOPX HOP, LAGY, NECC1, OB1, SMAP31

Provider product page for HPA030180

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [26]
Comments [0]
Validations
Immunohistochemistry [1]

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Product number: HPA030180 - Provider product page
Provider: Atlas Antibodies
Proper citation: Atlas Antibodies Cat#HPA030180, RRID:AB_10603770
Product name: Anti-HOPX
Antibody type: Polyclonal
Description: Polyclonal Antibody against Human HOPX, Gene description: HOP homeobox, Alternative Gene Names: HOP, LAGY, NECC1, OB1, SMAP31, Validated applications: IHC, Uniprot ID: Q9BPY8, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µl
Concentration: 0.3 mg/ml
Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling: The antibody solution should be gently mixed before use.

HOPX protein structure - HPA030180 shown in red.

Submitted references Protocol for generating human cortical organoids enriched in outer radial glia by guided differentiation

Luongo R, Walsh R, Verrillo A, Studer L, Baggiolini A
STAR Protocols 2024;5(3):103280

Generation of human cerebral organoids with a structured outer subventricular zone

Walsh R, Luongo R, Giacomelli E, Ciceri G, Rittenhouse C, Verrillo A, Galimberti M, Bocchi V, Wu Y, Xu N, Mosole S, Muller J, Vezzoli E, Jungverdorben J, Zhou T, Barker R, Cattaneo E, Studer L, Baggiolini A
Cell Reports 2024;43(4):114031

PRDM16 co-operates with LHX2 to shape the human brain

Suresh V, Bhattacharya B, Tshuva R, Danan Gotthold M, Olender T, Bose M, Pradhan S, Zeev B, Smith R, Tole S, Galande S, Harwell C, Baizabal J, Reiner O
Oxford Open Neuroscience 2024;3

Glycogen Synthase Kinase-3 Inhibition by CHIR99021 Promotes Alveolar Epithelial Cell Proliferation and Lung Regeneration in the Lipopolysaccharide-Induced Acute Lung Injury Mouse Model

Fernandes R, Barbosa-Matos C, Borges-Pereira C, Carvalho A, Costa S
International Journal of Molecular Sciences 2024;25(2):1279

Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury states

Tan J, Zhu R, Dai S, Yao J, Zhao Q, Yin Y, Sun J, Du X, Ge L, Xu J, Hou C, Li N, Li J, Ji W, Zhu C, Zhang R, Li T
eLife 2024;12

An integrated single-cell analysis of human adrenal cortex development

del Valle I, Young M, Kildisiute G, Ogunbiyi O, Buonocore F, Simcock I, Khabirova E, Crespo B, Moreno N, Brooks T, Niola P, Swarbrick K, Suntharalingham J, McGlacken-Byrne S, Arthurs O, Behjati S, Achermann J
JCI Insight 2023;8(14)

The HOPX and BLBP landscape and gliogenic regions in developing human brain

Holst C, Brøchner C, Vitting‐Seerup K, Møllgård K
Journal of Anatomy 2023;243(1):23-38

Purification and characterization of human neural stem and progenitor cells

Liu D, He J, Sinha R, Eastman A, Toland A, Morri M, Neff N, Vogel H, Uchida N, Weissman I
Cell 2023;186(6):1179-1194.e15

Early postnatal defects in neurogenesis in the 3xTg mouse model of Alzheimer’s disease

Liu Y, Bilen M, McNicoll M, Harris R, Fong B, Iqbal M, Paul S, Mayne J, Walker K, Wang J, Figeys D, Slack R
Cell Death & Disease 2023;14(2)

BRN2 as a key gene drives the early primate telencephalon development

Zhu X, Guo Y, Chu C, Liu D, Duan K, Yin Y, Si C, Kang Y, Yao J, Du X, Li J, Zhao S, Ai Z, Zhu Q, Ji W, Niu Y, Li T
Science Advances 2022;8(9)

FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells

Jones M, Lingampally A, Ahmadvand N, Chong L, Wu J, Wilhem J, Vazquez-Armendariz A, Ansari M, Herold S, Ornitz D, Schiller H, Chao C, Zhang J, Carraro G, Bellusci S
Cellular and Molecular Life Sciences 2022;79(12)

Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing

Zhao Z, Zhang D, Yang F, Xu M, Zhao S, Pan T, Liu C, Liu Y, Wu Q, Tu Q, Zhou P, Li R, Kang J, Zhu L, Gao F, Wang Y, Xu Z
Cell Research 2022;32(5):425-436

Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells

Rosebrock D, Arora S, Mutukula N, Volkman R, Gralinska E, Balaskas A, Aragonés Hernández A, Buschow R, Brändl B, Müller F, Arndt P, Vingron M, Elkabetz Y
Nature Cell Biology 2022;24(6):981-995

Human‐specific ARHGAP11B ensures human‐like basal progenitor levels in hominid cerebral organoids

Fischer J, Fernández Ortuño E, Marsoner F, Artioli A, Peters J, Namba T, Eugster Oegema C, Huttner W, Ladewig J, Heide M
EMBO reports 2022;23(11)

H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion

Kerimoglu C, Pham L, Tonchev A, Sakib M, Xie Y, Sokpor G, Ulmke P, Kaurani L, Abbas E, Nguyen H, Rosenbusch J, Michurina A, Capece V, Angelova M, Maricic N, Brand-Saberi B, Esgleas M, Albert M, Minkov R, Kovachev E, Teichmann U, Seong R, Huttner W, Nguyen H, Stoykova A, Staiger J, Fischer A, Tuoc T
Science Advances 2021;7(38)

TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a

Hou Q, Xiao Q, Sun X, Ju X, Luo Z
Science Advances 2021;7(3)

Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation

Liang D, Elwell A, Aygün N, Krupa O, Wolter J, Kyere F, Lafferty M, Cheek K, Courtney K, Yusupova M, Garrett M, Ashley-Koch A, Crawford G, Love M, de la Torre-Ubieta L, Geschwind D, Stein J
Nature Neuroscience 2021;24(7):941-953

Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity

Kyrousi C, O’Neill A, Brazovskaja A, He Z, Kielkowski P, Coquand L, Di Giaimo R, D’ Andrea P, Belka A, Forero Echeverry A, Mei D, Lenge M, Cruceanu C, Buchsbaum I, Khattak S, Fabien G, Binder E, Elmslie F, Guerrini R, Baffet A, Sieber S, Treutlein B, Robertson S, Cappello S
Nature Communications 2021;12(1)

Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis

Aygün N, Elwell A, Liang D, Lafferty M, Cheek K, Courtney K, Mory J, Hadden-Ford E, Krupa O, de la Torre-Ubieta L, Geschwind D, Love M, Stein J
The American Journal of Human Genetics 2021;108(9):1647-1668

A discrete subtype of neural progenitor crucial for cortical folding in the gyrencephalic mammalian brain

Matsumoto N, Tanaka S, Horiike T, Shinmyo Y, Kawasaki H
eLife 2020;9

Centrosome anchoring regulates progenitor properties and cortical formation

Shao W, Yang J, He M, Yu X, Lee C, Yang Z, Joyner A, Anderson K, Zhang J, Tsou M, Shi H, Shi S
Nature 2020;580(7801):106-112

Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex

Bendriem R, Singh S, Aleem A, Antonetti D, Ross M
eLife 2019;8

A critical role for miR-142 in alveolar epithelial lineage formation in mouse lung development

Shrestha A, Carraro G, Nottet N, Vazquez-Armendariz A, Herold S, Cordero J, Singh I, Wilhelm J, Barreto G, Morty R, El Agha E, Mari B, Chen C, Zhang J, Chao C, Bellusci S
Cellular and Molecular Life Sciences 2019;76(14):2817-2832

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

Velasco S, Kedaigle A, Simmons S, Nash A, Rocha M, Quadrato G, Paulsen B, Nguyen L, Adiconis X, Regev A, Levin J, Arlotta P
Nature 2019;570(7762):523-527

The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice

Ju X, Hou Q, Sheng A, Wu K, Zhou Y, Jin Y, Wen T, Yang Z, Wang X, Luo Z
eLife 2016;5

Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells

Stadler C, Rexhepaj E, Singan V, Murphy R, Pepperkok R, Uhlén M, Simpson J, Lundberg E
Nature Methods 2013;10(4):315-323

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Supportive validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Orthogonal validation
Main image
Experimental details: Immunohistochemistry analysis in human skin and liver tissues using HPA030180 antibody. Corresponding HOPX RNA-seq data are presented for the same tissues.
Sample type: Human
Protocol: Protocol
Orthogonal method: Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

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