17670-1-AP

antibody from Proteintech Group

Targeting: JAK2 JTK10

Provider product page for 17670-1-AP

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Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [109]
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Product number: 17670-1-AP - Provider product page
Provider: Proteintech Group
Product name: JAK2 antibody
Antibody type: Polyclonal
Description: KD/KO validated JAK2 antibody (Cat. #17670-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

JAK2 protein structure - 17670-1-AP shown in red.

Submitted references Long non‑coding RNA NKILA regulates the JAK2/STAT3 pathway to exacerbate TGF‑β1‑mediated renal fibrosis.

Han Y, Yang S, Zhang J, Wang Y, Zhao X, Liu H
Molecular medicine reports 2026 May;33(5)

SAR317461 Inhibit JAK2/STAT3 Phosphorylation for Enhanced Anti-leukemia Activity.

Yang XY, Wang Y, Zhang L, Pang SL, Li XJ, Wang PP, Ma RJ, Ma YY, Song CG
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion 2026 Mar;42(2):530-541

TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease.

Tian Y, Liu Y, Feng X, Wu L, Song W, Zhao T, Liu J, Miao X, Ma H, Jia B, Kang L, Liu Q, Zhang W, Guo H, Yang L, Xu J, Liu S
Cell death discovery 2026 Mar 7;12(1)

Anti-inflammatory effects and mechanisms of Podophyllum hexandrum rhizomes and fruits in a chronic pelvic inflammatory disease rat model.

Zhang B, Yang AT, Wang LN, Yu Q, Tan CC, Chao WH, Geng HY, Pei TX, Zhang L, Cao SJ, Qiu F, Kang N
Journal of ethnopharmacology 2026 Feb 28;357:120954

Sea buckthorn flavonoids attenuate oxidative stress in hepatocellular carcinoma via suppression of PI3K/Akt and JAK pathways.

Zhang H, Huang H, Miao F, Nan J
American journal of translational research 2025;17(12):9830-9845

Exploring the therapeutic potential and in vitro validation of baicalin for the treatment of triple-negative breast cancer.

Ma Y, Pan Y, Zhao Q, Zhang C, He H, Pan L, Jia J, Shi A, Yang Y, Zhang W
Frontiers in pharmacology 2025;16:1530056

JAK2/ULK1 axis promotes cervical cancer progression by autophagy induction and SRPK1 phosphorylation.

Duan Q, Wang W, Xiong H, Xiao J, Xiao H, Zhu F, Lu H
Oncogene 2025 Mar;44(9):587-600

MicroRNA-204-5p Deficiency within the vmPFC Region Contributes to Neuroinflammation and Behavioral Disorders via the JAK2/STAT3 Signaling Pathway in Rats.

Chen X, Gan Y, Zhang K, Wu Y, Li Y, Lan T, Zhuang X, Chen S, Yu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2403080

NCAPD3-mediated AKT activation regulates prostate cancer progression.

Zhang Y, Xie W, Zong X, Fang Y, Ren J, Jing Z, Wei Y, Lu S, Zhu Q, Liu P
FASEB bioAdvances 2025 Feb;7(2):e1488

Single-Cell Transcriptomics Reveals ITGA2-Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis.

Zhan ZJ, Li N, Sun Y, Chen L, Yin JD, Shan YH, Zeng JX, Li ZC, Tan HL, Tang N, Chang S, Huang P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e04088

Oxalate stimulates macrophage secretion of prostaglandin E2 to promote renal tubular epithelial cell osteogenesis.

Song Q, Chen X, Jiang Q, He Z, Su X, Dong C, Xiang H, Song C, Xiong Y, Yang S
Life sciences 2025 Apr 1;366-367:123476

Quercetin of huoxuehuayu tongluo decoction and azithromycin combination therapy effectively improves rat tubal factor infertility by inhibiting inflammation.

Shao L, Wang N, Yan Y, Tan Y, Wu Q, Lei L, Wang M, Liu L
Iranian journal of basic medical sciences 2024;27(6):685-694

Dual-Barb Microneedle with JAK/STAT Inhibitor-Loaded Nanovesicles Encapsulation for Tendinopathy.

