Explore
Validate
Learn
Western blot
Immunocytochemistry
ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [24]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- ABIN409998 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) (pSer293) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- pSer293
- Vial size
- 0.05 mL
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references PPARγ activation regulates lipid droplet formation and lactate production in rat Sertoli cells.
Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis.
Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics.
Down-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts.
ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival.
Reactive oxygen species (ROS) production triggered by prostaglandin D2 (PGD2) regulates lactate dehydrogenase (LDH) expression/activity in TM4 Sertoli cells.
ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis.
Key glycolytic enzyme activities of skeletal muscle are decreased under fed and fasted states in mice with knocked down levels of Shc proteins.
Novel molecular mechanisms involved in hormonal regulation of lactate production in Sertoli cells.
Dichloroacetate affects proliferation but not survival of human colorectal cancer cells.
Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells.
Warburg-like Glycolysis and Lactate Shuttle in Mouse Decidua during Early Pregnancy.
The regulation of neuronal mitochondrial metabolism by calcium.
Silencing gastrin-releasing peptide receptor suppresses key regulators of aerobic glycolysis in neuroblastoma cells.
Activation of PPAR α and PPAR β/δ regulates Sertoli cell metabolism.
Shc depletion stimulates brown fat activity in vivo and in vitro.
Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase.
p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2.
Two protein kinase C isoforms, δ and ε, regulate energy homeostasis in mitochondria by transmitting opposing signals to the pyruvate dehydrogenase complex.
Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation.
The increase in cardiac pyruvate dehydrogenase kinase-4 after short-term dexamethasone is controlled by an Akt-p38-forkhead box other factor-1 signaling axis.
Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis.
Regulation of intermediary metabolism by the PKCdelta signalosome in mitochondria.
Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells.
Gorga A, Rindone GM, Regueira M, Pellizzari EH, Camberos MC, Cigorraga SB, Riera MF, Galardo MN, Meroni SB
Cell and tissue research 2017 Sep;369(3):611-624
Cell and tissue research 2017 Sep;369(3):611-624
Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis.
Jun JC, Devera R, Unnikrishnan D, Shin MK, Bevans-Fonti S, Yao Q, Rathore A, Younas H, Halberg N, Scherer PE, Polotsky VY
Journal of molecular medicine (Berlin, Germany) 2017 Mar;95(3):287-297
Journal of molecular medicine (Berlin, Germany) 2017 Mar;95(3):287-297
Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics.
Bhosale G, Sharpe JA, Koh A, Kouli A, Szabadkai G, Duchen MR
Biochimica et biophysica acta. Molecular cell research 2017 Jun;1864(6):1009-1017
Biochimica et biophysica acta. Molecular cell research 2017 Jun;1864(6):1009-1017
Down-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts.
Liu X, Zuo R, Bao Y, Qu X, Sun K, Ying H
Scientific reports 2017 Aug 16;7(1):8474
Scientific reports 2017 Aug 16;7(1):8474
ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival.
Zhong W, Yi Q, Xu B, Li S, Wang T, Liu F, Zhu B, Hoffmann PR, Ji G, Lei P, Li G, Li J, Li J, Olkkonen VM, Yan D
Nature communications 2016 Sep 1;7:12702
Nature communications 2016 Sep 1;7:12702
Reactive oxygen species (ROS) production triggered by prostaglandin D2 (PGD2) regulates lactate dehydrogenase (LDH) expression/activity in TM4 Sertoli cells.
Rossi SP, Windschüttl S, Matzkin ME, Rey-Ares V, Terradas C, Ponzio R, Puigdomenech E, Levalle O, Calandra RS, Mayerhofer A, Frungieri MB
Molecular and cellular endocrinology 2016 Oct 15;434:154-65
Molecular and cellular endocrinology 2016 Oct 15;434:154-65
ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis.
Lu H, Li X, Lu Y, Qiu S, Fan Z
Cancer letters 2016 Oct 10;381(1):23-30
Cancer letters 2016 Oct 10;381(1):23-30
Key glycolytic enzyme activities of skeletal muscle are decreased under fed and fasted states in mice with knocked down levels of Shc proteins.
Hagopian K, Tomilov AA, Kim K, Cortopassi GA, Ramsey JJ
PloS one 2015;10(4):e0124204
PloS one 2015;10(4):e0124204
Novel molecular mechanisms involved in hormonal regulation of lactate production in Sertoli cells.
Regueira M, Artagaveytia SL, Galardo MN, Pellizzari EH, Cigorraga SB, Meroni SB, Riera MF
Reproduction (Cambridge, England) 2015 Oct;150(4):311-21
Reproduction (Cambridge, England) 2015 Oct;150(4):311-21
Dichloroacetate affects proliferation but not survival of human colorectal cancer cells.
