53-9778-80
antibody from Invitrogen Antibodies
Targeting: LAMP5
BAD-LAMP, C20orf103, dJ1119D9.3, UNC-46
Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations [0]
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- Product number
- 53-9778-80 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Anti-LAMP5 (BAD-LAMP) Monoclonal Antibody (34.2), Alexa Fluor 488, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The monoclonal antibody 34.2 recognizes human lysosome-associated membrane protein 5 (LAMP5), a member of the LAMP family. LAMP5 differs from other LAMP family members in that its expression is more restricted and is referred to as brain and dendritic cell-associated LAMP-like molecule (BAD-LAMP). In humans, BAD-LAMP is expressed in post-natal neurons and non-activated plasmacytoid dendritic cells. Expression in neurons is localized to intracellular vesicles distributed in specific microdomains along neurites and may play a role in endocytosis. BAD-LAMP is localized to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) of plasmacytoid dendritic cells and is lost upon TLR activation. Applications Reported: This 34.2 antibody has been reported for use in immunohistochemical staining, and immunohistochemical staining of formalin-fixed paraffin embedded tissue sections. Applications Tested: This 34.2 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using low pH antigen retrieval and can be used at less than or equal to 20 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser. Filtration: 0.2 µm post-manufacturing filtered.
- Reactivity
- Human
- Host
- Rat
- Conjugate
- Green dye
- Isotype
- IgG
- Antibody clone number
- 34.2
- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- 4° C, store in dark, DO NOT FREEZE!
Submitted references BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells.
Combes A, Camosseto V, N'Guessan P, Argüello RJ, Mussard J, Caux C, Bendriss-Vermare N, Pierre P, Gatti E
Nature communications 2017 Oct 13;8(1):913
Nature communications 2017 Oct 13;8(1):913
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