Chen M, Zou F, Wang P, Hu W, Shen P, Wu X, Xu H, Rui Y, Wang X, Wang Y
Advanced healthcare materials 2024 Nov;13(28):e2401512

Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways.

Yan Y, Bai S, Han H, Dai J, Niu L, Wang H, Dong Q, Yin H, Yuan G, Pan Y
Cell communication and signaling : CCS 2024 May 15;22(1):272

Resveratrol ameliorates glioblastoma inflammatory response by reducing NLRP3 inflammasome activation through inhibition of the JAK2/STAT3 pathway.

Zhang C, Peng Q, Tang Y, Wang C, Wang S, Yu D, Hou S, Wang Y, Zhang L, Lin N
Journal of cancer research and clinical oncology 2024 Mar 28;150(3):168

Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells.

Jing ZL, Liu GL, Zhou N, Xu DY, Feng N, Lei Y, Ma LL, Tang MS, Tong GH, Tang N, Deng YJ
Scientific reports 2024 Mar 13;14(1):6053

Mechanism study of oleanolic acid derivative, K73-03, inducing cell apoptosis in hepatocellular carcinoma.

Wang J, Ma C, Tang Z, Sun Z, Qaed E, Chi X, Wang J, Jamalat Y, Geng Z, Tang Z, Yao Q
Cancer cell international 2024 Jan 7;24(1):17

S100A8/A9 promotes endometrial fibrosis via regulating RAGE/JAK2/STAT3 signaling pathway.

Xin X, Liu H, Zhang S, Li P, Zhao X, Zhang X, Li S, Wu S, Zhao F, Tan J
Communications biology 2024 Jan 22;7(1):116

Molecular mechanism through which Tripterygium hypoglaucum (Lévl.) Hutch alleviates psoriasis.

Sun Y, Wang J, Hu P, Tang Y, Wang Y, Ye J, Yang X, Yin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Dec;181:117647

Unveiling the immunoregulatory role of interferon-induced transmembrane protein 2 through the JAK/STAT3/PDL1 pathway in gastric cancer.

Liu Y, Liang J, Huang J, Li X, Huang J, Wang J
International immunopharmacology 2024 Dec 5;142(Pt B):113221

Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1(+) Macrophages for Infectious Bone Defect Regeneration.

Wu H, Chen C, Li J, Yu D, Wu X, Huang H, Tang Z, Wu Q, Yan S, Wang N, Wang M, Wei F, Yu Y, Wang D, Shi M, Yue X, Cao P, Zheng Z, Li X, Guo B, Shi L, Guo Z
ACS nano 2024 Dec 31;18(52):35575-35594

Testis-Specific Protein, Y-Encoded-Like 2 Activates JAK2/STAT3 Pathway in Hypothalamic Paraventricular Nucleus to Sustain Hypertension.

Li Y, Xu YF, Chi HL, Yu JY, Gao YN, Li HB, Kang YM, Yu XJ
American journal of hypertension 2024 Aug 14;37(9):682-691

Baicalin reduces inflammation to inhibit lung cancer via targeting SOCS1/NF-κB/STAT3 axis.

Guo L, Yue M, Ma C, Wang Y, Hou J, Li H
Heliyon 2024 Apr 30;10(8):e29361

Combining network pharmacology and in vitro and in vivo experiments to study the mechanism of Keluoxin in the treatment of radiation nephropathy†.

Deng L, Wang S, Leng X, Yao P, Li C, Zheng Y
Journal of radiation research 2023 Sep 22;64(5):769-782

Ulinastatin inhibits the metastasis of nasopharyngeal carcinoma by involving uPA/uPAR signaling.

Li CZ, Qiang YY, Liu ZJ, Zheng LS, Peng LX, Mei Y, Meng DF, Wei WW, Chen DW, Xu L, Lang YH, Xie P, Peng XS, Wang MD, Guo LL, Shu DT, Ding LY, Lin ST, Luo FF, Wang J, Li SS, Huang BJ, Chen JD, Qian CN
Drug development research 2023 Nov;84(7):1468-1481

Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders.

