Antibody data
- Antibody Data
- Antigen structure
- References [62]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
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- Product number
- 18068-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18068-1-AP, RRID:AB_2162931
- Product name
- PDH E1 Alpha antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PDH E1 Alpha antibody (Cat. #18068-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine.
Targeting the PDK/PDH axis to reverse metabolic abnormalities by structure-based virtual screening with in vitro and in vivo experiments.
Phosphorylation of pyruvate dehydrogenase inversely associates with neuronal activity.
Testosterone regulates thymic remodeling by altering metabolic reprogramming in male rats.
Clinical features and molecular landscape of cuproptosis signature-related molecular subtype in gastric cancer.
Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation.
Lactate accumulation induced by Akt2-PDK1 signaling promotes pulmonary fibrosis.
Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat.
M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy.
ITGB1-mediated molecular landscape and cuproptosis phenotype induced the worse prognosis in diffuse gastric cancer.
Extracellular ATP-induced calcium oscillations regulating the differentiation of osteoblasts through aerobic oxidation metabolism pathways.
Metabolic modulation of mitochondrial mass during CD4(+) T cell activation.
PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF-1α protein stability and gene expression.
Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes.
PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway.
Extracellular Calcium-Induced Calcium Transient Regulating the Proliferation of Osteoblasts through Glycolysis Metabolism Pathways.
Artificial intelligence reveals dysregulation of osteosarcoma and cuproptosis-related biomarkers, PDHA1, CDKN2A and neutrophils.
Phosphorylation of pyruvate dehydrogenase marks the inhibition of in vivo neuronal activity.
Pyruvate metabolism controls chromatin remodeling during CD4(+) T cell activation.
AMPK regulates homeostasis of invasion and viability in trophoblasts by redirecting glucose metabolism: Implications for pre-eclampsia.
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment.
Formononetin attenuates high glucose-induced neurotoxicity by negatively regulating oxidative stress and mitochondrial dysfunction in Schwann cells via activation of SIRT3.
Huangqi-Danshen decoction reshapes renal glucose metabolism profiles that delays chronic kidney disease progression.
MCC950, a Selective NLRP3 Inhibitor, Attenuates Adverse Cardiac Remodeling Following Heart Failure Through Improving the Cardiometabolic Dysfunction in Obese Mice.
Targeting pancreatic cancer with combinatorial treatment of CPI-613 and inhibitors of lactate metabolism.
Changes in the Expression of MIF and Other Key Enzymes of Energy Metabolism in the Myocardia of Broiler Chickens with Ascites Syndrome.
Therapeutic targeting of glutamate dehydrogenase 1 that links metabolic reprogramming and Snail-mediated epithelial-mesenchymal transition in drug-resistant lung cancer.
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism.
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming.
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited.
Beneficial effects of aloperine on inflammation and oxidative stress by suppressing necroptosis in lipopolysaccharide-induced acute lung injury mouse model.
A novel regulatory mechanism of geniposide for improving glucose homeostasis mediated by circulating RBP4.
Legionella pneumophila modulates host energy metabolism by ADP-ribosylation of ADP/ATP translocases.
Myricetin Restores Aβ-Induced Mitochondrial Impairments in N2a-SW Cells.
Myoglobin-mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans.
A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration.
Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation.
Growth hormone receptor disrupts glucose homeostasis via promoting and stabilizing retinol binding protein 4.
HIF-1 regulates energy metabolism of the Tibetan chicken brain during embryo development under hypoxia.
Localization of myoglobin in mitochondria: implication in regulation of mitochondrial respiration in rat skeletal muscle.
Resveratrol Is a Natural Inhibitor of Human Intestinal Mast Cell Activation and Phosphorylation of Mitochondrial ERK1/2 and STAT3.
Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice.
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer.
Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction.
Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function.
The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer.
ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer.
Low-dose PCB126 compromises circadian rhythms associated with disordered glucose and lipid metabolism in mice.
Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer.
Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins.
(Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and Hepatosteatosis.
RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis.
Exogenous H(2)S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice.
The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis.
Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.
Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer.
ROS-mediated glucose metabolic reprogram induces insulin resistance in type 2 diabetes.
