18068-1-AP

antibody from Proteintech Group

Targeting: PDHA1 PDHA

Provider product page for 18068-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [104]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 18068-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#18068-1-AP, RRID:AB_2162931
Product name: PDH E1 Alpha antibody
Antibody type: Polyclonal
Description: KD/KO validated PDH E1 Alpha antibody (Cat. #18068-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PDHA1 protein structure - 18068-1-AP shown in red.

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Shaoyao Gancao Decoction alleviates ulcerative colitis-associated secondary liver injury by inhibiting the phosphorylation of pyruvate dehydrogenase in macrophages.

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PDHA1-acetylation signaling suppresses cuproptosis to attenuate anti-androgen effect in prostate cancer.

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M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy.

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International journal of biological sciences 2023;19(5):1543-1563

ITGB1-mediated molecular landscape and cuproptosis phenotype induced the worse prognosis in diffuse gastric cancer.

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Frontiers in oncology 2023;13:1115510

Extracellular ATP-induced calcium oscillations regulating the differentiation of osteoblasts through aerobic oxidation metabolism pathways.

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Artificial intelligence reveals dysregulation of osteosarcoma and cuproptosis-related biomarkers, PDHA1, CDKN2A and neutrophils.

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Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment.

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PloS one 2022;17(4):e0266601

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Pharmacological research 2022 Nov;185:106490

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Nature communications 2022 Nov 28;13(1):7338

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Legionella pneumophila temporally regulates the activity of ADP/ATP translocases by reversible ADP-ribosylation.

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mLife 2022 Mar;1(1):51-65

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Acta pharmacologica Sinica 2022 Jun;43(6):1581-1593

Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited.

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Nature metabolism 2022 Jun;4(6):711-723

Beneficial effects of aloperine on inflammation and oxidative stress by suppressing necroptosis in lipopolysaccharide-induced acute lung injury mouse model.

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Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154074

A novel regulatory mechanism of geniposide for improving glucose homeostasis mediated by circulating RBP4.

Liu J, Song C, Nie C, Sun Y, Wang Y, Xue L, Fan M, Qian H, Wang L, Li Y
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Legionella pneumophila modulates host energy metabolism by ADP-ribosylation of ADP/ATP translocases.

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eLife 2022 Jan 27;11

Myricetin Restores Aβ-Induced Mitochondrial Impairments in N2a-SW Cells.

Yao X, Zhang J, Lu Y, Deng Y, Zhao R, Xiao S
ACS chemical neuroscience 2022 Feb 16;13(4):454-463

Myoglobin-mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans.

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Clinical and translational medicine 2022 Dec;12(12):e1108

A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration.

Du J, Zheng L, Gao P, Yang H, Yang WJ, Guo F, Liang R, Feng M, Wang Z, Zhang Z, Bai L, Bu Y, Xing S, Zheng W, Wang X, Quan L, Hu X, Wu H, Chen Z, Chen L, Wei K, Zhang Z, Zhu X, Zhang X, Tu Q, Zhao SM, Lei X, Xiong JW
Cell stem cell 2022 Apr 7;29(4):545-558.e13

Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation.

Lin HC, Chen YJ, Wei YH, Lin HA, Chen CC, Liu TF, Hsieh YL, Huang KY, Lin KH, Wang HH, Chen LC
Frontiers in immunology 2021;12:630380

Growth hormone receptor disrupts glucose homeostasis via promoting and stabilizing retinol binding protein 4.

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Theranostics 2021;11(17):8283-8300

miR-183 and miR-96 orchestrate both glucose and fat utilization in skeletal muscle.

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EMBO reports 2021 Sep 6;22(9):e52247

HIF-1 regulates energy metabolism of the Tibetan chicken brain during embryo development under hypoxia.

Tang Q, Xu Q, Ding C, Zhang H, Ling Y, Wu C, Fang M
American journal of physiology. Regulatory, integrative and comparative physiology 2021 May 1;320(5):R704-R713

Localization of myoglobin in mitochondria: implication in regulation of mitochondrial respiration in rat skeletal muscle.

Koma R, Shibaguchi T, Pérez López C, Oka T, Jue T, Takakura H, Masuda K
Physiological reports 2021 Mar;9(5):e14769

Resveratrol Is a Natural Inhibitor of Human Intestinal Mast Cell Activation and Phosphorylation of Mitochondrial ERK1/2 and STAT3.

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International journal of molecular sciences 2021 Jul 16;22(14)

Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice.

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Journal of diabetes research 2020;2020:2817972

Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.

Chen L, Peng J, Wang Y, Jiang H, Wang W, Dai J, Tang M, Wei Y, Kuang H, Xu G, Xu H, Zhou F
American journal of translational research 2020;12(2):428-446

A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer.

Kodama M, Oshikawa K, Shimizu H, Yoshioka S, Takahashi M, Izumi Y, Bamba T, Tateishi C, Tomonaga T, Matsumoto M, Nakayama KI
Nature communications 2020 Mar 17;11(1):1320

Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction.

Liu Y, Sun L, Zheng L, Su M, Liu H, Wei Y, Li D, Wang Y, Dai C, Gong Y, Zhao C, Li Y
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jan;393(1):25-33

Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function.

Kľučková K, Thakker A, Vettore L, Escribano-Gonzalez C, Hindshaw RL, Tearle JLE, Goncalves J, Kaul B, Lavery GG, Favier J, Tennant DA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):303-315

The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer.

Zhuang Y, Ly RC, Frazier CV, Yu J, Qin S, Fan XY, Goetz MP, Boughey JC, Weinshilboum R, Wang L
Cancer & metabolism 2019;7:1

ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer.

Zhao H, Wu S, Li H, Duan Q, Zhang Z, Shen Q, Wang C, Yin T
Molecular therapy oncolytics 2019 Sep 27;14:299-312

Low-dose PCB126 compromises circadian rhythms associated with disordered glucose and lipid metabolism in mice.

Shen X, Chen Y, Zhang J, Yan X, Liu W, Guo Y, Shan Q, Liu S
Environment international 2019 Jul;128:146-157

Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer.

Ma W, Zhao X, Wang K, Liu J, Huang G
Cancer biology & therapy 2018;19(9):835-846

Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins.

Horita H, Law A, Middleton K
Proteomes 2018 May 22;6(2)

(Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and Hepatosteatosis.

Ren L, Sun Y, Lu H, Ye D, Han L, Wang N, Daugherty A, Li F, Wang M, Su F, Tao W, Sun J, Zelcer N, Mullick AE, Danser AHJ, Jiang Y, He Y, Ruan X, Lu X
Circulation research 2018 Mar 2;122(5):730-741

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis.

Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J
Nature cell biology 2018 Feb;20(2):186-197

Exogenous H(2)S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice.

Sun Y, Tian Z, Liu N, Zhang L, Gao Z, Sun X, Yu M, Wu J, Yang F, Zhao Y, Ren H, Chen H, Zhao D, Wang Y, Dong S, Xu C, Lu F, Zhang W
Journal of molecular medicine (Berlin, Germany) 2018 Apr;96(3-4):281-299

The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis.

Li G, Li M, Hu J, Lei R, Xiong H, Ji H, Yin H, Wei Q, Hu G
Oncogene 2017 Feb 16;36(7):989-998

Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.

Li P, Zhang D, Shen L, Dong K, Wu M, Ou Z, Shi D
Scientific reports 2016 Mar 9;6:22831

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer.

Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, O'Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L, Chin CR, Stephanopolous G, Mott BT, Jacks T, Clish CB, Vander Heiden MG
Cell metabolism 2016 Mar 8;23(3):517-28

ROS-mediated glucose metabolic reprogram induces insulin resistance in type 2 diabetes.

Dong K, Ni H, Wu M, Tang Z, Halim M, Shi D
Biochemical and biophysical research communications 2016 Aug 5;476(4):204-211

The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.

Liu F, Zhang W, You X, Liu Y, Li Y, Wang Z, Wang Y, Zhang X, Ye L
Oncotarget 2015 Sep 29;6(29):27199-213

Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.

Zhang J, Fan J, Venneti S, Cross JR, Takagi T, Bhinder B, Djaballah H, Kanai M, Cheng EH, Judkins AR, Pawel B, Baggs J, Cherry S, Rabinowitz JD, Thompson CB
Molecular cell 2014 Oct 23;56(2):205-218

Mitochondrial bioenergetic deficits in the hippocampi of rats with chronic ischemia-induced vascular dementia.

Du J, Ma M, Zhao Q, Fang L, Chang J, Wang Y, Fei R, Song X
Neuroscience 2013 Feb 12;231:345-52

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse brain tissue were subjected to SDS PAGE followed by western blot with 18068-1-AP(PDHA1 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using PDHA1 antibody 18068-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human heart using 18068-1-AP(PDHA1 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human heart using 18068-1-AP(PDHA1 antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue