ABIN319310

antibody from antibodies-online

Targeting: JAK2 JTK10

Western blot (Recommended by provider)

Antibody Data

Product number

ABIN319310

Provider

antibodies-online

Product name

anti-Janus Kinase 2 (JAK2) (Tyr1007) antibody

Antibody type

Polyclonal

Description

Immunoaffinity Chromatography.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

Tyr1007

Vial size

50 μL

Storage

Store the antibody (in aliquots) at-20°C.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.

James C, Ugo V, Le Couédic JP, Staerk J, Delhommeau F, Lacout C, Garçon L, Raslova H, Berger R, Bennaceur-Griscelli A, Villeval JL, Constantinescu SN, Casadevall N, Vainchenker W
Nature 2005 Apr 28;434(7037):1144-8

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Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity.

Argetsinger LS, Kouadio JL, Steen H, Stensballe A, Jensen ON, Carter-Su C
Molecular and cellular biology 2004 Jun;24(11):4955-67

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Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

Ungureanu D, Saharinen P, Junttila I, Hilton DJ, Silvennoinen O
Molecular and cellular biology 2002 May;22(10):3316-26

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Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation.

Xie S, Wang Y, Liu J, Sun T, Wilson MB, Smithgall TE, Arlinghaus RB
Oncogene 2001 Sep 27;20(43):6188-95