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- Antibody Data
- Antigen structure
- References [23]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 13640-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13640-1-AP, RRID:AB_2063569
- Product name
- BCAT1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BCAT1 antibody (Cat. #13640-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references MiR-320a Acts as a Tumor Suppressor in Somatotroph Pituitary Neuroendocrine Tumors by Targeting BCAT1.
Branched-Chain Amino Acid Accumulation Fuels the Senescence-Associated Secretory Phenotype.
Potential 'anti-cancer' effects of esketamine on proliferation, apoptosis, migration and invasion in esophageal squamous carcinoma cells.
Suppressing Mesenchymal Stromal Cell Ferroptosis Via Targeting a Metabolism-Epigenetics Axis Corrects their Poor Retention and Insufficient Healing Benefits in the Injured Liver Milieu.
Enhanced BCAT1 activity and BCAA metabolism promotes RhoC activity in cancer progression.
Branched-chain aminotransferase 1 promotes Schwann cell migration and proliferation to accelerate facial nerve regeneration through the Twist/FoxC1 and Sox2 pathways.
Downregulation of extramitochondrial BCKDH and its uncoupling from AMP deaminase in type 2 diabetic OLETF rat hearts.
Differential expression pattern, bioinformatics analysis, and validation of circRNA and mRNA in patients with arteriosclerosis.
The proatherosclerotic function of BCAT1 in atherosclerosis development of aged-apolipoprotein E-deficient mice.
Impaired expression of BCAT1 relates to muscle atrophy of mouse model of sarcopenia.
Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2.
Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma.
Comprehensive single-cell transcriptional profiling defines shared and unique epithelial injury responses during kidney fibrosis.
BCAT1 Activates PI3K/AKT/mTOR Pathway and Contributes to the Angiogenesis and Tumorigenicity of Gastric Cancer.
Branched-chain amino acids govern the high learning ability phenotype in Tokai high avoider (THA) rats.
BCAT1 overexpression regulates proliferation and c‑Myc/GLUT1 signaling in head and neck squamous cell carcinoma.
RNA-binding motif protein RBM47 promotes tumorigenesis in nasopharyngeal carcinoma through multiple pathways.
miR-98-5p inhibits gastric cancer cell stemness and chemoresistance by targeting branched-chain aminotransferases 1.
Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma.
Oxoeicosanoid receptor inhibition alleviates acute myocardial infarction through activation of BCAT1.
BCAT1 Overexpression Promotes Proliferation, Invasion, and Wnt Signaling in Non-Small Cell Lung Cancers.
BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma.
BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism.
Zhao S, Li B, Gao H, Zhang Y
Neuroendocrinology 2024;114(1):14-24
Neuroendocrinology 2024;114(1):14-24
Branched-Chain Amino Acid Accumulation Fuels the Senescence-Associated Secretory Phenotype.
Liang Y, Pan C, Yin T, Wang L, Gao X, Wang E, Quang H, Huang D, Tan L, Xiang K, Wang Y, Alexander PB, Li QJ, Yao TP, Zhang Z, Wang XF
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(2):e2303489
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(2):e2303489
Potential 'anti-cancer' effects of esketamine on proliferation, apoptosis, migration and invasion in esophageal squamous carcinoma cells.
Li C, Shi J, Wei S, Jia H
European journal of medical research 2023 Nov 15;28(1):517
European journal of medical research 2023 Nov 15;28(1):517
Suppressing Mesenchymal Stromal Cell Ferroptosis Via Targeting a Metabolism-Epigenetics Axis Corrects their Poor Retention and Insufficient Healing Benefits in the Injured Liver Milieu.
Hu G, Cui Z, Chen X, Sun F, Li T, Li C, Zhang L, Guo X, Zhao H, Xia Y, Yan W, Yi W, Fan M, Yang R, Wang S, Tao L, Zhang F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(13):e2206439
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(13):e2206439
Enhanced BCAT1 activity and BCAA metabolism promotes RhoC activity in cancer progression.
Qian L, Li N, Lu XC, Xu M, Liu Y, Li K, Zhang Y, Hu K, Qi YT, Yao J, Wu YL, Wen W, Huang S, Chen ZJ, Yin M, Lei QY
Nature metabolism 2023 Jul;5(7):1159-1173
Nature metabolism 2023 Jul;5(7):1159-1173
Branched-chain aminotransferase 1 promotes Schwann cell migration and proliferation to accelerate facial nerve regeneration through the Twist/FoxC1 and Sox2 pathways.
Chen Z, Tang Y, Zhu W, Wang H, Cai X, Shen Y, Wang B, Zhao H, Zhu J, Li S
International journal of biological macromolecules 2023 Jul 1;242(Pt 2):124870
International journal of biological macromolecules 2023 Jul 1;242(Pt 2):124870
Downregulation of extramitochondrial BCKDH and its uncoupling from AMP deaminase in type 2 diabetic OLETF rat hearts.
Ogawa T, Kouzu H, Osanami A, Tatekoshi Y, Sato T, Kuno A, Fujita Y, Ino S, Shimizu M, Toda Y, Ohwada W, Yano T, Tanno M, Miki T, Miura T
Physiological reports 2023 Feb;11(4):e15608
Physiological reports 2023 Feb;11(4):e15608
Differential expression pattern, bioinformatics analysis, and validation of circRNA and mRNA in patients with arteriosclerosis.
