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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [26]
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- Validations
- Immunohistochemistry [1]
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- Product number
- HPA030180 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA030180, RRID:AB_10603770
- Product name
- Anti-HOPX
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human HOPX, Gene description: HOP homeobox, Alternative Gene Names: HOP, LAGY, NECC1, OB1, SMAP31, Validated applications: IHC, Uniprot ID: Q9BPY8, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.3 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Protocol for generating human cortical organoids enriched in outer radial glia by guided differentiation
Generation of human cerebral organoids with a structured outer subventricular zone
PRDM16 co-operates with LHX2 to shape the human brain
Glycogen Synthase Kinase-3 Inhibition by CHIR99021 Promotes Alveolar Epithelial Cell Proliferation and Lung Regeneration in the Lipopolysaccharide-Induced Acute Lung Injury Mouse Model
Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury states
An integrated single-cell analysis of human adrenal cortex development
The HOPX and BLBP landscape and gliogenic regions in developing human brain
Purification and characterization of human neural stem and progenitor cells
Early postnatal defects in neurogenesis in the 3xTg mouse model of Alzheimer’s disease
BRN2 as a key gene drives the early primate telencephalon development
Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing
Human-specific ARHGAP11B ensures human-like basal progenitor levels in hominid cerebral organoids.
FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells.
Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells.
H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion
TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a
Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation
Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis
Centrosome anchoring regulates progenitor properties and cortical formation
A discrete subtype of neural progenitor crucial for cortical folding in the gyrencephalic mammalian brain.
Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex
Individual brain organoids reproducibly form cell diversity of the human cerebral cortex.
A critical role for miR-142 in alveolar epithelial lineage formation in mouse lung development.
The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice
Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells
Luongo R, Walsh R, Verrillo A, Studer L, Baggiolini A
STAR Protocols 2024;5(3):103280
STAR Protocols 2024;5(3):103280
Generation of human cerebral organoids with a structured outer subventricular zone
Walsh R, Luongo R, Giacomelli E, Ciceri G, Rittenhouse C, Verrillo A, Galimberti M, Bocchi V, Wu Y, Xu N, Mosole S, Muller J, Vezzoli E, Jungverdorben J, Zhou T, Barker R, Cattaneo E, Studer L, Baggiolini A
Cell Reports 2024;43(4):114031
Cell Reports 2024;43(4):114031
PRDM16 co-operates with LHX2 to shape the human brain
Suresh V, Bhattacharya B, Tshuva R, Danan Gotthold M, Olender T, Bose M, Pradhan S, Zeev B, Smith R, Tole S, Galande S, Harwell C, Baizabal J, Reiner O
Oxford Open Neuroscience 2024;3
Oxford Open Neuroscience 2024;3
Glycogen Synthase Kinase-3 Inhibition by CHIR99021 Promotes Alveolar Epithelial Cell Proliferation and Lung Regeneration in the Lipopolysaccharide-Induced Acute Lung Injury Mouse Model
Fernandes R, Barbosa-Matos C, Borges-Pereira C, Carvalho A, Costa S
International Journal of Molecular Sciences 2024;25(2):1279
International Journal of Molecular Sciences 2024;25(2):1279
Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury states
Tan J, Zhu R, Dai S, Yao J, Zhao Q, Yin Y, Sun J, Du X, Ge L, Xu J, Hou C, Li N, Li J, Ji W, Zhu C, Zhang R, Li T
eLife 2024;12
eLife 2024;12
An integrated single-cell analysis of human adrenal cortex development
del Valle I, Young M, Kildisiute G, Ogunbiyi O, Buonocore F, Simcock I, Khabirova E, Crespo B, Moreno N, Brooks T, Niola P, Swarbrick K, Suntharalingham J, McGlacken-Byrne S, Arthurs O, Behjati S, Achermann J
JCI Insight 2023;8(14)
JCI Insight 2023;8(14)
The HOPX and BLBP landscape and gliogenic regions in developing human brain
Holst C, Brøchner C, Vitting‐Seerup K, Møllgård K
Journal of Anatomy 2023;243(1):23-38
Journal of Anatomy 2023;243(1):23-38
Purification and characterization of human neural stem and progenitor cells
Liu D, He J, Sinha R, Eastman A, Toland A, Morri M, Neff N, Vogel H, Uchida N, Weissman I
Cell 2023;186(6):1179-1194.e15
Cell 2023;186(6):1179-1194.e15
Early postnatal defects in neurogenesis in the 3xTg mouse model of Alzheimer’s disease
Liu Y, Bilen M, McNicoll M, Harris R, Fong B, Iqbal M, Paul S, Mayne J, Walker K, Wang J, Figeys D, Slack R
Cell Death & Disease 2023;14(2)
Cell Death & Disease 2023;14(2)
BRN2 as a key gene drives the early primate telencephalon development
Zhu X, Guo Y, Chu C, Liu D, Duan K, Yin Y, Si C, Kang Y, Yao J, Du X, Li J, Zhao S, Ai Z, Zhu Q, Ji W, Niu Y, Li T
Science Advances 2022;8(9)
Science Advances 2022;8(9)
Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing
Zhao Z, Zhang D, Yang F, Xu M, Zhao S, Pan T, Liu C, Liu Y, Wu Q, Tu Q, Zhou P, Li R, Kang J, Zhu L, Gao F, Wang Y, Xu Z
Cell Research 2022;32(5):425-436
Cell Research 2022;32(5):425-436
Human-specific ARHGAP11B ensures human-like basal progenitor levels in hominid cerebral organoids.
Fischer J, Fernández Ortuño E, Marsoner F, Artioli A, Peters J, Namba T, Eugster Oegema C, Huttner WB, Ladewig J, Heide M
EMBO reports 2022 Nov 7;23(11):e54728
EMBO reports 2022 Nov 7;23(11):e54728
FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells.
Jones MR, Lingampally A, Ahmadvand N, Chong L, Wu J, Wilhem J, Vazquez-Armendariz AI, Ansari M, Herold S, Ornitz DM, Schiller HB, Chao CM, Zhang JS, Carraro G, Bellusci S
Cellular and molecular life sciences : CMLS 2022 Nov 29;79(12):609
Cellular and molecular life sciences : CMLS 2022 Nov 29;79(12):609
Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells.
Rosebrock D, Arora S, Mutukula N, Volkman R, Gralinska E, Balaskas A, Aragonés Hernández A, Buschow R, Brändl B, Müller FJ, Arndt PF, Vingron M, Elkabetz Y
Nature cell biology 2022 Jun;24(6):981-995
Nature cell biology 2022 Jun;24(6):981-995
H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion
Kerimoglu C, Pham L, Tonchev A, Sakib M, Xie Y, Sokpor G, Ulmke P, Kaurani L, Abbas E, Nguyen H, Rosenbusch J, Michurina A, Capece V, Angelova M, Maricic N, Brand-Saberi B, Esgleas M, Albert M, Minkov R, Kovachev E, Teichmann U, Seong R, Huttner W, Nguyen H, Stoykova A, Staiger J, Fischer A, Tuoc T
Science Advances 2021;7(38)
Science Advances 2021;7(38)
TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a
Hou Q, Xiao Q, Sun X, Ju X, Luo Z
Science Advances 2021;7(3)
Science Advances 2021;7(3)
Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation
Liang D, Elwell A, Aygün N, Krupa O, Wolter J, Kyere F, Lafferty M, Cheek K, Courtney K, Yusupova M, Garrett M, Ashley-Koch A, Crawford G, Love M, de la Torre-Ubieta L, Geschwind D, Stein J
Nature Neuroscience 2021;24(7):941-953
Nature Neuroscience 2021;24(7):941-953
Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
Kyrousi C, O’Neill A, Brazovskaja A, He Z, Kielkowski P, Coquand L, Di Giaimo R, D’ Andrea P, Belka A, Forero Echeverry A, Mei D, Lenge M, Cruceanu C, Buchsbaum I, Khattak S, Fabien G, Binder E, Elmslie F, Guerrini R, Baffet A, Sieber S, Treutlein B, Robertson S, Cappello S
Nature Communications 2021;12(1)
Nature Communications 2021;12(1)
Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis
Aygün N, Elwell A, Liang D, Lafferty M, Cheek K, Courtney K, Mory J, Hadden-Ford E, Krupa O, de la Torre-Ubieta L, Geschwind D, Love M, Stein J
The American Journal of Human Genetics 2021;108(9):1647-1668
The American Journal of Human Genetics 2021;108(9):1647-1668
Centrosome anchoring regulates progenitor properties and cortical formation
Shao W, Yang J, He M, Yu X, Lee C, Yang Z, Joyner A, Anderson K, Zhang J, Tsou M, Shi H, Shi S
Nature 2020;580(7801):106-112
Nature 2020;580(7801):106-112
A discrete subtype of neural progenitor crucial for cortical folding in the gyrencephalic mammalian brain.
Matsumoto N, Tanaka S, Horiike T, Shinmyo Y, Kawasaki H
eLife 2020 Apr 21;9
eLife 2020 Apr 21;9
Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex
Bendriem R, Singh S, Aleem A, Antonetti D, Ross M
eLife 2019;8
eLife 2019;8
Individual brain organoids reproducibly form cell diversity of the human cerebral cortex.
Velasco S, Kedaigle AJ, Simmons SK, Nash A, Rocha M, Quadrato G, Paulsen B, Nguyen L, Adiconis X, Regev A, Levin JZ, Arlotta P
Nature 2019 Jun;570(7762):523-527
Nature 2019 Jun;570(7762):523-527
A critical role for miR-142 in alveolar epithelial lineage formation in mouse lung development.
Shrestha A, Carraro G, Nottet N, Vazquez-Armendariz AI, Herold S, Cordero J, Singh I, Wilhelm J, Barreto G, Morty R, El Agha E, Mari B, Chen C, Zhang JS, Chao CM, Bellusci S
Cellular and molecular life sciences : CMLS 2019 Jul;76(14):2817-2832
Cellular and molecular life sciences : CMLS 2019 Jul;76(14):2817-2832
The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice
Ju X, Hou Q, Sheng A, Wu K, Zhou Y, Jin Y, Wen T, Yang Z, Wang X, Luo Z
eLife 2016;5
eLife 2016;5
Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells
Stadler C, Rexhepaj E, Singan V, Murphy R, Pepperkok R, Uhlén M, Simpson J, Lundberg E
Nature Methods 2013;10(4):315-323
Nature Methods 2013;10(4):315-323
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Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human skin and liver tissues using HPA030180 antibody. Corresponding HOPX RNA-seq data are presented for the same tissues.
- Sample type
- Human
- Protocol
- Protocol
