Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 12584-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12584-1-AP, RRID:AB_2201672
- Product name
- THAP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated THAP1 antibody (Cat. #12584-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references DYT6 mutated THAP1 is a cell type dependent regulator of the SP1 family.
The dystonia gene THAP1 controls DNA double-strand break repair choice.
Unraveling Molecular Mechanisms of THAP1 Missense Mutations in DYT6 Dystonia.
The DYT6 Dystonia Protein THAP1 Regulates Myelination within the Oligodendrocyte Lineage.
Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia.
Abnormalities of motor function, transcription and cerebellar structure in mouse models of THAP1 dystonia.
Dystonia type 6 gene product Thap1: identification of a 50 kDa DNA-binding species in neuronal nuclear fractions.
Stress-induced changes in gene interactions in human cells.
Neural expression of the transcription factor THAP1 during development in rat.
The dystonia gene DYT1 is repressed by the transcription factor THAP1 (DYT6).
Direct interaction between causative genes of DYT1 and DYT6 primary dystonia.
Cheng F, Zheng W, Barbuti PA, Bonsi P, Liu C, Casadei N, Ponterio G, Meringolo M, Admard J, Dording CM, Yu-Taeger L, Nguyen HP, Grundmann-Hauser K, Ott T, Houlden H, Pisani A, Krüger R, Riess O
Brain : a journal of neurology 2022 Nov 21;145(11):3968-3984
Brain : a journal of neurology 2022 Nov 21;145(11):3968-3984
The dystonia gene THAP1 controls DNA double-strand break repair choice.
Shinoda K, Zong D, Callen E, Wu W, Dumitrache LC, Belinky F, Chari R, Wong N, Ishikawa M, Stanlie A, Multhaupt-Buell T, Sharma N, Ozelius L, Ehrlich M, McKinnon PJ, Nussenzweig A
Molecular cell 2021 Jun 17;81(12):2611-2624.e10
Molecular cell 2021 Jun 17;81(12):2611-2624.e10
Unraveling Molecular Mechanisms of THAP1 Missense Mutations in DYT6 Dystonia.
Cheng F, Walter M, Wassouf Z, Hentrich T, Casadei N, Schulze-Hentrich J, Barbuti P, Krueger R, Riess O, Grundmann-Hauser K, Ott T
Journal of molecular neuroscience : MN 2020 Jul;70(7):999-1008
Journal of molecular neuroscience : MN 2020 Jul;70(7):999-1008
The DYT6 Dystonia Protein THAP1 Regulates Myelination within the Oligodendrocyte Lineage.
Yellajoshyula D, Liang CC, Pappas SS, Penati S, Yang A, Mecano R, Kumaran R, Jou S, Cookson MR, Dauer WT
Developmental cell 2017 Jul 10;42(1):52-67.e4
Developmental cell 2017 Jul 10;42(1):52-67.e4
Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia.
Meyer E, Carss KJ, Rankin J, Nichols JM, Grozeva D, Joseph AP, Mencacci NE, Papandreou A, Ng J, Barral S, Ngoh A, Ben-Pazi H, Willemsen MA, Arkadir D, Barnicoat A, Bergman H, Bhate S, Boys A, Darin N, Foulds N, Gutowski N, Hills A, Houlden H, Hurst JA, Israel Z, Kaminska M, Limousin P, Lumsden D, McKee S, Misra S, Mohammed SS, Nakou V, Nicolai J, Nilsson M, Pall H, Peall KJ, Peters GB, Prabhakar P, Reuter MS, Rump P, Segel R, Sinnema M, Smith M, Turnpenny P, White SM, Wieczorek D, Wiethoff S, Wilson BT, Winter G, Wragg C, Pope S, Heales SJ, Morrogh D, UK10K Consortium, Deciphering Developmental Disorders Study, NIHR BioResource Rare Diseases Consortium, Pittman A, Carr LJ, Perez-Dueñas B, Lin JP, Reis A, Gahl WA, Toro C, Bhatia KP, Wood NW, Kamsteeg EJ, Chong WK, Gissen P, Topf M, Dale RC, Chubb JR, Raymond FL, Kurian MA
Nature genetics 2017 Feb;49(2):223-237
Nature genetics 2017 Feb;49(2):223-237
Abnormalities of motor function, transcription and cerebellar structure in mouse models of THAP1 dystonia.
Ruiz M, Perez-Garcia G, Ortiz-Virumbrales M, Méneret A, Morant A, Kottwitz J, Fuchs T, Bonet J, Gonzalez-Alegre P, Hof PR, Ozelius LJ, Ehrlich ME
Human molecular genetics 2015 Dec 20;24(25):7159-70
Human molecular genetics 2015 Dec 20;24(25):7159-70
Dystonia type 6 gene product Thap1: identification of a 50 kDa DNA-binding species in neuronal nuclear fractions.
Ortiz-Virumbrales M, Ruiz M, Hone E, Dolios G, Wang R, Morant A, Kottwitz J, Ozelius LJ, Gandy S, Ehrlich ME
Acta neuropathologica communications 2014 Sep 18;2:139
Acta neuropathologica communications 2014 Sep 18;2:139
Stress-induced changes in gene interactions in human cells.
Nayak RR, Bernal WE, Lee JW, Kearns MJ, Cheung VG
Nucleic acids research 2014 Feb;42(3):1757-71
Nucleic acids research 2014 Feb;42(3):1757-71
Neural expression of the transcription factor THAP1 during development in rat.
Zhao Y, Xiao J, Gong S, Clara JA, Ledoux MS
Neuroscience 2013 Feb 12;231:282-95
Neuroscience 2013 Feb 12;231:282-95
The dystonia gene DYT1 is repressed by the transcription factor THAP1 (DYT6).
Kaiser FJ, Osmanoric A, Rakovic A, Erogullari A, Uflacker N, Braunholz D, Lohnau T, Orolicki S, Albrecht M, Gillessen-Kaesbach G, Klein C, Lohmann K
Annals of neurology 2010 Oct;68(4):554-9
Annals of neurology 2010 Oct;68(4):554-9
Direct interaction between causative genes of DYT1 and DYT6 primary dystonia.
Gavarini S, Cayrol C, Fuchs T, Lyons N, Ehrlich ME, Girard JP, Ozelius LJ
Annals of neurology 2010 Oct;68(4):549-53
Annals of neurology 2010 Oct;68(4):549-53
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 12584-1-AP(THAP1 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The THAP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human THAP1. This antibody recognizes human,mouse,rat antigen. The THAP1 antibody has been validated for the following applications: ELISA, IHC, WB analysis.