Liu Y, Wang K, Li G, Chen Z
Frontiers in cardiovascular medicine 2022;9:942797
Frontiers in cardiovascular medicine 2022;9:942797
The proatherosclerotic function of BCAT1 in atherosclerosis development of aged-apolipoprotein E-deficient mice.
Tan L, Lu J, Zhang C, Meng L, Zhu Q
Biochemical and biophysical research communications 2022 Nov 26;631:93-101
Biochemical and biophysical research communications 2022 Nov 26;631:93-101
Impaired expression of BCAT1 relates to muscle atrophy of mouse model of sarcopenia.
Ouyang H, Gao X, Zhang J
BMC musculoskeletal disorders 2022 May 13;23(1):450
BMC musculoskeletal disorders 2022 May 13;23(1):450
Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2.
Fu F, Lai Q, Hu J, Zhang L, Zhu X, Kou J, Yu B, Li F
Antioxidants (Basel, Switzerland) 2022 Mar 18;11(3)
Antioxidants (Basel, Switzerland) 2022 Mar 18;11(3)
Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma.
Zhang B, Peng H, Zhou M, Bao L, Wang C, Cai F, Zhang H, Wang JE, Niu Y, Chen Y, Wang Y, Hatanpaa KJ, Copland JA, DeBerardinis RJ, Wang Y, Luo W
Cancer research 2022 Jul 5;82(13):2388-2402
Cancer research 2022 Jul 5;82(13):2388-2402
Comprehensive single-cell transcriptional profiling defines shared and unique epithelial injury responses during kidney fibrosis.
Li H, Dixon EE, Wu H, Humphreys BD
Cell metabolism 2022 Dec 6;34(12):1977-1998.e9
Cell metabolism 2022 Dec 6;34(12):1977-1998.e9
BCAT1 Activates PI3K/AKT/mTOR Pathway and Contributes to the Angiogenesis and Tumorigenicity of Gastric Cancer.
Shu X, Zhan PP, Sun LX, Yu L, Liu J, Sun LC, Yang ZH, Ran YL, Sun YM
Frontiers in cell and developmental biology 2021;9:659260
Frontiers in cell and developmental biology 2021;9:659260
Branched-chain amino acids govern the high learning ability phenotype in Tokai high avoider (THA) rats.
Shida Y, Endo H, Owada S, Inagaki Y, Sumiyoshi H, Kamiya A, Eto T, Tatemichi M
Scientific reports 2021 Nov 29;11(1):23104
Scientific reports 2021 Nov 29;11(1):23104
BCAT1 overexpression regulates proliferation and c‑Myc/GLUT1 signaling in head and neck squamous cell carcinoma.
Wang H, Wang F, Ouyang W, Jiang X, Wang Y
Oncology reports 2021 May;45(5)
Oncology reports 2021 May;45(5)
RNA-binding motif protein RBM47 promotes tumorigenesis in nasopharyngeal carcinoma through multiple pathways.
Xu XC, He S, Zhou YQ, Liu CJ, Liu SQ, Peng W, Liu YX, Wei PP, Bei JX, Luo CL
Journal of genetics and genomics = Yi chuan xue bao 2021 Jul 20;48(7):595-605
Journal of genetics and genomics = Yi chuan xue bao 2021 Jul 20;48(7):595-605
miR-98-5p inhibits gastric cancer cell stemness and chemoresistance by targeting branched-chain aminotransferases 1.
Zhan P, Shu X, Chen M, Sun L, Yu L, Liu J, Sun L, Yang Z, Ran Y
Life sciences 2021 Jul 1;276:119405
Life sciences 2021 Jul 1;276:119405
Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma.
Zhang B, Chen Y, Shi X, Zhou M, Bao L, Hatanpaa KJ, Patel T, DeBerardinis RJ, Wang Y, Luo W
Cellular and molecular life sciences : CMLS 2021 Jan;78(1):195-206
Cellular and molecular life sciences : CMLS 2021 Jan;78(1):195-206
Oxoeicosanoid receptor inhibition alleviates acute myocardial infarction through activation of BCAT1.
Lai Q, Yuan G, Shen L, Zhang L, Fu F, Liu Z, Zhang Y, Kou J, Liu S, Yu B, Li F
Basic research in cardiology 2021 Jan 23;116(1):3
Basic research in cardiology 2021 Jan 23;116(1):3
BCAT1 Overexpression Promotes Proliferation, Invasion, and Wnt Signaling in Non-Small Cell Lung Cancers.
Lin X, Tan S, Fu L, Dong Q
OncoTargets and therapy 2020;13:3583-3594
OncoTargets and therapy 2020;13:3583-3594
BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma.
Li JT, Yin M, Wang D, Wang J, Lei MZ, Zhang Y, Liu Y, Zhang L, Zou SW, Hu LP, Zhang ZG, Wang YP, Wen WY, Lu HJ, Chen ZJ, Su D, Lei QY
Nature cell biology 2020 Feb;22(2):167-174
Nature cell biology 2020 Feb;22(2):167-174
BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism.
Wang ZQ, Faddaoui A, Bachvarova M, Plante M, Gregoire J, Renaud MC, Sebastianelli A, Guillemette C, Gobeil S, Macdonald E, Vanderhyden B, Bachvarov D
Oncotarget 2015 Oct 13;6(31):31522-43
Oncotarget 2015 Oct 13;6(31):31522-43
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human kidney tissue were subjected to SDS PAGE followed by western blot with 13640-1-AP(BCAT1 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BCAT1/ECA39 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BCAT1/ECA39. This antibody recognizes human,mouse,rat antigen. The BCAT1/ECA39 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