Lun J, Li Y, Gao X, Gong Z, Chen X, Zou J, Zhou C, Huang Y, Zhou B, Huang P, Cao H
Journal of neuroinflammation 2023 Mar 30;20(1):87

Fibroblast growth factor 10 delays the progression of osteoarthritis by attenuating synovial fibrosis via inhibition of IL-6/JAK2/STAT3 signaling in vivo and in vitro.

Su W, Zheng X, Zhou H, Yang S, Zhu X
Molecular immunology 2023 Jul;159:46-57

Extracellular Vesicles from Carcinoma-associated Fibroblasts Promote EMT of Salivary Adenoid Cystic Carcinoma Via IL-6.

Al-Raimi HAI, Kong J, Ran Y, Zhu L, Li J, Liu X, Yang X, Qi D, Liu T
Archives of medical research 2023 Jan;54(1):27-36

α-Asarone alleviates allergic asthma by stabilizing mast cells through inhibition of ERK/JAK2-STAT3 pathway.

Bai H, Xue Z, Zhang W, Feng C, Zhou Z, Hu S, Zhang Y, Qin Q, Wu Y, Sun X, Zhou Y, Wang N
BioFactors (Oxford, England) 2023 Jan;49(1):140-152

Involvement of METTL3 in arsenite-induced skin lesions by targeting the SOCS3/STAT3/Krt signaling pathway.

Yang F, Zhang A
Environmental pollution (Barking, Essex : 1987) 2023 Jan 1;316(Pt 2):120634

Amuc Prevents Liver Inflammation and Oxidative Stress in Mice Challenged with Salmonella Typhimurium.

Song Z, Si X, Zhang X, Chen J, Jia H, He Y, Liu H, Kou Z, Dai Z, Wu Z
The Journal of nutrition 2023 Feb;153(2):532-542

Deregulation of PRDM5 promotes cell proliferation by regulating JAK/STAT signaling pathway through SOCS1 in human lung adenocarcinoma.

Ren Y, Wang Y, Fang L, Ma M, Ge L, Su C, Xin L, He J, Yang J, Liu X
Cancer medicine 2023 Feb;12(4):4568-4578

Spermatogenesis associated serine rich 2 like plays a prognostic factor and therapeutic target in acute myeloid leukemia by regulating the JAK2/STAT3/STAT5 axis.

Li F, Ye W, Yao Y, Wei W, Lin X, Zhuang H, Li C, Li X, Ling Q, Hu C, Huang X, Qian Y, Mao S, Huang J, Lu Y, Jin J
Journal of translational medicine 2023 Feb 11;21(1):115

PDGF-BB-Dependent Neurogenesis Buffers Depressive-Like Behaviors by Inhibition of GABAergic Projection from Medial Septum to Dentate Gyrus.

Li HH, Liu Y, Chen HS, Wang J, Li YK, Zhao Y, Sun R, He JG, Wang F, Chen JG
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Aug;10(22):e2301110

FGFR2 upregulates PAI-1 via JAK2/STAT3 signaling to induce M2 polarization of macrophages in colorectal cancer.

Li Y, Shi Y, Zhang X, Li P, Ma L, Hu P, Xu L, Dai Y, Xia S, Qiu H
Biochimica et biophysica acta. Molecular basis of disease 2023 Apr;1869(4):166665

YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.

Li Z, Teng M, Jiang Y, Zhang L, Luo X, Liao Y, Yang B
Frontiers in immunology 2022;13:857727

Shuxie-1 Decoction Alleviated CUMS -Induced Liver Injury via IL-6/JAK2/STAT3 Signaling.

Zhang M, Wu W, Huang C, Cai T, Zhao N, Liu S, Yang S
Frontiers in pharmacology 2022;13:848355

Oxalate induces the ossification of RTECs by activating the JAK2/STAT3 signaling pathway and participates in the formation of kidney stones.

Song Q, Liao W, He Z, Li D, Dong C, Song C, Yang S
Archives of biochemistry and biophysics 2022 Sep 30;727:109325

Alpha7 Nicotinic Acetylcholine Receptor Antagonists Prevent Meningitic Escherichia coli-Induced Blood-Brain Barrier Disruptions by Targeting the CISH/JAK2/STAT5b Axis.

Gong Z, Gao X, Li Y, Zou J, Lun J, Chen J, Zhou C, He X, Cao H
Biomedicines 2022 Sep 22;10(10)

Environmental exposure to microcystin-LR increases the risks of urinary bladder proliferation and carcinogenesis: Evidence from case control, animal, and in vitro studies.

Pan C, Qin H, Jin H, Chen W, Guo H, Han X
Toxicology 2022 Oct;480:153326

Anti-inflammatory potential of stevia residue extract against uric acid-associated renal injury in mice.

Mehmood A, Althobaiti F, Zhao L, Usman M, Chen X, Alharthi F, Soliman MM, Shah AA, Murtaza MA, Nadeem M, Ranjha MMAN, Wang C
Journal of food biochemistry 2022 Oct;46(10):e14286

Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL-6 trans-signalling.

Huo Y, Yang J, Zheng J, Xu D, Yang M, Tao L, Yao H, Fu X, Yang J, Liu D, Hua R, Zhang J, Sun Y, Hu L, Liu W
Cell proliferation 2022 May;55(5):e13237

Polyethylenimine-coated PLGA nanoparticles containing Angelica sinensis polysaccharide promote dendritic cells activation and associated molecular mechanisms.

Gu P, Cai G, Yang Y, Hu Y, Liu J, Wang D
International journal of biological macromolecules 2022 May 15;207:559-569

CircTCF25 serves as a sponge for miR-206 to support proliferation, migration, and invasion of glioma via the Jak2/p-Stat3/CypB axis.

Yin H, Wang H, Wang M, Yan Y, Dong Q, Li Q, Liu Y, Wang X, Guo T, Niu L, Zhang H, Wang B, Yao X, Yuan G, Pan Y
Molecular carcinogenesis 2022 Jun;61(6):558-571

IRAK2-NF-κB signaling promotes glycolysis-dependent tumor growth in pancreatic cancer.

Yang J, Liu DJ, Zheng JH, He RZ, Xu DP, Yang MW, Yao HF, Fu XL, Yang JY, Huo YM, Tao LY, Hua R, Sun YW, Kong XM, Jiang SH, Liu W
Cellular oncology (Dordrecht, Netherlands) 2022 Jun;45(3):367-379

PRRX1 promotes colorectal cancer stemness and chemoresistance via the JAK2/STAT3 axis by targeting IL-6.

Zhong L, Tan W, Yang Q, Zou Z, Zhou R, Huang Y, Qiu Z, Zheng K, Huang Z
Journal of gastrointestinal oncology 2022 Dec;13(6):2989-3008

4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer.

Wang Y, Lei J, Zhang S, Wang X, Jin J, Liu Y, Gan M, Yuan Y, Sun L, Li X, Han T, Wang JB
Cell death & disease 2022 Dec 27;13(12):1075

JAK-STAT signaling mediates the senescence of cartilage-derived stem/progenitor cells.

Ji T, Chen M, Sun W, Zhang X, Cai H, Wang Y, Xu H
Journal of molecular histology 2022 Aug;53(4):635-643

Inhibition of JAK-STAT Signaling Pathway Alleviates Age-Related Phenotypes in Tendon Stem/Progenitor Cells.

Chen M, Xiao L, Dai G, Lu P, Zhang Y, Li Y, Ni M, Rui Y
Frontiers in cell and developmental biology 2021;9:650250

Trefoil Factor 3 Inhibits Thyroid Cancer Cell Progression Related to IL-6/JAK/STAT3 Signaling Pathway.

Xin Y, Shang X, Sun X, Liu Y, Xu G, Xue G
Evidence-based complementary and alternative medicine : eCAM 2021;2021:2130229

PARP Inhibitor Upregulates PD-L1 Expression and Provides a New Combination Therapy in Pancreatic Cancer.

Wang Y, Zheng K, Xiong H, Huang Y, Chen X, Zhou Y, Qin W, Su J, Chen R, Qiu H, Yuan X, Wang Y, Zou Y
Frontiers in immunology 2021;12:762989

Effects and Molecular Mechanism of Single-Nucleotide Polymorphisms of MEG3 on Porcine Skeletal Muscle Development.

Yang R, Liu Y, Cheng Y, Wang C, Song J, Lu G, Feng T, Wang S, Sun X, Meng J, Hao L
Frontiers in genetics 2021;12:607910

CTR9-mediated JAK2/STAT3 pathway promotes the proliferation, migration, and invasion of human glioma cells.

Xu Y, Chen J, He G, Zhang Y
Journal of clinical laboratory analysis 2021 Sep;35(9):e23943

ST8SIA1 inhibits the proliferation, migration and invasion of bladder cancer cells by blocking the JAK/STAT signaling pathway.

Yu S, Wang S, Sun X, Wu Y, Zhao J, Liu J, Yang D, Jiang Y
Oncology letters 2021 Oct;22(4):736

Chorionic villus-derived mesenchymal stem cell-mediated autophagy promotes the proliferation and invasiveness of trophoblasts under hypoxia by activating the JAK2/STAT3 signalling pathway.

Chu Y, Zhu C, Yue C, Peng W, Chen W, He G, Liu C, Lv Y, Gao G, Yao K, Han R, Hu X, Zhang Y, Ye Y
Cell & bioscience 2021 Oct 13;11(1):182

Src acts as the target of matrine to inhibit the proliferation of cancer cells by regulating phosphorylation signaling pathways.

Zhang X, Xu H, Bi X, Hou G, Liu A, Zhao Y, Wang G, Cao X
Cell death & disease 2021 Oct 12;12(10):931

Study on the effect of Mongolian medicine Qiwei Qinggan Powder on hepatic fibrosis through JAK2/STAT3 pathway.

Liang J, Yuan H, Xu L, Wang F, Bao X, Yan Y, Wang H, Zhang C, Jin R, Ma L, Zhang J, Huri L, Su X, Xiao R, Ma Y
Bioscience, biotechnology, and biochemistry 2021 Mar 24;85(4):775-785

Differential effects of EPA and DHA on DSS-induced colitis in mice and possible mechanisms involved.

Zhang Z, Xue Z, Yang H, Zhao F, Liu C, Chen J, Lu S, Zou Z, Zhou Y, Zhang X
Food & function 2021 Mar 1;12(4):1803-1817

Effect of SOCS3 on apoptosis of human trophoblasts via adjustment of the JAK2/STAT3 signaling pathway in preterm birth.

Yin Y, Qu L, Zhu D, Wu Y, Zhou X
Translational pediatrics 2021 Jun;10(6):1637-1646

A metabolic data-driven systems pharmacology strategy for decoding and validating the mechanism of Compound Kushen Injection against HCC.

Wang KX, Chen YP, Lu AP, Du GH, Qin XM, Guan DG, Gao L
Journal of ethnopharmacology 2021 Jun 28;274:114043

Daphnetin ameliorates acute lung injury in mice with severe acute pancreatitis by inhibiting the JAK2-STAT3 pathway.

Yang S, Song Y, Wang Q, Liu Y, Wu Z, Duan X, Zhang Y, Bi X, Geng Y, Chen S, Zhu C
Scientific reports 2021 Jun 1;11(1):11491

The Protective Effects of Parathyroid Hormone (1-34) on Cartilage and Subchondral Bone Through Down-Regulating JAK2/STAT3 and WNT5A/ROR2 in a Collagenase-Induced Osteoarthritis Mouse Model.

Shao LT, Gou Y, Fang JK, Hu YP, Lian QQ, Yang Z, Zhang YY, Wang YD, Tian FM, Zhang L
Orthopaedic surgery 2021 Jul;13(5):1662-1672

Baicalein Delays H(2)O(2)-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism.

Gao L, Zheng WG, Wu XK, Du GH, Qin XM
ACS chemical neuroscience 2021 Jul 7;12(13):2320-2335

Pro-protein convertase subtilisin/kexin type 9 promotes intestinal tumor development by activating Janus kinase 2/signal transducer and activator of transcription 3/SOCS3 signaling in Apc(Min/+) mice.

Yang K, Zhu J, Luo HH, Yu SW, Wang L
International journal of immunopathology and pharmacology 2021 Jan-Dec;35:20587384211038345

Blockade of JAK2 signaling produces immunomodulatory effect to preserve pancreatic homeostasis in severe acute pancreatitis.

