V3033

antibody from NSJ Bioreagents

Targeting: CD70 CD27L, CD27LG, TNFSF7

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Blocking/Neutralizing (Recommended by provider)

Antibody Data

Product number

V3033

Provider

NSJ Bioreagents

Product name

CD70 Antibody

Antibody type

Monoclonal

Antigen

The human WM-1 (Waldenstrom s macroglobulinemia) cell line was used as the immunogen for the CD70 antibody.

Description

Protein G purified antibody

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antibody clone number

BU69

Vial size

20 µg, 100 µg (with sodium azide), 100 µg (without sodium azide), 7 ml (prediluted for IHC use, if applicable)

Storage

Store the CD70 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

References

Submitted references

Clinical significance of CD70 expression on T cells in human T-lymphotropic virus type-1 carriers and adult T cell leukemia/ lymphoma patients.

Masamoto I, Yoshimitsu M, Kuroki A, Horai S, Ezinne CC, Kozako T, Hachiman M, Kamada Y, Baba M, Arima N
Leukemia & lymphoma 2016 Mar;57(3):685-91

---

Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab.

Ramakrishna V, Sundarapandiyan K, Zhao B, Bylesjo M, Marsh HC, Keler T
Journal for immunotherapy of cancer 2015;3:37

---

High functional CD70 expression on α-type 1-polarized dendritic cells from patients with chronic lymphocytic leukaemia.

Junevik K, Werlenius O, Fogelstrand L, Karlsson-Parra A, Andersson PO
Scandinavian journal of immunology 2014 Jun;79(6):415-22

---

CD27(+)CD56Bright natural killer cells may be involved in spontaneous clearance of acute hepatitis C in HIV-positive patients.

Eisenhardt M, Glässner A, Wolter F, Krämer B, Kokordelis P, Nischalke HD, Boesecke C, Rockstroh JK, Spengler U, Nattermann J
AIDS (London, England) 2014 Aug 24;28(13):1879-84

---

CD70-CD27 ligation between neural stem cells and CD4+ T cells induces Fas-FasL-mediated T-cell death.

Lee EM, Hurh S, Cho B, Oh KH, Kim SU, Surh CD, Sprent J, Yang J, Kim JY, Ahn C
Stem cell research & therapy 2013 May 21;4(3):56

---

Soluble CD27 induces IgG production through activation of antigen-primed B cells.

Dang LV, Nilsson A, Ingelman-Sundberg H, Cagigi A, Gelinck LB, Titanji K, De Milito A, Grutzmeier S, Hedlund J, Kroon FP, Chiodi F
Journal of internal medicine 2012 Mar;271(3):282-93

---

Irradiation enhances human T-cell function by upregulating CD70 expression on antigen-presenting cells in vitro.

Huang J, Wang QJ, Yang S, Li YF, El-Gamil M, Rosenberg SA, Robbins PF
Journal of immunotherapy (Hagerstown, Md. : 1997) 2011 May;34(4):327-35

---

Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4(+) T-cell differentiation.

Arimoto-Miyamoto K, Kadowaki N, Kitawaki T, Iwata S, Morimoto C, Uchiyama T
Immunology 2010 May;130(1):137-49

---

Homotypic T-cell/T-cell interaction induces T-cell activation, proliferation, and differentiation.

Ramming A, Thümmler K, Schulze-Koops H, Skapenko A
Human immunology 2009 Nov;70(11):873-81

---

Helper B cells promote cytotoxic T cell survival and proliferation independently of antigen presentation through CD27/CD70 interactions.

Deola S, Panelli MC, Maric D, Selleri S, Dmitrieva NI, Voss CY, Klein H, Stroncek D, Wang E, Marincola FM
Journal of immunology (Baltimore, Md. : 1950) 2008 Feb 1;180(3):1362-72