Delaney LM, Ho N, Morrison J, Farias NR, Mosser DD, Coomber BL
Apoptosis : an international journal on programmed cell death 2015 Jan;20(1):63-74
Apoptosis : an international journal on programmed cell death 2015 Jan;20(1):63-74
Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells.
Ho N, Coomber BL
Experimental cell research 2015 Feb 1;331(1):73-81
Experimental cell research 2015 Feb 1;331(1):73-81
Warburg-like Glycolysis and Lactate Shuttle in Mouse Decidua during Early Pregnancy.
Zuo RJ, Gu XW, Qi QR, Wang TS, Zhao XY, Liu JL, Yang ZM
The Journal of biological chemistry 2015 Aug 28;290(35):21280-91
The Journal of biological chemistry 2015 Aug 28;290(35):21280-91
The regulation of neuronal mitochondrial metabolism by calcium.
Llorente-Folch I, Rueda CB, Pardo B, Szabadkai G, Duchen MR, Satrustegui J
The Journal of physiology 2015 Aug 15;593(16):3447-62
The Journal of physiology 2015 Aug 15;593(16):3447-62
Silencing gastrin-releasing peptide receptor suppresses key regulators of aerobic glycolysis in neuroblastoma cells.
Rellinger EJ, Romain C, Choi S, Qiao J, Chung DH
Pediatric blood & cancer 2015 Apr;62(4):581-6
Pediatric blood & cancer 2015 Apr;62(4):581-6
Activation of PPAR α and PPAR β/δ regulates Sertoli cell metabolism.
Regueira M, Riera MF, Galardo MN, Pellizzari EH, Cigorraga SB, Meroni SB
Molecular and cellular endocrinology 2014 Jan 25;382(1):271-281
Molecular and cellular endocrinology 2014 Jan 25;382(1):271-281
Shc depletion stimulates brown fat activity in vivo and in vitro.
Tomilov A, Bettaieb A, Kim K, Sahdeo S, Tomilova N, Lam A, Hagopian K, Connell M, Fong J, Rowland D, Griffey S, Ramsey J, Haj F, Cortopassi G
Aging cell 2014 Dec;13(6):1049-58
Aging cell 2014 Dec;13(6):1049-58
Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase.
Wu CA, Chao Y, Shiah SG, Lin WW
Biochimica et biophysica acta 2013 May;1833(5):1147-56
Biochimica et biophysica acta 2013 May;1833(5):1147-56
p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2.
Contractor T, Harris CR
Cancer research 2012 Jan 15;72(2):560-7
Cancer research 2012 Jan 15;72(2):560-7
Two protein kinase C isoforms, δ and ε, regulate energy homeostasis in mitochondria by transmitting opposing signals to the pyruvate dehydrogenase complex.
Gong J, Hoyos B, Acin-Perez R, Vinogradov V, Shabrova E, Zhao F, Leitges M, Fischman D, Manfredi G, Hammerling U
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Aug;26(8):3537-49
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Aug;26(8):3537-49
Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation.
Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS
Genes & development 2011 Aug 15;25(16):1716-33
Genes & development 2011 Aug 15;25(16):1716-33
The increase in cardiac pyruvate dehydrogenase kinase-4 after short-term dexamethasone is controlled by an Akt-p38-forkhead box other factor-1 signaling axis.
Puthanveetil P, Wang Y, Wang F, Kim MS, Abrahani A, Rodrigues B
Endocrinology 2010 May;151(5):2306-18
Endocrinology 2010 May;151(5):2306-18
Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis.
Acin-Perez R, Hoyos B, Zhao F, Vinogradov V, Fischman DA, Harris RA, Leitges M, Wongsiriroj N, Blaner WS, Manfredi G, Hammerling U
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Feb;24(2):627-36
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Feb;24(2):627-36
Regulation of intermediary metabolism by the PKCdelta signalosome in mitochondria.
Acin-Perez R, Hoyos B, Gong J, Vinogradov V, Fischman DA, Leitges M, Borhan B, Starkov A, Manfredi G, Hammerling U
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Dec;24(12):5033-42
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Dec;24(12):5033-42
Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells.
McFate T, Mohyeldin A, Lu H, Thakar J, Henriques J, Halim ND, Wu H, Schell MJ, Tsang TM, Teahan O, Zhou S, Califano JA, Jeoung NH, Harris RA, Verma A
The Journal of biological chemistry 2008 Aug 15;283(33):22700-8
The Journal of biological chemistry 2008 Aug 15;283(33):22700-8
No comments: Submit comment
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
