BS8696
antibody from Bioworld Technology, Inc
Targeting: ICOSLG
B7-H2, B7h, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, KIAA0653
Antibody data
- Antibody Data
- Antigen structure
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- Comments [0]
- Validations [0]
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- Product number
- BS8696 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- ICOSLG polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- ICOS ligand; B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD275; ICOSLG; B7H2, B7RP1, ICOSL, KIAA0653
- Description
- T cell costimulatory molecule, inducible costimulator (ICOS)/B7-related protein-1 (B7RP-1, B7-H2, GL50, ICOS-L) is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. B7RP-1 interactions play an essential role in T cell dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. B7RP-1 protein is present in myeloid leukocytes and by Northern blot there are 2.4, 3.0 and 7.0 kb transcripts in brain, heart, kidney and liver, with lower expression in colon and thymus and a 1.1 kb transcript in leukocytes. Tumor necrosis factor ? (TNF?), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4) enhance B7RP-1 expression. LPS induced up regulation of B7RP-1 is dependent on the MyD88 dependent signaling pathway.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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