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- Antibody Data
- Antigen structure
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- Flow cytometry [1]
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- Product number
- 351502 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#351502, RRID:AB_10896430
- Product name
- Purified anti-human Siglec-9
- Antibody type
- Monoclonal
- Antigen
- Recombinant Siglec-9 fused to Fc region of human IgG
- Description
- Siglecs are cell surface receptors belonging to the immunoglobulin superfamily that recognize sugar antigens. The extracellular domain of siglec-9 contains an IgV region, which binds sialic acid, followed by two IgC regions. Siglec 9 and siglec 6-8,10-12 are CD33 (siglec 3) like siglecs, which have two ITIMs in the cytoplasmic tails, suggesting their functional involvement in signal transduction. It is highly expressed on neutrophils and monocytes, and at lower levels on the subpopulations of T and B lymphocytes and NK cells. Siglec-9 plays a role in negative regulation of T cell activation, and it also affects neutrophil apoptosis.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood granulocytes were stained with purified Siglec-9 (clone K8) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram, followed by anti-mouse IgG PE.
- Conjugate
- Unconjugated
