BS9259

antibody from Bioworld Technology, Inc

Targeting: CD70 CD27L, CD27LG, TNFSF7

Western blot (Data presented on provider website)

Antibody Data

Product number

BS9259

Provider

Bioworld Technology, Inc

Product name

CD70 (D101) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide, corresponding to amino acids 80-130 of Human CD70.

Description

The tumor necrosis factor (TNF) receptor family is composed of several type I integral membrane glycoproteins that exhibit homology in their cystine-rich extracellular domains. Members of this family include FAS, OX40, CD27 and CD30. Ligands for these receptors are often type II transmembrane glycoproteins, as is the case for CD27 and CD30. CD27 is a homodimeric lymphocyte-specific surface antigen present on T and B lymphocytes. Activation of the CD3 complex via the T cell receptor for antigen leads to an increase in CD27 expression. Together, CD27 and its ligand, CD70, generate co-stimulatory signals required for complete T cell activation. CD30 is a surface marker for neoplastic cells of the Hodgkin£ªs lymphoma and related hematologic malignancies. CD30L has been shown to enhance the proliferation of the Hodgkin£ªs cell line HDLM-2, but exerts antiproliferative effects on large cell anaplastic lymphoma cell lines.

Reactivity

Human

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.