PPEF1

This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. [provided by RefSeq, Jul 2008]

Description

Protein phosphatase with EF-hand domain 1

Tissue specificity

Group enriched (brain, testis)

Subcell location

Plasma membrane, Cytokinetic bridge

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

X (18675909 - 18827921)

Ensembl ID

ENSG00000086717  (ver. 103.38)

Orthologs

Mouse Ppef1: ENSMUSG00000062168

UniProt

O14829

neXtProt

NX_O14829

Human splice variants
Mouse splice variants

Protein structure