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- References [12]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 66119-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- PDH E1 Alpha antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated PDH E1 Alpha antibody (Cat. #66119-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 2B3C10
- Vial size
- 20ul, 150ul
Submitted references Calcineurin inhibition deactivates pyruvate dehydrogenase and induces proximal tubule cell metabolic dysfunction, causing profibrotic phenotype.
Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice.
USP39 regulates pyruvate handling in non-small cell lung cancer.
The survivin-ran inhibitor LLP-3 decreases oxidative phosphorylation, glycolysis and growth of neuroblastoma cells.
MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion.
NOX4-Derived ROS Mediates TGF-β1-Induced Metabolic Reprogramming during Epithelial-Mesenchymal Transition through the PI3K/AKT/HIF-1α Pathway in Glioblastoma.
Sodium cantharidate induces Apoptosis in breast cancer cells by regulating energy metabolism via the protein phosphatase 5-p53 axis.
The mTOR-glycolytic pathway promotes T-cell immunobiology in oral lichen planus.
The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer.
A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.
PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy.
Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.
Oda Y, Nishi H, Hamano F, Yoshida T, Kita Y, Kopp JB, Nangaku M
bioRxiv : the preprint server for biology 2024 Nov 21;
bioRxiv : the preprint server for biology 2024 Nov 21;
Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice.
Li W, Li J, Li J, Wei C, Laviv T, Dong M, Lin J, Calubag M, Colgan LA, Jin K, Zhou B, Shen Y, Li H, Cui Y, Gao Z, Li T, Hu H, Yasuda R, Ma H
Science (New York, N.Y.) 2024 Dec 20;386(6728):eadp6547
Science (New York, N.Y.) 2024 Dec 20;386(6728):eadp6547
USP39 regulates pyruvate handling in non-small cell lung cancer.
Becirovic T, Zhang B, Vakifahmetoglu-Norberg H, Kaminskyy VO, Kochetkova E, Norberg E
Cell death discovery 2024 Dec 18;10(1):502
Cell death discovery 2024 Dec 18;10(1):502
The survivin-ran inhibitor LLP-3 decreases oxidative phosphorylation, glycolysis and growth of neuroblastoma cells.
Galiger C, Zohora FT, Dorneburg C, Tews D, Debatin KM, Beltinger C
BMC cancer 2023 Nov 25;23(1):1148
BMC cancer 2023 Nov 25;23(1):1148
MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion.
Zhang Y, Zhao M, Gao H, Yu G, Zhao Y, Yao F, Yang W
Nature metabolism 2022 Mar;4(3):374-388
Nature metabolism 2022 Mar;4(3):374-388
NOX4-Derived ROS Mediates TGF-β1-Induced Metabolic Reprogramming during Epithelial-Mesenchymal Transition through the PI3K/AKT/HIF-1α Pathway in Glioblastoma.
Su X, Yang Y, Guo C, Zhang R, Sun S, Wang Y, Qiao Q, Fu Y, Pang Q
Oxidative medicine and cellular longevity 2021;2021:5549047
Oxidative medicine and cellular longevity 2021;2021:5549047
Sodium cantharidate induces Apoptosis in breast cancer cells by regulating energy metabolism via the protein phosphatase 5-p53 axis.
Pang JL, Huang FH, Zhang YH, Wu Y, Ge XM, Li S, Li X
Toxicology and applied pharmacology 2021 Nov 1;430:115726
Toxicology and applied pharmacology 2021 Nov 1;430:115726
The mTOR-glycolytic pathway promotes T-cell immunobiology in oral lichen planus.
Wang F, Zhang J, Zhou G
Immunobiology 2020 May;225(3):151933
Immunobiology 2020 May;225(3):151933
The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer.
Zhuang Y, Ly RC, Frazier CV, Yu J, Qin S, Fan XY, Goetz MP, Boughey JC, Weinshilboum R, Wang L
Cancer & metabolism 2019;7:1
Cancer & metabolism 2019;7:1
A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.
Pryde KR, Taanman JW, Schapira AH
Cell reports 2016 Dec 6;17(10):2522-2531
Cell reports 2016 Dec 6;17(10):2522-2531
PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy.
Pryde KR, Smith HL, Chau KY, Schapira AH
The Journal of cell biology 2016 Apr 25;213(2):163-71
The Journal of cell biology 2016 Apr 25;213(2):163-71
Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.
Ma X, Li C, Sun L, Huang D, Li T, He X, Wu G, Yang Z, Zhong X, Song L, Gao P, Zhang H
Nature communications 2014 Oct 10;5:5212
Nature communications 2014 Oct 10;5:5212
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 66119-1-Ig(PDHA1 antibody) at dilution of 1:20000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PDHA1 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human PDHA1. This antibody recognizes human antigen. The PDHA1 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