The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.
Mitochondrial bioenergetic deficits in the hippocampi of rats with chronic ischemia-induced vascular dementia.
Li M, Wang Y, Wei X, Cai WF, Wu J, Zhu M, Wang Y, Liu YH, Xiong J, Qu Q, Chen Y, Tian X, Yao L, Xie R, Li X, Chen S, Huang X, Zhang C, Xie C, Wu Y, Xu Z, Zhang B, Jiang B, Wang ZC, Li Q, Li G, Lin SY, Yu L, Piao HL, Deng X, Han J, Zhang CS, Lin SC
Cell research 2024 Oct;34(10):683-706
Cell research 2024 Oct;34(10):683-706
Targeting the PDK/PDH axis to reverse metabolic abnormalities by structure-based virtual screening with in vitro and in vivo experiments.
Yue J, Xu J, Yin Y, Shu Y, Li Y, Li T, Zou Z, Wang Z, Li F, Zhang M, Liang S, He X, Liu Z, Wang Y
International journal of biological macromolecules 2024 Mar;262(Pt 1):129970
International journal of biological macromolecules 2024 Mar;262(Pt 1):129970
Phosphorylation of pyruvate dehydrogenase inversely associates with neuronal activity.
Yang D, Wang Y, Qi T, Zhang X, Shen L, Ma J, Pang Z, Lal NK, McClatchy DB, Seradj SH, Leung VH, Wang K, Xie Y, Polli FS, Maximov A, Gonzalez OC, de Lecea L, Cline HT, Augustine V, Yates JR 3rd, Ye L
Neuron 2024 Mar 20;112(6):959-971.e8
Neuron 2024 Mar 20;112(6):959-971.e8
Testosterone regulates thymic remodeling by altering metabolic reprogramming in male rats.
Li D, Yao H, Ren Y, Shang J, Han X, Cao X, Song T, Zeng X
General and comparative endocrinology 2024 Mar 1;348:114448
General and comparative endocrinology 2024 Mar 1;348:114448
Clinical features and molecular landscape of cuproptosis signature-related molecular subtype in gastric cancer.
Chong W, Ren H, Chen H, Xu K, Zhu X, Liu Y, Sang Y, Li H, Liu J, Ye C, Shang L, Jing C, Li L
iMeta 2024 Jun;3(3):e190
iMeta 2024 Jun;3(3):e190
Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation.
Mao Y, Zhang J, Zhou Q, He X, Zheng Z, Wei Y, Zhou K, Lin Y, Yu H, Zhang H, Zhou Y, Lin P, Wu B, Yuan Y, Zhao J, Xu W, Zhao S
Cell research 2024 Jan;34(1):13-30
Cell research 2024 Jan;34(1):13-30
Lactate accumulation induced by Akt2-PDK1 signaling promotes pulmonary fibrosis.
Sun Z, Ji Z, He W, Duan R, Qu J, Yu G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23426
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23426
Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat.
Li L, Niemann B, Knapp F, Werner S, Mühlfeld C, Schneider JP, Jurida LM, Molenda N, Schmitz ML, Yin X, Mayr M, Schulz R, Kracht M, Rohrbach S
Basic research in cardiology 2024 Aug;119(4):587-611
Basic research in cardiology 2024 Aug;119(4):587-611
M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy.
Zhong C, Long Z, Yang T, Wang S, Zhong W, Hu F, Teoh JY, Lu J, Mao X
International journal of biological sciences 2023;19(5):1543-1563
International journal of biological sciences 2023;19(5):1543-1563
ITGB1-mediated molecular landscape and cuproptosis phenotype induced the worse prognosis in diffuse gastric cancer.
Zhu X, Chen H, Li H, Ren H, Ye C, Xu K, Liu J, Du F, Zhang Z, Liu Y, Xie X, Wang M, Ma T, Chong W, Shang L, Li L
Frontiers in oncology 2023;13:1115510
Frontiers in oncology 2023;13:1115510
Extracellular ATP-induced calcium oscillations regulating the differentiation of osteoblasts through aerobic oxidation metabolism pathways.