Qiu Z, Xu F, Wang Z, Yang P, Bu Z, Cheng F, Jiang H, Li L, Zhang F
Biochemistry and biophysics reports 2021 Dec;28:101133

A comprehensive genome-wide analysis of long non-coding RNA and mRNA expression profiles of JAK2V617F-positive classical myeloproliferative neoplasms.

Zhou J, Wu H, Guo C, Li B, Zhou LL, Liang AB, Fu JF
Bioengineered 2021 Dec;12(2):10564-10586

Helicobacter pylori induces gastric cancer via down-regulating miR-375 to inhibit dendritic cell maturation.

Zhang Z, Chen S, Fan M, Ruan G, Xi T, Zheng L, Guo L, Ye F, Xing Y
Helicobacter 2021 Aug;26(4):e12813

Mild Hypothermia Attenuates Hepatic Ischemia-Reperfusion Injury through Regulating the JAK2/STAT3-CPT1a-Dependent Fatty Acid β-Oxidation.

Wang W, Hu X, Xia Z, Liu Z, Zhong Z, Lu Z, Liu A, Ye S, Cao Q, Wang Y, Zhu F, Ye Q
Oxidative medicine and cellular longevity 2020;2020:5849794

Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway.

Xiang S, Chen K, Xu L, Wang T, Guo C
Drug design, development and therapy 2020;14:129-143

Selaginellin B induces apoptosis and autophagy in pancreatic cancer cells via the JAK2/STAT3 signaling pathway.

Chu P, Wang S, Zhu X, Yang Y, Li H, Tesfaldet T, Shopit A, Yang Y, Ma X, Peng J, Tang Z, Sun Z
American journal of translational research 2020;12(11):7127-7143

Csf2 Attenuated Sepsis-Induced Acute Kidney Injury by Promoting Alternative Macrophage Transition.

Li Y, Zhai P, Zheng Y, Zhang J, Kellum JA, Peng Z
Frontiers in immunology 2020;11:1415

Combination therapy with ropivacaine-loaded liposomes and nutrient deprivation for simultaneous cancer therapy and cancer pain relief.

Zhang J, Zhu S, Tan Q, Cheng D, Dai Q, Yang Z, Zhang L, Li F, Zuo Y, Dai W, Chen L, Gu E, Xu G, Wei Z, Cao Y, Liu X
Theranostics 2020;10(11):4885-4899

Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.

Kang N, Cao S, Jiang B, Zhang Q, Donkor PO, Zhu Y, Qiu F, Gao X
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885

USP9X promotes the proliferation, invasion and metastasis of liver cancer cells through regulating the JAK2/STAT3 signaling.

Song X, Yang W, Wu C, Han Y, Lu Y
Oncology letters 2020 Sep;20(3):2897-2905

Parathyroid hormone (1-34) ameliorates cartilage degeneration and subchondral bone deterioration in collagenase-induced osteoarthritis model in mice.

Shao LT, Gou Y, Fang JK, Hu YP, Lian QQ, Zhang YY, Wang YD, Tian FM, Zhang L
Bone & joint research 2020 Oct;9(10):675-688

Fucoidan from Fucus vesiculosus attenuates doxorubicin-induced acute cardiotoxicity by regulating JAK2/STAT3-mediated apoptosis and autophagy.

Zhang J, Sun Z, Lin N, Lu W, Huang X, Weng J, Sun S, Zhang C, Yang Q, Zhou G, Guo H, Chi J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110534

SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway.

Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Kapell S, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Connor JH, Douam F, Emili A, Saeed M
bioRxiv : the preprint server for biology 2020 Oct 28;

SUMO4 small interfering RNA attenuates invasion and migration via the JAK2/STAT3 pathway in non-small cell lung cancer cells.

Liang JX, Gao W, Zeng XW, Cheng GP, Cai L, Tao KY, Yang X
Oncology letters 2020 Nov;20(5):225

AQP1 modulates tendon stem/progenitor cells senescence during tendon aging.

Chen M, Li Y, Xiao L, Dai G, Lu P, Wang Y, Rui Y
Cell death & disease 2020 Mar 18;11(3):193

Graphene oxide nanoparticles induce hepatic dysfunction through the regulation of innate immune signaling in zebrafish (Danio rerio).

Xiong G, Deng Y, Liao X, Zhang J, Cheng B, Cao Z, Lu H
Nanotoxicology 2020 Jun;14(5):667-682

Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway.

Dong X, Wu D, Zhang Y, Jia L, Pan X, Sun J, Pan LL
Antioxidants (Basel, Switzerland) 2020 Jun 5;9(6)

Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5.

Zhang Y, Zhou L, Zhang Z, Xu Q, Han X, Zhao Y, Song X, Zhao T, Ye L
Environmental science and pollution research international 2020 Feb;27(4):3837-3848

TSLP Produced by Aspergillus fumigatus-Stimulated DCs Promotes a Th17 Response Through the JAK/STAT Signaling Pathway in Fungal Keratitis.

Han F, Guo H, Wang L, Zhang Y, Sun L, Dai C, Wu X
Investigative ophthalmology & visual science 2020 Dec 1;61(14):24

Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway.

Ren S, Xing Y, Wang C, Jiang F, Liu G, Li Z, Jiang T, Zhu Y, Piao D
The international journal of biochemistry & cell biology 2020 Aug;125:105777

Attenuation of Cardiac Ischaemia-reperfusion Injury by Treatment with Hydrogen-rich Water.

Li X, Li L, Liu X, Wu J, Sun X, Li Z, Geng YJ, Liu F, Zhou Y
Current molecular medicine 2019;19(4):294-302

STIP1 Regulates Proliferation and Migration of Lung Adenocarcinoma Through JAK2/STAT3 Signaling Pathway.

Guo X, Yan Z, Zhang G, Wang X, Pan Y, Huang M
Cancer management and research 2019;11:10061-10072

Berberine Maintains the Neutrophil N1 Phenotype to Reverse Cancer Cell Resistance to Doxorubicin.

Zhang S, Zhou L, Zhang M, Wang Y, Wang M, Du J, Gu W, Kui F, Li J, Geng S, Du G
Frontiers in pharmacology 2019;10:1658

Interleukin-6: Its role and mechanisms in rescuing depression-like behaviors in rat models of depression.

Wang P, Feng YB, Wang L, Li Y, Fan C, Song Q, Yu SY
Brain, behavior, and immunity 2019 Nov;82:106-121

Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells.

Zhang Y, Wang S, Zhao T, Yang L, Guo S, Shi Y, Zhang X, Zhou L, Ye L
Ecotoxicology and environmental safety 2019 Nov 30;184:109611

FGFR2 Promotes Expression of PD-L1 in Colorectal Cancer via the JAK/STAT3 Signaling Pathway.

Li P, Huang T, Zou Q, Liu D, Wang Y, Tan X, Wei Y, Qiu H
Journal of immunology (Baltimore, Md. : 1950) 2019 May 15;202(10):3065-3075

Inhibition of Connexin43 hemichannels with Gap19 protects cerebral ischemia/reperfusion injury via the JAK2/STAT3 pathway in mice.

Chen B, Yang L, Chen J, Chen Y, Zhang L, Wang L, Li X, Li Y, Yu H
Brain research bulletin 2019 Mar;146:124-135

Effect of Konjac Mannan Oligosaccharides on Glucose Homeostasis via the Improvement of Insulin and Leptin Resistance In Vitro and In Vivo.

Zhu D, Yan Q, Li Y, Liu J, Liu H, Jiang Z
Nutrients 2019 Jul 24;11(8)

Toxicological exploration of peptide-based cationic liposomes in siRNA delivery.

Zhu Y, Meng Y, Zhao Y, Zhu J, Xu H, Zhang E, Shi L, Du L, Liu G, Zhang C, Xu X, Kang X, Zhen Y, Zhang S
Colloids and surfaces. B, Biointerfaces 2019 Jul 1;179:66-76

Chemical and genetic inhibition of STAT3 sensitizes hepatocellular carcinoma cells to sorafenib induced cell death.

Xie L, Zeng Y, Dai Z, He W, Ke H, Lin Q, Chen Y, Bu J, Lin D, Zheng M
International journal of biological sciences 2018;14(5):577-585

Triptolide delays disease progression in an adult rat model of polycystic kidney disease through the JAK2-STAT3 pathway.

Jing Y, Wu M, Zhang D, Chen D, Yang M, Mei S, He L, Gu J, Qi N, Fu L, Li L, Mei C
American journal of physiology. Renal physiology 2018 Sep 1;315(3):F479-F486

Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis.

Pan H, Fu C, Huang L, Jiang Y, Deng X, Guo J, Su Z
Marine drugs 2018 Jun 5;16(6)

Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.

Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, Qaed E, Ma X, Peng J, Wang S, Hu M, Tang Z
Journal of cellular physiology 2018 Jan;234(1):777-788

Protocatechuic aldehyde protects against isoproterenol-induced cardiac hypertrophy via inhibition of the JAK2/STAT3 signaling pathway.

Fang X, Liu Y, Lu J, Hong H, Yuan J, Zhang Y, Wang P, Liu P, Ye J
Naunyn-Schmiedeberg's archives of pharmacology 2018 Dec;391(12):1373-1385

CEP55 Promotes Cell Motility via JAK2⁻STAT3⁻MMPs Cascade in Hepatocellular Carcinoma.

Li M, Gao J, Li D, Yin Y
Cells 2018 Aug 8;7(8)

LPS‑induced proinflammatory cytokine expression in human airway epithelial cells and macrophages via NF‑κB, STAT3 or AP‑1 activation.

Liu X, Yin S, Chen Y, Wu Y, Zheng W, Dong H, Bai Y, Qin Y, Li J, Feng S, Zhao P
Molecular medicine reports 2018 Apr;17(4):5484-5491

Effects of apigenin pretreatment against renal ischemia/reperfusion injury via activation of the JAK2/STAT3 pathway.

Liu Y, Wang L, Du Y, Chen Z, Guo J, Weng X, Wang X, Wang M, Chen D, Liu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:1799-1808

Effect of modified Xiaochaihu decoction‑containing serum on HepG2.2.15 cells via the JAK2/STAT3 signaling pathway.

Chen S, Wang Z, Wan S, Huang H, Liang H
Molecular medicine reports 2017 Nov;16(5):7416-7422

Propofol enhances the cisplatin-induced apoptosis on cervical cancer cells via EGFR/JAK2/STAT3 pathway.

Li H, Lu Y, Pang Y, Li M, Cheng X, Chen J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Feb;86:324-333

Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.

Song Y, Kong L, Sun B, Gao L, Chu P, Ahsan A, Qaed E, Lin Y, Peng J, Ma X, Zhang J, Wang S, Tang Z
Cell biology international 2017 Dec;41(12):1367-1378

IL-6 promotes epithelial-to-mesenchymal transition of human peritoneal mesothelial cells possibly through the JAK2/STAT3 signaling pathway.

Xiao J, Gong Y, Chen Y, Yu D, Wang X, Zhang X, Dou Y, Liu D, Cheng G, Lu S, Yuan W, Li Y, Zhao Z
American journal of physiology. Renal physiology 2017 Aug 1;313(2):F310-F318

Oral kanglaite injection (KLTI) attenuates the lung cancer-promoting effect of high-fat diet (HFD)-induced obesity.

Cao N, Ma X, Guo Z, Zheng Y, Geng S, Meng M, Du Z, Lin H, Duan Y, Du G
Oncotarget 2016 Sep 20;7(38):61093-61106

The salicylanilide derivatives inhibit signal transducer and activator of transcription 3 pathways in A549 lung cancer cells.

Hu M, Ye W, Li J, Zhou P, Chu Z, Huang W
Anti-cancer drugs 2016 Jan;27(1):41-7

Paper-based microreactor array for rapid screening of cell signaling cascades.

Huang CH, Lei KF, Tsang NM
Lab on a chip 2016 Aug 7;16(15):2911-20

Exogenous spermine ameliorates high glucose-induced cardiomyocytic apoptosis via decreasing reactive oxygen species accumulation through inhibiting p38/JNK and JAK2 pathways.

He Y, Yang J, Li H, Shao H, Wei C, Wang Y, Li M, Xu C
International journal of clinical and experimental pathology 2015;8(12):15537-49

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The JAK2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human JAK2. This antibody recognizes human,mouse,rat antigen. The JAK2 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 17670-1-AP.pdf

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