Gao X, Di X, Li J, Kang Y, Xie W, Sun L, Zhang J
Journal of bone and mineral metabolism 2023 Sep;41(5):606-620
Journal of bone and mineral metabolism 2023 Sep;41(5):606-620
Metabolic modulation of mitochondrial mass during CD4(+) T cell activation.
Kurmi K, Liang D, van de Ven R, Georgiev P, Gassaway BM, Han S, Notarangelo G, Harris IS, Yao CH, Park JS, Hu SH, Peng J, Drijvers JM, Boswell S, Sokolov A, Dougan SK, Sorger PK, Gygi SP, Sharpe AH, Haigis MC
Cell chemical biology 2023 Sep 21;30(9):1064-1075.e8
Cell chemical biology 2023 Sep 21;30(9):1064-1075.e8
PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF-1α protein stability and gene expression.
Ma Z, Mo R, Yang P, Ding Y, Zhang H, Dong Z, Chen Y, Tan Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23215
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23215
Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes.
Yao Y, Shi J, Zhang C, Gao W, Huang N, Liu Y, Yan W, Han Y, Zhou W, Kong L
Cell death & disease 2023 Nov 7;14(11):722
Cell death & disease 2023 Nov 7;14(11):722
PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway.
Ma Z, Ding Y, Ding X, Mou H, Mo R, Tan Q
Cell death discovery 2023 Nov 25;9(1):424
Cell death discovery 2023 Nov 25;9(1):424
Extracellular Calcium-Induced Calcium Transient Regulating the Proliferation of Osteoblasts through Glycolysis Metabolism Pathways.
Gao X, Di X, Li J, Kang Y, Xie W, Sun L, Zhang J
International journal of molecular sciences 2023 Mar 5;24(5)
International journal of molecular sciences 2023 Mar 5;24(5)
Artificial intelligence reveals dysregulation of osteosarcoma and cuproptosis-related biomarkers, PDHA1, CDKN2A and neutrophils.
Jiang J, Zhan X, Wei J, Fan Q, Li H, Li H, Li S, Zhao Y, Yin G, Tang L, Wu Y, Lan M, Qin Y, Guo Q, Xu W, Lu L, Yang Y, Zhang Y, Qu H
Scientific reports 2023 Mar 26;13(1):4927
Scientific reports 2023 Mar 26;13(1):4927
Phosphorylation of pyruvate dehydrogenase marks the inhibition of in vivo neuronal activity.
Yang D, Wang Y, Qi T, Zhang X, Shen L, Ma J, Pang Z, Lal NK, McClatchy DB, Wang K, Xie Y, Polli F, Maximov A, Augustine V, Cline HT, Yates JR, Ye L
bioRxiv : the preprint server for biology 2023 Mar 14;
bioRxiv : the preprint server for biology 2023 Mar 14;
Pyruvate metabolism controls chromatin remodeling during CD4(+) T cell activation.
Mocholi E, Russo L, Gopal K, Ramstead AG, Hochrein SM, Vos HR, Geeven G, Adegoke AO, Hoekstra A, van Es RM, Pittol JR, Vastert S, Rutter J, Radstake T, van Loosdregt J, Berkers C, Mokry M, Anderson CC, O'Connell RM, Vaeth M, Ussher J, Burgering BMT, Coffer PJ
Cell reports 2023 Jun 27;42(6):112583
Cell reports 2023 Jun 27;42(6):112583
AMPK regulates homeostasis of invasion and viability in trophoblasts by redirecting glucose metabolism: Implications for pre-eclampsia.
Xu P, Zheng Y, Liao J, Hu M, Yang Y, Zhang B, Kilby MD, Fu H, Liu Y, Zhang F, Xiong L, Liu X, Jin H, Wu Y, Huang J, Han T, Wen L, Gao R, Fu Y, Fan X, Qi H, Baker PN, Tong C
Cell proliferation 2023 Feb;56(2):e13358
Cell proliferation 2023 Feb;56(2):e13358
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment.
Giafaglione JM, Crowell PD, Delcourt AML, Hashimoto T, Ha SM, Atmakuri A, Nunley NM, Dang RMA, Tian M, Diaz JA, Tika E, Payne MC, Burkhart DL, Li D, Navone NM, Corey E, Nelson PS, Lin NYC, Blanpain C, Ellis L, Boutros PC, Goldstein AS
Nature cell biology 2023 Dec;25(12):1821-1832
Nature cell biology 2023 Dec;25(12):1821-1832
Formononetin attenuates high glucose-induced neurotoxicity by negatively regulating oxidative stress and mitochondrial dysfunction in Schwann cells via activation of SIRT3.
Jiang W, Hu T, Ye C, Hu M, Yu Q, Sun L, Liang J, Chen Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114156
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114156
Huangqi-Danshen decoction reshapes renal glucose metabolism profiles that delays chronic kidney disease progression.
Huang X, Gao L, Deng R, Peng Y, Wu S, Lu J, Liu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114989
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114989
MCC950, a Selective NLRP3 Inhibitor, Attenuates Adverse Cardiac Remodeling Following Heart Failure Through Improving the Cardiometabolic Dysfunction in Obese Mice.
Wang M, Zhao M, Yu J, Xu Y, Zhang J, Liu J, Zheng Z, Ye J, Wang Z, Ye D, Feng Y, Xu S, Pan W, Wei C, Wan J
Frontiers in cardiovascular medicine 2022;9:727474
Frontiers in cardiovascular medicine 2022;9:727474
Targeting pancreatic cancer with combinatorial treatment of CPI-613 and inhibitors of lactate metabolism.
Kumstel S, Schreiber T, Goldstein L, Stenzel J, Lindner T, Joksch M, Zhang X, Wendt EHU, Schönrogge M, Krause B, Vollmar B, Zechner D
PloS one 2022;17(4):e0266601
PloS one 2022;17(4):e0266601
Changes in the Expression of MIF and Other Key Enzymes of Energy Metabolism in the Myocardia of Broiler Chickens with Ascites Syndrome.
Li L, Jia Q, Chen L, Wang W
Animals : an open access journal from MDPI 2022 Sep 20;12(19)
Animals : an open access journal from MDPI 2022 Sep 20;12(19)
Therapeutic targeting of glutamate dehydrogenase 1 that links metabolic reprogramming and Snail-mediated epithelial-mesenchymal transition in drug-resistant lung cancer.
Wang Q, Wu M, Li H, Rao X, Ao L, Wang H, Yao L, Wang X, Hong X, Wang J, Aa J, Sun M, Wang G, Liu J, Zhou F
Pharmacological research 2022 Nov;185:106490
Pharmacological research 2022 Nov;185:106490
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism.
Bussi C, Heunis T, Pellegrino E, Bernard EM, Bah N, Dos Santos MS, Santucci P, Aylan B, Rodgers A, Fearns A, Mitschke J, Moore C, MacRae JI, Greco M, Reinheckel T, Trost M, Gutierrez MG
Nature communications 2022 Nov 28;13(1):7338
Nature communications 2022 Nov 28;13(1):7338
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming.
Wang P, Jin JM, Liang XH, Yu MZ, Yang C, Huang F, Wu H, Zhang BB, Fei XY, Wang ZT, Xu R, Shi HL, Wu XJ
Acta pharmacologica Sinica 2022 Jun;43(6):1581-1593
Acta pharmacologica Sinica 2022 Jun;43(6):1581-1593
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited.
Li Z, Ji BW, Dixit PD, Tchourine K, Lien EC, Hosios AM, Abbott KL, Rutter JC, Westermark AM, Gorodetsky EF, Sullivan LB, Vander Heiden MG, Vitkup D
Nature metabolism 2022 Jun;4(6):711-723
Nature metabolism 2022 Jun;4(6):711-723
Beneficial effects of aloperine on inflammation and oxidative stress by suppressing necroptosis in lipopolysaccharide-induced acute lung injury mouse model.
Cui YR, Qu F, Zhong WJ, Yang HH, Zeng J, Huang JH, Liu J, Zhang MY, Zhou Y, Guan CX
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154074
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154074
A novel regulatory mechanism of geniposide for improving glucose homeostasis mediated by circulating RBP4.
Liu J, Song C, Nie C, Sun Y, Wang Y, Xue L, Fan M, Qian H, Wang L, Li Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153862
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153862
Legionella pneumophila modulates host energy metabolism by ADP-ribosylation of ADP/ATP translocases.
Fu J, Zhou M, Gritsenko MA, Nakayasu ES, Song L, Luo ZQ
eLife 2022 Jan 27;11
eLife 2022 Jan 27;11
Myricetin Restores Aβ-Induced Mitochondrial Impairments in N2a-SW Cells.
Yao X, Zhang J, Lu Y, Deng Y, Zhao R, Xiao S
ACS chemical neuroscience 2022 Feb 16;13(4):454-463
ACS chemical neuroscience 2022 Feb 16;13(4):454-463
Myoglobin-mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans.
Christen L, Broghammer H, Rapöhn I, Möhlis K, Strehlau C, Ribas-Latre A, Gebhardt C, Roth L, Krause K, Landgraf K, Körner A, Rohde-Zimmermann K, Hoffmann A, Klöting N, Ghosh A, Sun W, Dong H, Wolfrum C, Rassaf T, Hendgen-Cotta UB, Stumvoll M, Blüher M, Heiker JT, Weiner J
Clinical and translational medicine 2022 Dec;12(12):e1108
Clinical and translational medicine 2022 Dec;12(12):e1108
A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration.
Du J, Zheng L, Gao P, Yang H, Yang WJ, Guo F, Liang R, Feng M, Wang Z, Zhang Z, Bai L, Bu Y, Xing S, Zheng W, Wang X, Quan L, Hu X, Wu H, Chen Z, Chen L, Wei K, Zhang Z, Zhu X, Zhang X, Tu Q, Zhao SM, Lei X, Xiong JW
Cell stem cell 2022 Apr 7;29(4):545-558.e13
Cell stem cell 2022 Apr 7;29(4):545-558.e13
Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation.
Lin HC, Chen YJ, Wei YH, Lin HA, Chen CC, Liu TF, Hsieh YL, Huang KY, Lin KH, Wang HH, Chen LC
Frontiers in immunology 2021;12:630380
Frontiers in immunology 2021;12:630380
Growth hormone receptor disrupts glucose homeostasis via promoting and stabilizing retinol binding protein 4.
Liu J, Nie C, Xue L, Yan Y, Liu S, Sun J, Fan M, Qian H, Ying H, Wang L, Li Y
Theranostics 2021;11(17):8283-8300
Theranostics 2021;11(17):8283-8300
HIF-1 regulates energy metabolism of the Tibetan chicken brain during embryo development under hypoxia.
Tang Q, Xu Q, Ding C, Zhang H, Ling Y, Wu C, Fang M
American journal of physiology. Regulatory, integrative and comparative physiology 2021 May 1;320(5):R704-R713
American journal of physiology. Regulatory, integrative and comparative physiology 2021 May 1;320(5):R704-R713
Localization of myoglobin in mitochondria: implication in regulation of mitochondrial respiration in rat skeletal muscle.
Koma R, Shibaguchi T, Pérez López C, Oka T, Jue T, Takakura H, Masuda K
Physiological reports 2021 Mar;9(5):e14769
Physiological reports 2021 Mar;9(5):e14769
Resveratrol Is a Natural Inhibitor of Human Intestinal Mast Cell Activation and Phosphorylation of Mitochondrial ERK1/2 and STAT3.
Bilotta S, Paruchuru LB, Feilhauer K, Köninger J, Lorentz A
International journal of molecular sciences 2021 Jul 16;22(14)
International journal of molecular sciences 2021 Jul 16;22(14)
Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice.
Zhang XM, Deng H, Tong JD, Wang YZ, Ning XC, Yang XH, Zhou FQ, Jin HM
Journal of diabetes research 2020;2020:2817972
Journal of diabetes research 2020;2020:2817972
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Chen L, Peng J, Wang Y, Jiang H, Wang W, Dai J, Tang M, Wei Y, Kuang H, Xu G, Xu H, Zhou F
American journal of translational research 2020;12(2):428-446
American journal of translational research 2020;12(2):428-446
A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer.
Kodama M, Oshikawa K, Shimizu H, Yoshioka S, Takahashi M, Izumi Y, Bamba T, Tateishi C, Tomonaga T, Matsumoto M, Nakayama KI
Nature communications 2020 Mar 17;11(1):1320
Nature communications 2020 Mar 17;11(1):1320
Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction.
Liu Y, Sun L, Zheng L, Su M, Liu H, Wei Y, Li D, Wang Y, Dai C, Gong Y, Zhao C, Li Y
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jan;393(1):25-33
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jan;393(1):25-33
Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function.
Kľučková K, Thakker A, Vettore L, Escribano-Gonzalez C, Hindshaw RL, Tearle JLE, Goncalves J, Kaul B, Lavery GG, Favier J, Tennant DA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):303-315
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):303-315
The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer.
Zhuang Y, Ly RC, Frazier CV, Yu J, Qin S, Fan XY, Goetz MP, Boughey JC, Weinshilboum R, Wang L
Cancer & metabolism 2019;7:1
Cancer & metabolism 2019;7:1
ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer.
Zhao H, Wu S, Li H, Duan Q, Zhang Z, Shen Q, Wang C, Yin T
Molecular therapy oncolytics 2019 Sep 27;14:299-312
Molecular therapy oncolytics 2019 Sep 27;14:299-312
Low-dose PCB126 compromises circadian rhythms associated with disordered glucose and lipid metabolism in mice.
Shen X, Chen Y, Zhang J, Yan X, Liu W, Guo Y, Shan Q, Liu S
Environment international 2019 Jul;128:146-157
Environment international 2019 Jul;128:146-157
Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer.
Ma W, Zhao X, Wang K, Liu J, Huang G
Cancer biology & therapy 2018;19(9):835-846
Cancer biology & therapy 2018;19(9):835-846
Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins.
Horita H, Law A, Middleton K
Proteomes 2018 May 22;6(2)
Proteomes 2018 May 22;6(2)
(Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and Hepatosteatosis.
Ren L, Sun Y, Lu H, Ye D, Han L, Wang N, Daugherty A, Li F, Wang M, Su F, Tao W, Sun J, Zelcer N, Mullick AE, Danser AHJ, Jiang Y, He Y, Ruan X, Lu X
Circulation research 2018 Mar 2;122(5):730-741
Circulation research 2018 Mar 2;122(5):730-741
RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis.
Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J
Nature cell biology 2018 Feb;20(2):186-197
Nature cell biology 2018 Feb;20(2):186-197
Exogenous H(2)S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice.
Sun Y, Tian Z, Liu N, Zhang L, Gao Z, Sun X, Yu M, Wu J, Yang F, Zhao Y, Ren H, Chen H, Zhao D, Wang Y, Dong S, Xu C, Lu F, Zhang W
Journal of molecular medicine (Berlin, Germany) 2018 Apr;96(3-4):281-299
Journal of molecular medicine (Berlin, Germany) 2018 Apr;96(3-4):281-299
The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis.
Li G, Li M, Hu J, Lei R, Xiong H, Ji H, Yin H, Wei Q, Hu G
Oncogene 2017 Feb 16;36(7):989-998
Oncogene 2017 Feb 16;36(7):989-998
Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.
Li P, Zhang D, Shen L, Dong K, Wu M, Ou Z, Shi D
Scientific reports 2016 Mar 9;6:22831
Scientific reports 2016 Mar 9;6:22831
Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer.
Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, O'Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L, Chin CR, Stephanopolous G, Mott BT, Jacks T, Clish CB, Vander Heiden MG
Cell metabolism 2016 Mar 8;23(3):517-28
Cell metabolism 2016 Mar 8;23(3):517-28
ROS-mediated glucose metabolic reprogram induces insulin resistance in type 2 diabetes.
Dong K, Ni H, Wu M, Tang Z, Halim M, Shi D
Biochemical and biophysical research communications 2016 Aug 5;476(4):204-211
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Neuroscience 2013 Feb 12;231:345-52
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 18068-1-AP(PDHA1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using PDHA1 antibody 18068-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 18068-1-AP(PDHA1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 18068-1-AP(PDHA1 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue